| Scrabble | EU | 2002 |
Ubisoft | Commercial |
| Scrabble Blast! | US | 2005-05 |
Zoo Digital Publishing | Commercial |
| Scrabble Scramble! | EU | 2005-11 |
Zoo Digital Publishing | Commercial |
| Screw Breaker - Goushin DoriRureRo | JP | 2005-09 |
Nintendo | Commercial |
| Scurge - Hive | EU | 2006-10 |
Southpeak Interactive | Commercial |
| Scurge - Hive | US | 2006-10 |
Southpeak Interactive | Commercial |
| Sea Trader - Rise of Taipan | US | 2003-01 |
Jaleco | Commercial |
| Secret Agent Barbie - Royal Jewels Mission | EU | 2002-11 |
Vivendi Universal Games | Commercial |
| Secret Agent Barbie - Royal Jewels Mission | US | 2002-10 |
Vivendi Universal Games | Commercial |
| Sekhmet's Playground | WORLD | 2024-08 |
| Unlicensed |
| Sengoku Kakumei Gaiden | JP | 2003-02 |
Konami | Commercial |
| Sennen Kazoku | JP | 2005-03 |
Nintendo | Commercial |
| Sentouin Yamada Hajime | JP | 2004-10 |
Kids Station | Commercial |
| Serious Sam Advance | EU | 2004-04 |
Global Star Software | Commercial |
| Serious Sam Advance | US | 2004-04 |
Global Star Software | Commercial |
| Shadow - A Parable | WORLD | |
| Unlicensed |
| Shaman King - Legacy of the Spirits - Soaring Hawk | US | 2005-02 |
Konami | Commercial |
| Shaman King - Legacy of the Spirits - Sprinting Wolf | US | 2005-02 |
Konami | Commercial |
| Shaman King - Master of Spirits | EU | 2004-11 |
Konami | Commercial |
| Shaman King - Master of Spirits | US | 2004-11 |
Konami | Commercial |
| Shaman King - Master of Spirits 2 | EU | 2005-08 |
Konami | Commercial |
| Shaman King - Master of Spirits 2 | US | 2005-08 |
Konami | Commercial |
| Shaman King Card Game - Chou Senjiryakketsu 2 | JP | 2002-07 |
King Records | Commercial |
| Shaman King Card Game - Chou Senjiryakketsu 3 | JP | 2002-12 |
King Records | Commercial |
| Shamu's Deep Sea Adventures | EU | 2006 |
Activision | Commercial |
| Shamu's Deep Sea Adventures | US | 2005-11 |
Activision | Commercial |
| Shanghai Advance | JP | 2001-12 |
Sunsoft | Commercial |
| Shantae 2 - Risky Revolution | US | |
| Prototype |
| Shantae Advance - Risky Revolution | WORLD | 2024 |
WayForward Technologies | Commercial |
| Shark Tale | EU | 2004-09 |
Activision | Commercial |
| Shark Tale | IT | 2004-09 |
Activision | Commercial |
| Shark Tale | JP | 2005-03 |
Activision | Commercial |
| Shark Tale | US | 2004-09 |
Activision | Commercial |
| Shaun Palmer's Pro Snowboarder | DE | 2001-11 |
Activision | Commercial |
| Shaun Palmer's Pro Snowboarder | EU | 2001-11 |
Activision | Commercial |
| Shaun Palmer's Pro Snowboarder | US | 2001-11 |
Activision | Commercial |
| Sheep | EU | 2002-03 |
Empire Interactive | Commercial |
| Shifting Gears - Road Trip | US | 2004-04 |
Zoo Digital Publishing | Commercial |
| Shikakui Atama o Maruku Suru. Advance - Kanji, Keisan | JP | 2004-11 |
Rocket Company | Commercial |
| Shikakui Atama o Maruku Suru. Advance - Kokugo, Sansuu, Shakai, Rika | JP | 2004-11 |
Rocket Company | Commercial |
| Shimura Ken no Baka Tonosama - Bakushou Tenka Touitsu Game | JP | 2002-12 |
TDK Core | Commercial |
| Shin Bokura no Taiyou - Gyakushuu no Sabata | JP | 2005-07 |
Konami | Commercial |
| Shin Kisekae Monogatari | JP | 2003-09 |
Marvelous Entertainment | Commercial |
| Shin Megami Tensei | JP | 2003-03 |
Atlus | Commercial |
| Shin Megami Tensei - Devil Children - Honoo no Sho | JP | 2003-09 |
Atlus | Commercial |
| Shin Megami Tensei - Devil Children - Koori no Sho | JP | 2003-09 |
Atlus | Commercial |
| Shin Megami Tensei - Devil Children - Messiah Riser | JP | 2004-11 |
Rocket Company | Commercial |
| Shin Megami Tensei - Devil Children - Puzzle de Call! | JP | 2003-07 |
Atlus | Commercial |
| Shin Megami Tensei Devil Children - Hikari no Sho | JP | 2002-11 |
Atlus | Commercial |
| Shin Megami Tensei Devil Children - Yami no Sho | JP | 2002-11 |
Atlus U.S.A | Commercial |
| Shin Megami Tensei Devil Children - Yami no Sho | JP | 2002-11 |
Atlus U.S.A | Prototype |
| Shin Megami Tensei II | JP | 2003-09 |
Atlus | Commercial |
| Shin Nihon Pro Wrestling - Toukon Retsuden Advance | JP | 2002-03 |
Nintendo | Commercial |
| Shin Sangoku Musou Advance | JP | 2005-03 |
Nintendo | Commercial |
| Shin chan - Aventuras en Cineland | ES | 2005 |
Atari | Commercial |
| Shin chan contra los Munecos de Shock Gahn | ES | 2006-09 |
Atari Europe | Commercial |
| Shingata Medarot - Kabuto Version | JP | 2004-12 |
Imagineer | Commercial |
| Shingata Medarot - Kuwagata Version | JP | 2004-12 |
Rocket Company | Commercial |
| Shining Force - Kuroki Ryuu no Fukkatsu | JP | 2004-08 |
THQ | Commercial |
| Shining Force - Resurrection of the Dark Dragon | EU | 2004-06 |
THQ | Commercial |
| Shining Force - Resurrection of the Dark Dragon | US | 2004-06 |
THQ | Commercial |
| Shining Soul | EU | 2003-09 |
Sega | Commercial |
| Shining Soul | JP | 2003-03 |
Sega | Commercial |
| Shining Soul | US | 2003-09 |
Sega | Commercial |
| Shining Soul II | EU | 2004-04 |
THQ | Commercial |
| Shining Soul II | JP | 2003-07 |
THQ | Commercial |
| Shining Soul II | US | 2004-04 |
THQ | Commercial |
| Shinyaku Seiken Densetsu | JP | 2003-08 |
Nintendo (overseas) | Commercial |
| Shiren Monsters - Netsal | JP | 2004-04 |
Chunsoft | Commercial |
| Shiruike II - Yu Meiren | TW | |
| Unlicensed |
| Shoot for the Moon | WORLD | 2023-12 |
| Unlicensed |
| Shrek - Hassle at the Castle | EU | 2002-10 |
TDK Mediactive | Commercial |
| Shrek - Hassle at the Castle | US | 2002-10 |
TDK Mediactive | Commercial |
| Shrek - Reekin' Havoc | EU | 2003-10 |
TDK Mediactive | Commercial |
| Shrek - Reekin' Havoc | US | 2003-07 |
TDK Mediactive | Commercial |
| Shrek - Smash n' Crash Racing | EU | 2007 |
Activision | Commercial |
| Shrek - Smash n' Crash Racing | US | 2006-11 |
Activision | Commercial |
| Shrek - Super Slam | EU | 2005-10 |
Activision | Commercial |
| Shrek - Super Slam | US | 2005-10 |
Activision | Commercial |
| Shrek - Swamp Kart Speedway | EU | 2002-03 |
TDK Mediactive | Commercial |
| Shrek - Swamp Kart Speedway | US | 2002-03 |
TDK Mediactive | Commercial |
| Shrek 2 | EU | 2004-06 |
Activision | Commercial |
| Shrek 2 | US | 2004-06 |
Activision | Commercial |
| Shrek 2 - Beg for Mercy | EU | 2004-11 |
Activision | Commercial |
| Shrek 2 - Beg for Mercy | US | 2004-10 |
Activision | Commercial |
| Shrek Prezessin | RU | |
| Unlicensed |
| Shrek the Third | EU | 2007-05 |
Activision | Commercial |
| Shrek the Third | US | 2007-05 |
Activision | Commercial |
| Shuma Guaishou - Hongbaoshi Ban | TW | 2003 |
| Unlicensed |
| Sigma Star Saga | EU | 2005-06 |
Atari | Commercial |
| Sigma Star Saga | US | 2005-06 |
Atari | Commercial |
| Sigma Star Saga DX | WORLD | 2026 |
Limited Run Games | Commercial |
| Silent Scope | EU | 2002-09 |
Konami | Commercial |
| Silent Scope | JP | 2002-10 |
Konami | Commercial |
| Silent Scope | US | 2002-09 |
Konami | Commercial |
| Silk to Cotton | JP | 2002-10 |
KiKi | Commercial |
| SimCity 2000 | EU | 2003-11 |
Zoo Digital Publishing | Commercial |
| SimCity 2000 | US | 2003-11 |
Zoo Digital Publishing | Commercial |
| Simple 2960 Tomodachi Series Vol. 1 - The Table Game Collection - Mahjong, Shougi, Hanafuda, Reversi | JP | 2003-03 |
D3 Publisher | Commercial |
| Simple 2960 Tomodachi Series Vol. 2 - The Block Kuzushi | JP | 2003-03 |
D3 Publisher | Commercial |