| Street Racer | EU | 1995-04 |
Ubisoft | Commercial |
| Street Racer | EU | 1995-04 |
Ubisoft | Demo |
| Street Smart | JP | 1991-07-19 |
Treco | Commercial |
| Street Smart | JP | 1991-07-19 |
Treco | Prototype |
| Street Smart | US | 1991-06 |
Treco | Commercial |
| Street Smart | US | 1991-06 |
Treco | Prototype |
| Streets of Rage | WORLD | 1991-08 |
Sega of America | Commercial |
| Streets of Rage 2 | US | 1992-12 |
Sega of America | Commercial |
| Streets of Rage 3 | AS | 1994-03 |
Sega of America | Commercial |
| Streets of Rage 3 | EU | 1994-06 |
Sega of America | Commercial |
| Streets of Rage 3 | EU | 1994-06 |
Sega of America | Prototype |
| Streets of Rage 3 | US | 1994-03 |
Sega of America | Commercial |
| Streets of Rage 3 | US | 1994-03 |
Sega of America | Prototype |
| Streets of Rage II | EU | 1993-01 |
Sega of America | Commercial |
| Streets of Rage II | JP | 1993-01 |
Sega of America | Commercial |
| Strider | EU | 1990-09 |
Capcom | Commercial |
| Strider | US | 1990-12 |
Capcom | Commercial |
| Strider Hiryuu | JP | 1990-09-29 |
Capcom | Commercial |
| Strider Hiryuu | KR | 1990-09-29 |
Capcom | Commercial |
| Strider II | EU | 1993-03 |
Capcom | Commercial |
| Striker | EU | 1995-06 |
Sega Enterprises | Prototype |
| Striker | EU | 1995-06 |
Sega Enterprises | Commercial |
| Sub-Terrania | AS | 1994-04 |
Scavenger | Commercial |
| Sub-Terrania | AS | 1994-04 |
Scavenger | Prototype |
| Sub-Terrania | EU | 1994-05 |
Scavenger | Commercial |
| Sub-Terrania | US | 1994-03 |
Scavenger | Commercial |
| Sub-Terrania | US | 1994-03 |
Scavenger | Prototype |
| Submarine Attack | WORLD | 2025-08 |
Camden Town Games | Unlicensed |
| Submarine Canyon Bomber vs Marine Aliens | WORLD | 2017 |
Hideki Konishi | Unlicensed |
| Sudoku | WORLD | |
| Unlicensed |
| Sukiya | WORLD | 2021-04 |
Z-team | Prototype |
| Summer Challenge | EU | 1993-05 |
Accolade | Unlicensed |
| Summer Challenge | US | 1993-05 |
Accolade | Unlicensed |
| Summer Challenge | WORLD | 1993-05 |
Accolade | Unlicensed |
| Sumo Slam | WORLD | 2013 |
Segaman Production | Unlicensed |
| Sunset Riders | EU | 1993-04 |
Konami | Commercial |
| Sunset Riders | US | 1992-12 |
Konami | Commercial |
| Super Airwolf | JP | 1991-03-29 |
Kyugo Boueki | Commercial |
| Super Baseball 2020 | EU | 1993-09 |
Electronic Arts | Commercial |
| Super Baseball 2020 | US | 1993-09 |
Electronic Arts | Commercial |
| Super Battleship - The Classic Naval Combat Game | US | 1993-02 |
Mindscape | Commercial |
| Super Bubble Bobble | TW | |
Gamtec | Unlicensed |
| Super Byoon | WORLD | |
| Unlicensed |
| Super Daisenryaku | JP | 1989-04-29 |
Sega Enterprises | Commercial |
| Super Donkey Kong 99 | TW | 1999 |
Gamtec | Unlicensed |
| Super Fantasy Zone | EU | 1993 |
Sega | Commercial |
| Super Fantasy Zone | JP | 1992-01-14 |
Sega | Commercial |
| Super Fantasy Zone | US | 1993 |
Sega | Commercial |
| Super H.Q | JP | 1992-10-23 |
Taito | Commercial |
| Super Hang-On | EU | 1989-10-06 |
Sega Enterprises | Commercial |
| Super Hang-On | JP | 1989-10-06 |
Sega Enterprises | Commercial |
| Super Hang-On | JP | 1989-10-06 |
Sega Enterprises | Prototype |
| Super Hang-On | US | 1989-11 |
Sega Enterprises | Commercial |
| Super Hang-On | US | 1989-11 |
Sega Enterprises | Prototype |
| Super Hard Bouncer | WORLD | 2025-01 |
Libra Bits | Unlicensed |
| Super High Impact | US | 1992-09 |
Arena Entertainment | Commercial |
| Super Hydlide | EU | 1991 |
Asmik | Commercial |
| Super Hydlide | JP | 1989-10-06 |
Asmik | Commercial |
| Super Hydlide | US | 1990-03 |
Asmik | Commercial |
| Super Hydlide | US | 1990-03 |
Asmik | Prototype |
| Super Kick Off | EU | 1993-04 |
Tiertex | Commercial |
| Super King Kong 99 | TW | 1999 |
Gamtec | Unlicensed |
| Super League | EU | 1990 |
Sega of America | Commercial |
| Super League | JP | 1989-04-22 |
Sega of America | Commercial |
| Super Locomotive | WORLD | 2022-10 |
Sega | Commercial |
| Super Magican - Ling Huan Daoshi | TW | 1994 |
Gamtec | Unlicensed |
| Super Mario 2 | TW | 1998 |
Gamtec | Unlicensed |
| Super Mario Bros | TW | 1996 |
Gamtec | Unlicensed |
| Super Mario World | TW | 1996 |
Jazz Dark | Unlicensed |
| Super Mario World 64 | TW | 1997 |
Gamtec | Unlicensed |
| Super Maximum Overkill | WORLD | 2022-03 |
SpacePantsGames | Unlicensed |
| Super Monaco GP | JP | 1990-08-09 |
Sega Enterprises | Commercial |
| Super Monaco GP | US | 1990-09 |
Sega Enterprises | Commercial |
| Super Monaco GP | WORLD | 1990-08-09 |
Sega Enterprises | Commercial |
| Super Off Road | EU | 1992-04-15 |
Software Creations | Unlicensed |
| Super Off Road | US | 1992-04 |
Software Creations | Unlicensed |
| Super Real Basketball | EU | 1991-03 |
Sega of America | Commercial |
| Super Real Basketball | JP | 1990-03-02 |
Sega of America | Commercial |
| Super Real Basketball | KR | 1990-03 |
Sega of America | Commercial |
| Super Skidmarks | EU | 1995-11 |
Codemasters | Prototype |
| Super Skidmarks | EU | 1995-11 |
Codemasters | Commercial |
| Super Smash T.V | EU | 1992-08 |
Probe Entertainment | Commercial |
| Super Smash T.V | US | 1992-08 |
Probe Entertainment | Commercial |
| Super Star Wars - Holiday Special | WORLD | 2024-12 |
Master Linkuei | Unlicensed |
| Super Street Fighter II | EU | 1994-08-19 |
Capcom | Commercial |
| Super Street Fighter II | US | 1994-07-07 |
Capcom | Commercial |
| Super Street Fighter II - The New Challengers | JP | 1994-06 |
Capcom | Commercial |
| Super Street Fighter II - The New Challengers | US | 1994-06 |
Capcom | Commercial |
| Super Tank War | TW | 1992 |
Gamtec | Unlicensed |
| Super Thunder Blade | JP | 1988-10-29 |
Sega of America | Commercial |
| Super Thunder Blade | WORLD | 1988-10-29 |
Sega of America | Commercial |
| Super Volley Ball | JP | 1991-02 |
Video System | Commercial |
| Super Volley Ball | US | 1991-02 |
| Unlicensed |
| Super Volleyball | US | 1991-02 |
Video System | Commercial |
| Superman | US | 1992-12 |
Sunsoft | Commercial |
| Superman | US | 1992-12 |
Sunsoft | Prototype |
| Superman - The Man of Steel | EU | 1992-12 |
Sunsoft | Commercial |
| SupraKillminds! | WORLD | 2024 |
1985 Alternativo | Unlicensed |
| Surging Aura | JP | 1995-03-17 |
Sega Enterprises | Commercial |
| Swamp Thing | US | 1992 |
Microsmiths | Prototype |