| Final Fantasy II | US | 1991 |
Squaresoft | Prototype |
| Firehawk | EU | 1991 |
Codemasters | Unlicensed |
| Firehawk | US | 1991 |
Codemasters | Unlicensed |
| Futebol | BR | 1991 |
Milmar Indústria e Comércio Ltda | Unlicensed |
| Fighting Hero | TW | 1991-01 |
NTDEC | Unlicensed |
| Fox's Peter Pan & the Pirates - The Revenge of Captain Hook | US | 1991-01 |
THQ | Commercial |
| Fun House | US | 1991-01 |
HiTech Software | Commercial |
| Famicom Shougi - Ryuuousen | JP | 1991-02 |
I'Max | Commercial |
| Famicom Shougi - Ryuuousen | JP | 1991-02 |
I'Max | Prototype |
| Flying Warriors | US | 1991-02 |
Culture Brain | Commercial |
| Flying Warriors | US | 1991-02 |
Culture Brain | Prototype |
| Fushigi no Umi no Nadia | JP | 1991-03-15 |
Toho | Commercial |
| Family Block | JP | 1991-04-12 |
Romstar | Commercial |
| Family Feud | US | 1991-05 |
GameTek | Commercial |
| Flight of the Intruder | US | 1991-05 |
Mindscape | Commercial |
| Flight of the Intruder | US | 1991-05 |
Mindscape | Prototype |
| Fuzzical Fighter | JP | 1991-05-17 |
Sigma Enterprises | Commercial |
| Faria - A World of Mystery & Danger! | US | 1991-06 |
Nexoft | Commercial |
| Frankenstein - The Monster Returns | US | 1991-07 |
Bandai | Commercial |
| Frankenstein - The Monster Returns | US | 1991-07 |
Bandai | Prototype |
| Family Circuit '91 | JP | 1991-07-19 |
Namco | Commercial |
| Famicom Igo Nyuumon | JP | 1991-11-29 |
I'Max | Commercial |
| Famicom Jump II - Saikyou no 7 Nin | JP | 1991-12 |
Bandai | Commercial |
| Famista '92 | JP | 1991-12-20 |
Namco | Commercial |