| Shuma Baolong 02 4 | TW | |
| Unlicensed |
| Shuma Baolong 02 5 | TW | |
| Unlicensed |
| Shuma Baolong 2 | CN | |
| Unlicensed |
| Shuma Baolong 3 | CN | |
| Unlicensed |
| Shuma Baolong 9 - Baolong Pian | TW | |
| Unlicensed |
| Shuma Baolong Zhuanji 10 in 1 | TW | |
| Unlicensed |
| Silent Hill 2 - 20th Anniversary Demake | WORLD | |
| Prototype |
| Sir Knight | WORLD | |
| Unlicensed |
| Skelby | WORLD | |
| Unlicensed |
| Skelost | WORLD | 2025-10 |
caseyatkns | Unlicensed |
| Skull Nightmare | WORLD | |
| Unlicensed |
| Skycon | WORLD | |
| Unlicensed |
| Slime Dungeon | WORLD | |
| Unlicensed |
| Slime's Adventure | WORLD | |
| Prototype |
| Sludge & Sorcery | WORLD | |
| Unlicensed |
| Smickeonn - The Game 2 - Virtual Boy Edition | WORLD | |
| Unlicensed |
| Smickeonn - The Game Boy Adventure | WORLD | |
| Unlicensed |
| Smickeonn - The Game Deluxe | WORLD | 2024-03 |
TVMZ Studios | Unlicensed |
| Snake Xenzia | WORLD | |
| Unlicensed |
| Snobow Champion | JP | 2000-03 |
Bottom Up | Commercial |
| Snoopy Tennis | EU | 2001-10 |
Infogrames | Commercial |
| Snoopy Tennis | EU | 2001-04 |
Infogrames | Prototype |
| Snoopy Tennis | JP | 2001-06 |
Infogrames | Commercial |
| Snoopy Tennis | US | 2001-04 |
Infogrames | Commercial |
| Snooze | WORLD | |
| Unlicensed |
| Snow White and the Seven Dwarfs | EU | 2001-11 |
Ubisoft | Commercial |
| Snow White and the Seven Dwarfs | US | 2001-11 |
Ubisoft | Commercial |
| SnowCross | EU | 2001 |
Vatical Entertainment | Commercial |
| Soccer Manager | EU | 2000-07 |
Acclaim Entertainment | Commercial |
| Sofia the Witch - Curse of the Monster Moon | WORLD | 2023-10 |
Jake Macher | Unlicensed |
| Solomon | JP | 2000-09 |
Tecmo | Commercial |
| Sonic Adventure 7 | TW | 1999 |
Makon Soft | Unlicensed |
| Sonic Adventure 8 | TW | 2000 |
Makon Soft | Unlicensed |
| Soreike! Anpanman - 5-tsu no Tou no Ousama | JP | 2000-11 |
Tamsoft | Commercial |
| Soreike! Anpanman - Fushigina Nikoniko Album | JP | 1999-12 |
Tamsoft | Commercial |
| Soukoban Densetsu - Hikari to Yami no Kuni | JP | 1999-12 |
J-Wing | Commercial |
| Soul Getter - Houkago Bouken RPG | JP | 2000-08 |
Micro Cabin | Commercial |
| Soul Void Redux | WORLD | 2023-06 |
| Unlicensed |
| South Park | US | 1999 |
Crawfish Entertainment | Prototype |
| Space Baby | US | |
| Unlicensed |
| Space Fleet | WORLD | |
| Prototype |
| Space Invaders | EU | 1999-10 |
Activision | Commercial |
| Space Invaders | US | 1999-10 |
Activision | Commercial |
| Space Invaders X | JP | 2000-09 |
Activision | Commercial |
| Space Invasion | EU | 2001-03 |
Rocket Games | Unlicensed |
| Space Invasion & Karate Joe | EU | 2001-03 |
Rocket Games | Unlicensed |
| Space Invasion & Painter | EU | 2001-03 |
Rocket Games | Unlicensed |
| Space Marauder | US | 2000-08 |
Agetec | Commercial |
| Space War | WORLD | |
| Prototype |
| Space-Net - Cosmo Blue | JP | 2001-03 |
Imagineer | Commercial |
| Space-Net - Cosmo Neo | JP | |
| Prototype |
| Space-Net - Cosmo Red | JP | 2001-03 |
Imagineer | Commercial |
| Spacestation Silicon Valley | EU | 1999-07 |
Take 2 Interactive | Commercial |
| Spawn | US | 1999-09 |
Konami | Commercial |
| Spectipede | WORLD | |
| Unlicensed |
| Speedy Gonzales - Aztec Adventure | EU | 1999-02 |
Epoch | Commercial |
| Speedy Gonzales - Aztec Adventure | JP | 1999-02 |
Epoch | Prototype |
| Speedy Gonzales - Aztec Adventure | US | 1999-02 |
Epoch | Commercial |
| Spider-Man | EU | 2000-08 |
Activision | Commercial |
| Spider-Man | FR | 2000-09 |
Activision | Commercial |
| Spider-Man | JP | 2001-04 |
Activision | Commercial |
| Spider-Man | US | 2000-08 |
Activision | Commercial |
| Spider-Man 2 - The Sinister Six | EU | 2001-06 |
Activision | Commercial |
| Spider-Man 2 - The Sinister Six | US | 2001-06 |
Activision | Commercial |
| Spider-Man 3 - Movie Version | US | 2004 |
Sintax Technology | Unlicensed |
| Spiky Harold | WORLD | |
| Unlicensed |
| Spirou - The Robot Invasion | EU | 2000-11 |
Ubisoft | Commercial |
| SpongeBob SquarePants - Legend of the Lost Spatula | EU | 2001-05 |
THQ | Commercial |
| SpongeBob SquarePants - Legend of the Lost Spatula | US | 2001-05 |
THQ | Commercial |
| Spy vs Spy | EU | 1999-06 |
Vatical Entertainment | Commercial |
| Spy vs Spy | EU | 1999-06 |
Vatical Entertainment | Prototype |
| Spy vs Spy | JP | 1999-07 |
Vatical Entertainment | Commercial |
| Spy vs Spy | US | 1999-06 |
Vatical Entertainment | Commercial |
| Spy vs Spy | US | 1999-06 |
Vatical Entertainment | Prototype |
| Star Heritage | EU | |
| Prototype |
| Star Hunt | WORLD | |
| Unlicensed |
| Star Ocean - Blue Sphere | JP | 2001-06 |
Enix | Commercial |
| Star Trek | EU | |
| Prototype |
| Star Wars - Yoda Stories | EU | 1999-12 |
THQ | Commercial |
| Star Wars - Yoda Stories | US | 1999-12 |
THQ | Commercial |
| Star Wars Episode I - Obi-Wan's Adventures | EU | 2001 |
THQ | Commercial |
| Star Wars Episode I - Obi-Wan's Adventures | US | 2000-11 |
THQ | Commercial |
| Star Wars Episode I - Racer | EU | 1999-12 |
Nintendo | Commercial |
| Star Wars Episode I - Racer | US | 1999-12 |
Nintendo | Commercial |
| StarFox - Grounded | WORLD | |
| Unlicensed |
| Stars of Zureon | WORLD | |
| Prototype |
| Starseed | WORLD | 2024-02 |
Thalamus Digital Publishing | Unlicensed |
| Starseed 2 | WORLD | 2024-04 |
Thalamus Digital Publishing | Unlicensed |
| Startled 911 | TW | 2001 |
Hitek | Unlicensed |
| Stellar Wars | WORLD | |
| Unlicensed |
| Stranded Kids | EU | 1999-12 |
Konami | Commercial |
| Stratacombo | WORLD | |
| Prototype |
| Stratagem Hero | WORLD | |
| Unlicensed |
| Street Fighter Alpha - Warriors' Dreams | EU | 2000-03 |
Capcom | Commercial |
| Street Fighter Alpha - Warriors' Dreams | EU | 2000-03 |
Capcom | Prototype |
| Street Fighter Alpha - Warriors' Dreams | JP | 2001-03 |
Capcom | Commercial |
| Street Fighter Alpha - Warriors' Dreams | US | 2000-03 |
Capcom | Commercial |
| Street Hero | TW | |
Sachen | Unlicensed |
| Stuart Little - The Journey Home | EU | 2001-09 |
Activision | Commercial |
| Stuart Little - The Journey Home | US | 2001-09 |
Activision | Commercial |