| Tantei Jinguuji Saburou - Yokohamakou Renzoku Satsujin Jiken | JP | 1988-02 |
Data East | Commercial |
| Town & Country Surf Designs - Wood & Water Rage | US | 1988-02 |
LJN | Commercial |
| Tetsuwan Atom | JP | 1988-02-26 |
Konami | Commercial |
| Tanigawa Kouji no Shougi Shinan II | JP | 1988-03 |
Pony Canyon | Commercial |
| Tsuri Kichi Sanpei - Blue Marlin Hen | JP | 1988-03 |
Victor Interactive Software | Commercial |
| Takeda Shingen | JP | 1988-03-28 |
Hot-B | Commercial |
| The Tale - Elrond no Eiyuu | JP | 1988-07 |
Acclaim Entertainment | Prototype |
| Taiyou no Shinden | JP | 1988-08 |
Infocom | Commercial |
| Tatakae!! Rahmen Man - Sakuretsu Choujin 102 Gei | JP | 1988-08 |
Bandai | Commercial |
| The Money Game | JP | 1988-08-10 |
Sofel | Commercial |
| The Black Bass | JP | 1988-10 |
Hot-B | Commercial |
| The Black Bass II | JP | 1988-10-18 |
Hot-B | Commercial |
| Takeshi no Sengoku Fuuunji | JP | 1988-11 |
Taito | Commercial |
| Takeshi no Sengoku Fuuunji | JP | 1988-11 |
Taito | Prototype |
| Touhou Kenbun Roku | JP | 1988-11-10 |
Natsume | Commercial |
| Top Gun | EU | 1988-11-30 |
Konami | Commercial |
| Top Gun | RU | 1988-11-30 |
| Unlicensed |
| The Triathlon | JP | 1988-12 |
K. Amusement Leasing Co | Commercial |
| Totsuzen! Macchoman | JP | 1988-12 |
Sammy | Commercial |
| Totsuzen! Macchoman | JP | 1988-12 |
Sammy | Prototype |
| Top Rider | JP | 1988-12-17 |
Varie | Commercial |
| The Goonies II | EU | 1988-12-19 |
Konami | Commercial |
| Tetris | CN | 1988-12-22 |
| Unlicensed |
| Tetris | EU | 1988-12-22 |
Nintendo | Commercial |
| Tetris | JP | 1988-12-22 |
Nintendo | Commercial |
| Tetris | RU | 1988-12-22 |
| Unlicensed |
| Tetris | WORLD | 1988-12-22 |
Bullet-Proof Software | Unlicensed |