| S.C.A.T. - Special Cybernetic Attack Team | EU | 1992 |
Infogrames | Commercial |
| Sea of Dreamland | AS | 1992 |
Mega Soft | Unlicensed |
| Sea of Dreamland | EU | 1992 |
Mega Soft | Unlicensed |
| Secret Ties | US | 1992 |
Tokai Engineering | Prototype |
| Solitaire | US | 1992 |
American Video Entertainment | Unlicensed |
| Spiritual Warfare | US | 1992 |
Wisdom Tree | Prototype |
| Spiritual Warfare | US | 1992 |
Wisdom Tree | Unlicensed |
| Street Fighter II | TW | 1992 |
| Unlicensed |
| Strike Wolf | AS | 1992 |
Micro Genius | Unlicensed |
| Stunt Buggies | WORLD | 1992 |
Camerica | Unlicensed |
| Stunt Kids | US | 1992 |
Camerica | Unlicensed |
| Sunman | EU | 1992 |
Sunsoft | Prototype |
| Super Bros. 9 | AS | 1992 |
| Unlicensed |
| Super Fighter II' | AS | 1992 |
| Unlicensed |
| Super Gun | US | 1992 |
Caltron | Unlicensed |
| Super Mario World 9 | AS | 1992 |
| Unlicensed |
| Super Pang II | AS | 1992 |
Sachen | Unlicensed |
| Shougi Meikan '92 | JP | 1992-01 |
HectorSoft | Commercial |
| Shuiguan Pipe | AS | 1992-01 |
| Unlicensed |
| Solomon no Kagi 2 - Coolmintou Kyuushutsu Sakusen | JP | 1992-01 |
Tecmo | Commercial |
| Sword Master | AS | 1992-01 |
| Unlicensed |
| Sword Master | US | 1992-01 |
Athena | Commercial |
| Sword Master | US | 1992-01 |
Activision | Prototype |
| Sword Master | US | 1992-01 |
Activision | Demo |
| Skate Boy | AS | 1992-01-01 |
Gluk Video | Unlicensed |
| Skate Boy | EU | 1992-01-01 |
Gluk Video | Unlicensed |
| Super Spike V'Ball | EU | 1992-01-23 |
Nintendo | Commercial |
| Sesame Street - Countdown | US | 1992-02 |
HiTech Software | Commercial |
| Sesame Street - Countdown | US | 1992-02 |
HiTech Software | Prototype |
| Star Trek - 25th Anniversary | DE | 1992-02 |
Ultra Games | Commercial |
| Star Trek - 25th Anniversary | US | 1992-02 |
Ultra Games | Commercial |
| Super Spy Hunter | EU | 1992-02 |
Sunsoft | Commercial |
| Super Spy Hunter | US | 1992-02 |
Sunsoft | Commercial |
| Star Wars - The Empire Strikes Back | EU | 1992-03 |
JVC | Commercial |
| Star Wars - The Empire Strikes Back | US | 1992-03 |
JVC | Commercial |
| Star Wars - The Empire Strikes Back | US | 1992-03 |
JVC | Prototype |
| Super Momotarou Dentetsu | JP | 1992-03 |
Hudson Soft | Commercial |
| Soreike! Anpanman - Minna de Hiking Game! | JP | 1992-03-20 |
Bandai | Commercial |
| Snake's Revenge | EU | 1992-03-26 |
Ultra Games | Commercial |
| Side Pocket | EU | 1992-05-27 |
Data East | Commercial |
| Side Pocket | RU | 1992-05-27 |
| Unlicensed |
| Seiryaku Simulation - Inbou no Wakusei - Shancara | JP | 1992-06 |
IGS | Commercial |
| Sangokushi II - Haou no Tairiku | CN | 1992-06-10 |
| Unlicensed |
| Seirei Densetsu Lickle | JP | 1992-06-26 |
Taito | Commercial |
| Sanrio Cup - Pon Pon Volley | JP | 1992-07-17 |
Character Soft | Commercial |
| Summer Carnival '92 - Recca | JP | 1992-07-17 |
Naxat Soft | Commercial |
| Silva Saga | JP | 1992-07-24 |
SETA | Commercial |
| StarTropics | EU | 1992-08-20 |
Nintendo | Commercial |
| Super Contra 6 | AS | 1992-09 |
| Unlicensed |
| Super Mario USA | JP | 1992-09-14 |
Nintendo | Commercial |
| Spider-Man - Return of the Sinister Six | AS | 1992-10 |
| Unlicensed |
| Spider-Man - Return of the Sinister Six | US | 1992-10 |
LJN | Commercial |
| Spot | JP | 1992-10 |
Arcadia Systems | Commercial |
| Stanley - The Search for Dr. Livingston | US | 1992-10 |
Electro Brain | Commercial |
| Stanley - The Search for Dr. Livingston | US | 1992-10 |
Electro Brain | Prototype |
| Stanley - The Search for Dr. Livingston | WORLD | 1992-10 |
Electro Brain | Commercial |
| Shuffle Fight | JP | 1992-10-09 |
Banpresto | Commercial |
| SD Gundam Gaiden - Knight Gundam Monogatari 3 - Densetsu no Kishi Dan | JP | 1992-10-23 |
Bandai Namco | Commercial |
| Shatterhand | EU | 1992-11-19 |
Jaleco | Commercial |
| Spider-Man - Return of the Sinister Six | EU | 1992-11-29 |
LJN | Commercial |
| SD Gundam - Gachapon Senshi 5 - Battle of Universal Century | JP | 1992-12 |
Yutaka | Commercial |
| Shougi Meikan '93 | JP | 1992-12 |
HectorSoft | Commercial |
| Swamp Thing | EU | 1992-12 |
THQ | Commercial |
| Swamp Thing | US | 1992-12 |
THQ | Commercial |