| R.B.I. Baseball 3 | US | 1991 |
Atari | Unlicensed |
| Rad Racket - Deluxe Tennis II | TW | 1991 |
American Video Entertainment | Unlicensed |
| Rad Racket - Deluxe Tennis II | US | 1991 |
American Video Entertainment | Prototype |
| Rainbow Islands - Bubble Bobble 2 | EU | 1991 |
Ocean Software | Commercial |
| Rescue - The Embassy Mission | EU | 1991-03-27 |
Infogrames | Commercial |
| RoboCop 2 | US | 1991-04 |
Ocean Software | Commercial |
| RoboCop 2 | US | 1991-04 |
Data East | Prototype |
| RoboCop 2 | EU | 1991-04-02 |
Ocean Software | Commercial |
| RoboCop 2 | JP | 1991-04-02 |
Ocean Software | Commercial |
| RoboCop | EU | 1991-04-25 |
Data East | Commercial |
| Rainbow Islands | US | 1991-06 |
Taito | Commercial |
| Rockman 4 - Aratanaru Yabou!! | JP | 1991-06 |
Capcom | Commercial |
| Robocco Wars | JP | 1991-08-02 |
IGS | Commercial |
| Royal Blood | JP | 1991-08-29 |
Koei | Commercial |
| Rockin' Kats | US | 1991-09 |
Atlus | Commercial |
| Rockin' Kats | US | 1991-09 |
Atlus | Prototype |
| Romance of the Three Kingdoms II | US | 1991-09 |
Koei | Commercial |
| Roger Clemens' MVP Baseball | US | 1991-10 |
Sculptured Software | Commercial |
| Rollergames | EU | 1991-10-24 |
Konami | Commercial |
| Radia Senki - Reimei Hen | JP | 1991-11 |
Tecmo | Commercial |
| Robin Hood - Prince of Thieves | US | 1991-11 |
Virgin | Commercial |
| Robin Hood - Prince of Thieves | US | 1991-11 |
Virgin | Prototype |
| Rampart | JP | 1991-11-29 |
Jaleco | Commercial |
| Rampart | JP | 1991-11-29 |
Jaleco | Demo |