| Castle of Deceit | US | 1990 |
Bunch Games | Unlicensed |
| Challenge of the Dragon | AS | 1990 |
Color Dreams | Unlicensed |
| Challenge of the Dragon | US | 1990 |
Color Dreams | Unlicensed |
| Chiller | AU | 1990 |
American Game Cartridges | Unlicensed |
| Chiller | US | 1990 |
AGCI | Prototype |
| Chiller | US | 1990 |
American Game Cartridges | Unlicensed |
| Chuck Yeager's Fighter Combat | US | 1990 |
Electronic Arts | Prototype |
| Corvette ZR-1 Challenge | EU | 1990 |
Milton Bradley | Commercial |
| Chris Evert & Ivan Lendl in Top Players' Tennis | US | 1990-01 |
Nintendo | Commercial |
| Clash at Demonhead | US | 1990-01 |
Vic Tokai | Commercial |
| Cadillac | JP | 1990-02-02 |
HectorSoft | Commercial |
| Cadillac | JP | 1990-02-02 |
HectorSoft | Demo |
| Code Name - Viper | US | 1990-03 |
Capcom | Commercial |
| Conflict | US | 1990-03 |
Vic Tokai | Commercial |
| Castlevania II - Simon's Quest | EU | 1990-04-27 |
Konami | Commercial |
| Castle Quest | JP | 1990-05-18 |
Hudson Soft | Commercial |
| Cabal | US | 1990-06 |
Milton Bradley | Commercial |
| Captain Skyhawk | US | 1990-06 |
Nintendo | Commercial |
| Castle of Dragon | US | 1990-06 |
SETA | Commercial |
| Chip & Dales | AS | 1990-06 |
| Unlicensed |
| Chip 'n Dale - Rescue Rangers | US | 1990-06 |
Capcom | Commercial |
| Chip 'n Dale - Rescue Rangers | WORLD | 1990-06 |
Capcom | Commercial |
| Chip to Dale no Daisakusen | JP | 1990-06 |
Capcom | Commercial |
| Captain Tsubasa II - Super Striker | JP | 1990-07 |
Tecmo | Commercial |
| Circus Caper | US | 1990-07 |
Toho | Commercial |
| Crystalis | EU | 1990-07 |
SNK | Commercial |
| Crystalis | US | 1990-07 |
SNK | Commercial |
| Crystalis | US | 1990-07 |
SNK | Prototype |
| Classic Concentration | US | 1990-09 |
GameTek | Commercial |
| Castlevania III - Dracula's Curse | US | 1990-09-19 |
Konami | Commercial |
| Caveman Games | US | 1990-10 |
Data East | Commercial |
| Conquest of the Crystal Palace | US | 1990-11 |
Asmik | Commercial |
| CrossFire | US | 1990-11 |
Kyugo Boueki | Prototype |
| CrossFire | JP | 1990-11-02 |
Kyugo Boueki | Commercial |
| Chiyonofuji no Ooichou | JP | 1990-12 |
FACE | Commercial |
| Contra | RU | 1990-12-28 |
| Unlicensed |