| D.J. Boy | AS | 1991 |
| Unlicensed |
| Death Race | US | 1991 |
American Game Cartridges | Unlicensed |
| Digger T. Rock - The Legend of the Lost City | AS | 1991 |
| Unlicensed |
| Digger T. Rock - The Legend of the Lost City | EU | 1991 |
Milton Bradley | Commercial |
| Digger T. Rock - The Legend of the Lost City | US | 1991 |
Milton Bradley | Prototype |
| Dino Hockey | US | 1991 |
Sunsoft | Prototype |
| Drac's Night Out | US | 1991 |
Parker Brothers | Prototype |
| Dream Fighter | AS | 1991 |
Caltron | Unlicensed |
| Double Dragon III - The Rosetta Stone | US | 1991-02 |
Technōs Japan | Prototype |
| Double Dragon III - The Sacred Stones | US | 1991-02 |
Acclaim Entertainment | Commercial |
| Dark Lord | JP | 1991-02-08 |
Data East | Commercial |
| Double Dragon III - The Rosetta Stone | JP | 1991-02-22 |
Acclaim Entertainment | Commercial |
| Daikoukai Jidai | JP | 1991-03 |
Koei | Commercial |
| Days of Thunder | EU | 1991-04-25 |
Mindscape | Commercial |
| Du Shen - Numen Wager | CN | 1991-06 |
| Unlicensed |
| Du Shen - Zhi Shai Zhanshi | CN | 1991-06 |
| Unlicensed |
| Du Wang - Moses Wager | CN | 1991-06 |
| Unlicensed |
| Dynablaster | EU | 1991-06 |
Hudson Soft | Commercial |
| Dr. Mario | EU | 1991-06-27 |
Nintendo | Commercial |
| Downtown Special - Kunio-kun no Jidaigeki Da yo Zenin Shuugou! | JP | 1991-07 |
Technōs Japan | Commercial |
| Die Hard | JP | 1991-07-19 |
Activision | Commercial |
| Defender of the Crown | EU | 1991-07-25 |
Palcom | Commercial |
| Defender of the Crown | FR | 1991-07-25 |
Palcom | Commercial |
| Downtown Special - Kunio-kun no Jidaigeki Da yo Zenin Shuugou! | JP | 1991-07-26 |
| Unlicensed |
| Doki! Doki! Yuuenchi - Crazy Land Daisakusen | AS | 1991-08 |
| Unlicensed |
| Doki! Doki! Yuuenchi - Crazy Land Daisakusen | JP | 1991-08 |
Vap | Commercial |
| De-Block | JP | 1991-08-09 |
Athena | Commercial |
| Dragon Wars | JP | 1991-08-09 |
Interplay | Commercial |
| Dragon Wars | US | 1991-08-09 |
Interplay | Prototype |
| Dragon's Lair | JP | 1991-09-20 |
Elite Systems | Commercial |
| Double Dragon II - The Revenge | EU | 1991-09-26 |
Acclaim Entertainment | Commercial |
| Darkman | US | 1991-10 |
Ocean Software | Commercial |
| Dragon Ball Z II - Gekishin Freeza!! | JP | 1991-10 |
Bandai | Commercial |
| Daiku no Gen-san | JP | 1991-11-15 |
Irem | Commercial |
| Dick Tracy | US | 1991-12 |
Bandai America | Commercial |
| Dynamite Batman | JP | 1991-12 |
Sunsoft | Commercial |
| Dai-2-ji Super Robot Taisen | JP | 1991-12-29 |
Banpresto | Commercial |