| Mario 16 | AS | 1993 |
| Unlicensed |
| Master Fighter VI' | AS | 1993 |
| Unlicensed |
| Master Fighter VI' | TW | 1993 |
| Unlicensed |
| Master Shooter | TW | 1993 |
NTDEC | Unlicensed |
| Metal Force | KR | 1993 |
Daou Infosys | Unlicensed |
| Mick & Mack as the Global Gladiators | US | 1993 |
Virgin Games | Prototype |
| Mega Man 4 | EU | 1993-01-21 |
Capcom | Commercial |
| Mickey's Safari in Letterland | US | 1993-03 |
Hi Tech Expressions | Commercial |
| Mezase! Top Pro - Green ni Kakeru Yume | JP | 1993-03-05 |
Jaleco | Commercial |
| Moero TwinBee - Cinnamon Hakase o Sukue! | AS | 1993-03-26 |
| Unlicensed |
| Moero TwinBee - Cinnamon Hakase o Sukue! | JP | 1993-03-26 |
Konami | Commercial |
| McDonaldland | EU | 1993-05 |
Virgin Interactive | Commercial |
| McDonaldland | FR | 1993-05 |
Virgin Interactive | Commercial |
| Mr. Gimmick | EU | 1993-05-19 |
Sunsoft | Commercial |
| Mr. Gimmick | US | 1993-05-19 |
Sunsoft | Prototype |
| Mighty Final Fight | JP | 1993-06-11 |
Capcom | Commercial |
| Mario is Missing! | EU | 1993-07 |
The Software Toolworks | Commercial |
| Mario is Missing! | US | 1993-07 |
The Software Toolworks | Commercial |
| Mighty Final Fight | US | 1993-07 |
Capcom | Commercial |
| Ms. Pac-Man | US | 1993-11 |
Namco | Commercial |
| Ms. Pac-Man | US | 1993-11 |
Namco | Unlicensed |
| Mega Man 6 | WORLD | 1993-11-05 |
Capcom | Commercial |
| Mega Man 5 | EU | 1993-11-18 |
Capcom | Commercial |
| Mali & Lugi Fighting 2 | AS | 1993-12 |
| Unlicensed |
| Momotarou Densetsu Gaiden | JP | 1993-12 |
Hudson Soft | Commercial |
| Mighty Final Fight | EU | 1993-12-02 |
Capcom | Commercial |