| Shikinjou | JP | 1991-04 |
Sunsoft | Commercial |
| Shikong Yibian | CN | 1991-12 |
| Unlicensed |
| Shiliu Zhang Mahjong - Xiangyan Meiren Pian | TW | 1992 |
Sun Green | Unlicensed |
| Shiliu Zhang Mahjong II | TW | |
| Unlicensed |
| Shin Changsegi - Ragnacenty | KR | 1995 |
Atlus | Commercial |
| Shin Souseiki Ragnacenty | JP | 1994-06-17 |
Atlus | Commercial |
| Shin Souseiki Ragnacenty | JP | 1994-06-17 |
Atlus | Prototype |
| Shining Force | EU | 1993-07 |
Sega of America | Commercial |
| Shining Force | US | 1993-05 |
Sega of America | Commercial |
| Shining Force | US | 1993-05 |
Sega of America | Prototype |
| Shining Force - Kamigami no Isan | JP | 1992-03 |
Sega of America | Commercial |
| Shining Force II | EU | 1994-09 |
Sega of America | Commercial |
| Shining Force II | US | 1994-10 |
Sega of America | Commercial |
| Shining Force II | US | 1994-10 |
Sega of America | Prototype |
| Shining Force II - Inishie no Fuuin | JP | 1993-10 |
Sega of America | Commercial |
| Shining and the Darkness | JP | 1991-03 |
Sega of America | Commercial |
| Shining in the Darkness | BR | 1991-03 |
Sega of America | Commercial |
| Shining in the Darkness | EU | 1991-11-11 |
Sega of America | Commercial |
| Shining in the Darkness | US | 1991-10 |
Sega of America | Commercial |
| Shinobi III - Return of the Ninja Master | EU | 1993-07 |
Sega of America | Commercial |
| Shinobi III - Return of the Ninja Master | US | 1993-08 |
Sega of America | Commercial |
| Shinobi III - Return of the Ninja Master | US | 1993-08 |
Sega of America | Prototype |
| Shisan Zhang Mahjong - 98 Mei Shaonu | TW | 1998 |
| Unlicensed |
| Shisan Zhang Mahjong - Zhongguo Meinu Pian | TW | 1993 |
| Unlicensed |
| Shiten Myouou | JP | 1990-08 |
Sage's Creation | Commercial |
| Shougi no Hoshi | JP | 1991-10 |
Home Data | Commercial |
| Shove It! ...The Warehouse Game | US | 1990-04 |
DreamWorks | Commercial |
| Show do Milhao | BR | 2001 |
Tec Toy | Commercial |
| Show do Milhao - Volume 2 | BR | 2002 |
Tec Toy | Commercial |
| Shuihu Fengyun Zhuan | TW | 1996 |
Piko Interactive | Unlicensed |
| Shuihu Zhuan | TW | 1996 |
Chuanpu Technologies | Unlicensed |
| Shura no Mon | JP | 1992-08-07 |
Sega Enterprises | Commercial |
| Shylax | WORLD | 2023-10 |
manu2097 | Prototype |
| Side Pocket | EU | 1992-08 |
Data East | Commercial |
| Side Pocket | JP | 1992-12-11 |
Data East | Commercial |
| Side Pocket | KR | 1992-08 |
Data East | Commercial |
| Side Pocket | US | 1992-08 |
Data East | Commercial |
| Silent Hill Genesis | WORLD | 2014 |
Another World | Prototype |
| Sir Ababol | WORLD | 2025-03 |
old_pirate | Unlicensed |
| Skazka | WORLD | 2022-07 |
StevePro Studios | Unlicensed |
| Skeleton Krew | EU | 1995-03 |
Core Design | Commercial |
| Skeleton Krew | US | 1995-05 |
Core Design | Commercial |
| Skitchin' | EU | 1994-03-26 |
Electronic Arts | Commercial |
| Skitchin' | US | 1994-04 |
Electronic Arts | Commercial |
| Skull & Crossbones | US | |
| Demo |
| Slam - Shaq vs. the Legends | US | |
Electronic Arts | Prototype |
| Slap Fight MD | JP | 1993-06-11 |
Toaplan | Commercial |
| Slap Fight MD | JP | 1993-06-11 |
Toaplan | Prototype |
| Slaughter Sport | US | 1991-12-20 |
RazorSoft | Commercial |
| Sleigh Chase | WORLD | 2025-12 |
GeeseBumps | Unlicensed |
| Slime World | JP | 1992-04-30 |
Renovation Products | Commercial |
| Smart Mouse | US | 2017-01 |
Ming Super Chip Electronic | Unlicensed |
| Snail Maze II | WORLD | 2024-06 |
Safety Stoat Studios | Unlicensed |
| Snake Rattle n Roll | EU | 1993-10 |
Sega Enterprises | Commercial |
| Snow Bros. - Nick & Tom | JP | 1993-05 |
Tengen | Commercial |
| Socket | US | 1994 |
Tokai Engineering | Commercial |
| Sol-Deace | US | 1992-03 |
Renovation Products | Commercial |
| Sol-Deace | WORLD | 1992-03 |
Retro-Bit | Commercial |
| Solaris | WORLD | 2015 |
Nendo | Prototype |
| Soldiers of Fortune | US | 1993-11 |
MicroProse | Commercial |
| Soleil | DE | 1994-06 |
Atlus | Commercial |
| Soleil | ES | 1994-06 |
Atlus | Commercial |
| Soleil | EU | 1994-06 |
Atlus | Commercial |
| Soleil | FR | 1994-06 |
Atlus | Commercial |
| Solitaire in Space | WORLD | 2021-03 |
JoeJoeJoeJoe | Prototype |
| Sonic & Knuckles | US | 1994-10-18 |
Sega of America | Commercial |
| Sonic & Knuckles | WORLD | 1994-10-18 |
Sega of America | Commercial |
| Sonic & Knuckles | WORLD | 1994-10-18 |
Sega of America | Prototype |
| Sonic & Knuckles + Sonic 3 | EU | 1994-10 |
Sega Enterprises | Commercial |
| Sonic & Knuckles + Sonic The Hedgehog | US | 1994-10 |
Sega Enterprises | Commercial |
| Sonic & Knuckles + Sonic The Hedgehog 2 | WORLD | 1994-10 |
Sega Enterprises | Commercial |
| Sonic & Knuckles + Sonic The Hedgehog 2 + Sonic The Hedgehog 3 | WORLD | |
Sega | Commercial |
| Sonic & Knuckles + Sonic The Hedgehog 3 | JP | 1994-10 |
Sega Enterprises | Commercial |
| Sonic & Knuckles + Sonic The Hedgehog 3 | KR | 1994-10 |
Sega Enterprises | Commercial |
| Sonic & Knuckles + Sonic The Hedgehog 3 | US | 1994-10 |
Sega Enterprises | Commercial |
| Sonic 3 | EU | 1994-02 |
Sega of America | Commercial |
| Sonic 3D Blast | EU | 1996-11-14 |
Sega Enterprises | Commercial |
| Sonic 3D Blast | EU | 1996-11-14 |
Sega Enterprises | Prototype |
| Sonic 3D Blast | KR | 1996-11 |
Sega Enterprises | Commercial |
| Sonic 3D Blast | KR | 1996-11 |
Sega Enterprises | Prototype |
| Sonic 3D Blast | US | 1996-11-07 |
Sega Enterprises | Commercial |
| Sonic 3D Blast | US | 1996-11-07 |
Sega Enterprises | Prototype |
| Sonic 3D Blast - Director's Cut | WORLD | 1996-11-07 |
Sega | Unlicensed |
| Sonic Compilation | EU | 1995 |
Majesco Entertainment | Commercial |
| Sonic Compilation | KR | 1995 |
Majesco Entertainment | Commercial |
| Sonic Compilation | US | 1995 |
Majesco Entertainment | Commercial |
| Sonic Crackers | US | 1994 |
Sega | Prototype |
| Sonic Eraser | JP | 1991 |
Sega Enterprises | Commercial |
| Sonic Jam 6 | TW | 1998 |
| Unlicensed |
| Sonic Spinball | EU | 1993-11 |
Sega of America | Commercial |
| Sonic Spinball | EU | 1993-11 |
Sega of America | Prototype |
| Sonic Spinball | JP | 1993-12 |
Sega of America | Commercial |
| Sonic Spinball | US | 1993-11 |
Sega of America | Commercial |
| Sonic Spinball | US | 1993-11 |
Sega of America | Prototype |
| Sonic The Hedgehog | EU | 1991-06 |
Sega of America | Commercial |
| Sonic The Hedgehog | EU | 1991-06 |
Sega of America | Prototype |
| Sonic The Hedgehog | JP | 1991-07-26 |
Sega of America | Commercial |
| Sonic The Hedgehog | KR | 1991-06-23 |
Sega of America | Commercial |
| Sonic The Hedgehog | US | 1991-06 |
Sega of America | Commercial |
| Sonic The Hedgehog | US | 1991-06 |
Sega of America | Prototype |