| Dancing Blocks | TW | 1990 |
Sachen | Unlicensed |
| Death Race | US | 1990 |
AGCI | Prototype |
| Deathbots | US | 1990 |
American Video Entertainment | Unlicensed |
| Die Bian - Incantation | TW | 1990 |
Bunch Games | Unlicensed |
| Double Strike - Aerial Attack Force | US | 1990 |
American Video Entertainment | Unlicensed |
| Dudes with Attitude | US | 1990 |
American Video Entertainment | Unlicensed |
| David Crane's A Boy and His Blob - Trouble on Blobolonia | EU | 1990-01 |
Nintendo | Commercial |
| David Crane's A Boy and His Blob - Trouble on Blobolonia | US | 1990-01 |
Nintendo | Commercial |
| Demon Sword | US | 1990-01 |
Taito | Commercial |
| Double Dragon II - The Revenge | US | 1990-01 |
Acclaim Entertainment | Commercial |
| Dash Galaxy in the Alien Asylum | US | 1990-02 |
Data East | Commercial |
| Dead Fox | JP | 1990-02 |
Capcom | Commercial |
| Dead Fox | JP | 1990-02 |
Capcom | Demo |
| Destination Earthstar | US | 1990-02 |
Acclaim Entertainment | Commercial |
| Dragon Quest IV - Michibikareshi Monotachi | JP | 1990-02-11 |
Enix | Commercial |
| Dragon Unit | JP | 1990-02-27 |
SETA | Commercial |
| Don Doko Don | JP | 1990-03-09 |
Taito | Commercial |
| Deep Dungeon IV - Kuro no Youjutsushi | JP | 1990-04 |
Asmik | Commercial |
| Double Dare | US | 1990-04 |
GameTek | Commercial |
| Dynowarz - The Destruction of Spondylus | US | 1990-04 |
Bandai | Commercial |
| Digital Devil Story - Megami Tensei II | JP | 1990-04-06 |
Namco | Commercial |
| Dragon Spirit - The New Legend | US | 1990-06 |
Bandai | Commercial |
| Dash Yarou | JP | 1990-06-15 |
Romstar | Commercial |
| Dungeon Magic - Sword of the Elements | US | 1990-07 |
Taito | Commercial |
| Dusty Diamond's All-Star Softball | US | 1990-07 |
Brøderbund Software | Commercial |
| Dragon Ball - Le Secret du Dragon | FR | 1990-07-18 |
Bandai | Commercial |
| Dr. Mario | AS | 1990-07-27 |
| Unlicensed |
| Dr. Mario | JP | 1990-07-27 |
Nintendo | Commercial |
| Dragon Fighter | AS | 1990-08-10 |
| Unlicensed |
| Dragon Fighter | JP | 1990-08-10 |
Sofel | Commercial |
| Dungeon Kid | JP | 1990-08-31 |
Quest | Commercial |
| Destiny of an Emperor | US | 1990-09 |
Capcom | Commercial |
| Doraemon - Giga Zombie no Gyakushuu | JP | 1990-09 |
Epoch | Commercial |
| Dragon Warrior II | US | 1990-09 |
Enix | Commercial |
| Dragon Warrior II | US | 1990-09 |
Enix | Prototype |
| Days of Thunder | US | 1990-10 |
Mindscape | Commercial |
| Days of Thunder | US | 1990-10 |
Mindscape | Prototype |
| Downtown - Nekketsu Koushinkyoku - Soreyuke Daiundoukai | JP | 1990-10 |
Technōs Japan | Commercial |
| Dr. Mario | US | 1990-10 |
Nintendo | Commercial |
| Dr. Mario | US | 1990-10 |
Nintendo | Prototype |
| Dragon Ball Z - Kyoushuu! Saiya Jin | JP | 1990-10 |
Bandai | Commercial |
| Daikaijuu Deburas | JP | 1990-12 |
Data East | Commercial |
| Deja Vu | US | 1990-12 |
Kemco | Commercial |
| Deja Vu | US | 1990-12 |
Kemco | Prototype |
| Digger T. Rock - The Legend of the Lost City | US | 1990-12 |
Milton Bradley | Commercial |
| Dirty Harry | US | 1990-12 |
Mindscape | Commercial |
| Dragon's Lair | US | 1990-12 |
Elite Systems | Commercial |
| DuckTales | EU | 1990-12-14 |
Capcom | Commercial |