| Scarabeus | US | 1991 |
Matchbox International Ltd | Prototype |
| Secret Scout in the Temple of Demise | US | 1991 |
Color Dreams | Prototype |
| Secret Scout in the Temple of Demise | US | 1991 |
Color Dreams | Unlicensed |
| Sheng Huo Lie Zhuan | CN | 1991 |
Computer & Entertainment | Unlicensed |
| Sheng Huo Lie Zhuan | TW | 1991 |
Computer & Entertainment | Unlicensed |
| Shockwave | US | 1991 |
American Game Cartridges | Unlicensed |
| SimCity | US | 1991 |
Nintendo | Prototype |
| Soap Panic | JP | 1991 |
Panesian | Unlicensed |
| Stakk'm | US | 1991 |
American Video Entertainment | Prototype |
| Strategist | AS | 1991 |
Sachen | Unlicensed |
| Strategist | TW | 1991 |
Sachen | Unlicensed |
| Street Gangs | EU | 1991 |
Infogrames | Commercial |
| Super Adventure Quests | EU | 1991 |
Codemasters | Unlicensed |
| Super Mario Bros. 4 | AS | 1991 |
| Unlicensed |
| Super Mario IV | AS | 1991 |
| Unlicensed |
| Super Pang | AS | 1991 |
Sachen | Unlicensed |
| Super Sports Challenge - Quattro Sports | EU | 1991 |
Camerica | Unlicensed |
| Shentan Kenan | CN | 1991-02 |
King Records | Unlicensed |
| Super Cars | US | 1991-02 |
Magnetic Fields | Commercial |
| Squashed | US | 1991-03 |
Jaleco | Prototype |
| Super Chinese 3 | JP | 1991-03-01 |
Culture Brain | Commercial |
| Shadow Brain | JP | 1991-03-21 |
Pony Canyon | Commercial |
| Snake Rattle n Roll | EU | 1991-03-27 |
Nintendo | Commercial |
| Shikinjou | JP | 1991-04 |
Toei Animation | Commercial |
| Shadowgate | DE | 1991-05-30 |
Kemco | Commercial |
| Shadowgate | EU | 1991-05-30 |
Kemco | Commercial |
| Shadowgate | FR | 1991-05-30 |
Kemco | Commercial |
| Shadowgate | SE | 1991-05-30 |
Kemco | Commercial |
| S.C.A.T. - Special Cybernetic Attack Team | US | 1991-06 |
Infogrames | Commercial |
| S.C.A.T. - Special Cybernetic Attack Team | US | 1991-06 |
Infogrames | Prototype |
| Sugoro Quest - Dice no Senshitachi | AS | 1991-06 |
| Unlicensed |
| Sugoro Quest - Dice no Senshitachi | JP | 1991-06 |
Technōs Japan | Commercial |
| Shin 4 Nin Uchi Mahjong - Yakuman Tengoku | JP | 1991-06-28 |
Nintendo | Commercial |
| Super Little Mamaid 2 | AS | 1991-07 |
| Unlicensed |
| Super Ninja Cat | AS | 1991-07 |
| Unlicensed |
| Shadow of the Ninja | EU | 1991-07-25 |
Taito | Commercial |
| SD Keiji - Blader | JP | 1991-08-02 |
Taito | Commercial |
| Super Sprint | JP | 1991-08-03 |
Atari | Commercial |
| Super Mario Bros. 3 | EU | 1991-08-29 |
Nintendo | Commercial |
| Smash T.V | EU | 1991-09 |
Acclaim Entertainment | Commercial |
| Smash T.V | US | 1991-09 |
Acclaim Entertainment | Commercial |
| Super Jeopardy! | US | 1991-09 |
GameTek | Commercial |
| Solar Jetman - Hunt for the Golden Warpship | EU | 1991-09-26 |
Nintendo | Commercial |
| Solstice - The Quest for the Staff of Demnos | EU | 1991-09-26 |
Nintendo | Commercial |
| Spartan X 2 | JP | 1991-09-27 |
Irem | Commercial |
| SD Gundam Gaiden - Knight Gundam Monogatari 2 - Hikari no Knight | JP | 1991-10 |
Bandai | Commercial |
| Square Deal | JP | 1991-10 |
HectorSoft | Demo |
| Ski or Die | EU | 1991-10-24 |
Ultra Games | Commercial |
| Sesame Street - ABC & 123 | US | 1991-11 |
HiTech Software | Commercial |
| Shounen Ashibe - Nepal Daibouken no Maki | JP | 1991-11 |
Takara | Commercial |
| Snow Brothers | EU | 1991-11 |
Capcom | Commercial |
| Snow Brothers | US | 1991-11 |
Capcom | Commercial |
| Space Shuttle Project | US | 1991-11 |
Absolute Entertainment | Commercial |
| Star Wars | JP | 1991-11 |
JVC | Commercial |
| Stealth ATF | EU | 1991-11-14 |
Activision | Commercial |
| Swords and Serpents | EU | 1991-11-28 |
Interplay | Commercial |
| Swords and Serpents | FR | 1991-11-28 |
Interplay | Commercial |
| SD Gundam - Gachapon Senshi 4 - NewType Story | JP | 1991-12 |
Yutaka | Commercial |
| Shatterhand | US | 1991-12 |
Jaleco | Commercial |
| Shatterhand | US | 1991-12 |
Jaleco | Prototype |
| Snow Bros | JP | 1991-12 |
Capcom | Commercial |
| Star Wars | US | 1991-12 |
JVC | Commercial |
| Star Wars | US | 1991-12 |
JVC | Prototype |
| Super Rescue RoboCop 3 | AS | 1991-12 |
| Unlicensed |