| The Battle of Olympus | EU | 1991 |
Brøderbund Software | Commercial |
| The Fantastic Adventures of Dizzy | EU | 1991 |
Camerica (NA) | Unlicensed |
| The Fantastic Adventures of Dizzy | US | 1991 |
Camerica (NA) | Unlicensed |
| The Fantastic Adventures of Dizzy | US | 1991 |
Camerica (NA) | Prototype |
| The King of Kings - The Early Years | US | 1991 |
Wisdom Tree | Unlicensed |
| The Ultimate Stuntman | AS | 1991 |
Camerica | Unlicensed |
| The Ultimate Stuntman | EU | 1991 |
Camerica | Unlicensed |
| Turbo Racing | EU | 1991 |
Data East | Commercial |
| Tecmo World Cup Soccer | EU | 1991-01 |
Tecmo | Commercial |
| The Hunt for Red October | AS | 1991-01 |
| Unlicensed |
| The Hunt for Red October | US | 1991-01 |
HiTech Software | Commercial |
| The Krion Conquest | US | 1991-01 |
Vic Tokai | Commercial |
| The Untouchables | US | 1991-01 |
Ocean Software | Commercial |
| The Adventures of Bayou Billy | EU | 1991-01-24 |
Konami Industry | Commercial |
| The Last Ninja | US | 1991-02 |
Beam Software | Commercial |
| The Simpsons - Bart vs. the Space Mutants | US | 1991-02 |
Acclaim Entertainment | Commercial |
| The Simpsons - Bart vs. the Space Mutants | US | 1991-02 |
Acclaim Entertainment | Prototype |
| The Simpsons - Bart vs. the World | US | 1991-02 |
Acclaim Entertainment | Commercial |
| Touchdown Fever | US | 1991-02 |
SNK | Commercial |
| Totally Rad | AS | 1991-03 |
| Unlicensed |
| Total Recall | EU | 1991-03-21 |
Acclaim Entertainment | Commercial |
| Takahashi Meijin no Bouken-jima II | JP | 1991-04 |
Hudson Soft | Commercial |
| Tenchi o Kurau II - Shokatsu Koumei Den | JP | 1991-04 |
Capcom | Commercial |
| Twin Eagle | JP | 1991-04-12 |
American Video Entertainment | Commercial |
| Taito Basketball | JP | 1991-04-26 |
Sammy | Commercial |
| Tetrastar - The Fighter | JP | 1991-05 |
Taito | Commercial |
| The Rocketeer | US | 1991-05 |
Bandai Namco | Commercial |
| Times of Lore | US | 1991-05 |
Toho | Commercial |
| The Adventures of Rad Gravity | EU | 1991-05-30 |
Activision | Commercial |
| Tombs & Treasure | US | 1991-06 |
Infocom | Commercial |
| Tsuppari Wars | JP | 1991-06-28 |
Sammy Studios | Commercial |
| The Little Mermaid | RU | 1991-07 |
| Unlicensed |
| The Little Mermaid | US | 1991-07 |
Capcom | Commercial |
| The Lone Ranger | US | 1991-08 |
Konami | Commercial |
| The Trolls in Crazyland | US | 1991-08 |
ASC | Prototype |
| Tokkyuu Shirei Solbrain | JP | 1991-10 |
Jaleco | Commercial |
| Trog! | EU | 1991-10 |
Acclaim Entertainment | Commercial |
| Trog! | US | 1991-10 |
Acclaim Entertainment | Commercial |
| Top Gun - The Second Mission | EU | 1991-10-24 |
Konami | Commercial |
| Time Zone | JP | 1991-10-25 |
Sigma Enterprises | Commercial |
| The Bard's Tale | US | 1991-11 |
FCI | Commercial |
| The Bard's Tale - Tales of the Unknown | US | 1991-11 |
FCI | Prototype |
| Totally Rad | US | 1991-11 |
Jaleco | Commercial |
| Teenage Mutant Hero Turtles II - The Arcade Game | EU | 1991-11-14 |
Konami | Commercial |
| Teenage Mutant Ninja Turtles II - The Arcade Game | AU | 1991-11-14 |
Konami | Commercial |
| TaleSpin | US | 1991-12 |
Capcom | Commercial |
| TaleSpin | WORLD | 1991-12 |
Capcom | Commercial |
| Tecmo Super Bowl | US | 1991-12 |
Tecmo | Commercial |
| Tecmo Super Bowl | US | 1991-12 |
Tecmo | Prototype |
| Teenage Mutant Ninja Turtles 2 - The Manhattan Project | JP | 1991-12 |
Konami | Commercial |
| The Flintstones - The Rescue of Dino & Hoppy | US | 1991-12 |
Taito | Commercial |
| The Simpsons - Bartman Meets Radioactive Man | US | 1991-12 |
Acclaim Entertainment | Commercial |
| The Simpsons - Bartman Meets Radioactive Man | US | 1991-12 |
Acclaim Entertainment | Prototype |
| Tiny Toon Adventures | US | 1991-12 |
Konami | Commercial |
| Toki | US | 1991-12 |
Taito | Commercial |
| Toki | US | 1991-12 |
Taito | Prototype |
| Tom & Jerry | AS | 1991-12 |
| Unlicensed |
| Tom & Jerry - The Ultimate Game of Cat and Mouse! | US | 1991-12 |
HiTech Software | Commercial |
| Toukyou Pachi-Slot Adventure | JP | 1991-12 |
Coconuts Japan | Commercial |
| Treasure Master | US | 1991-12 |
American Softworks | Commercial |
| Tsuru Pika Hagemaru - Mezase! Tsuru Seko no Akashi | JP | 1991-12 |
Jaleco | Commercial |
| The Simpsons - Bart vs. the Space Mutants | EU | 1991-12-12 |
Acclaim Entertainment | Commercial |
| Tecmo Super Bowl | JP | 1991-12-13 |
Tecmo | Commercial |
| Tetris 2 + Bombliss | JP | 1991-12-13 |
Bullet-Proof Software | Commercial |
| The Untouchables | JP | 1991-12-20 |
Ocean Software | Commercial |
| Tiny Toon Adventures | JP | 1991-12-20 |
Konami | Commercial |
| The Blue Marlin | JP | 1991-12-27 |
Hot-B | Commercial |
| The NewZealand Story | EU | 1991-12-27 |
Taito | Commercial |