| SimAnt | 1993 | snes |
| SimAnt - The Electronic Ant Colony | 1993 | snes |
| SimCity 2000 | 2003 | gba |
| SimCity 2000 | 1995 | ps1, saturn |
| SimCity 2000 - The Ultimate City Simulator | 1995 | snes |
| SimTheme Park | 2000 | ps1 |
| Simple 1500 Series Vol. 85 - The Sengoku Bushou - Tenka Touitsu no Yabou | 2002 | ps1 |
| Simple 2000 Series Vol. 103 - The Chikyuu Boueigun Tactics | 2006 | ps2 |
| Simple 2000 Series Vol. 39 - The Boku no Machi-zukuri - Matching Maker++ | 2003 | ps2 |
| Simple 2000 Series Vol. 99 - The Genshijin | 2006 | ps2 |
| Simple DS Series Vol. 24 - The Sensha | 2007 | nds |
| Simulation Zoo | 1996 | ps1 |
| Skeasy | 2016 | wiiu |
| Skulls of the Shogun | 2013 | xbox360 |
| Skulls of the Shogun: Bone-A-Fide Edition | 2015 | ps4 |
| Skyland | 2021 | gba |
| Slappin' Bitches | 2011 | nes |
| Slime Shiyou! | 1996 | ps1 |
| Smelter | 2021 | ps4, xboxone |
| Smite | 2015 | switch, xboxone |
| Soeldnerschild Special | 1999 | ps1 |
| The Software Toolworks' Star Wars Chess | 1994 | segacd |
| Solar Wars | 2001 | nes |
| Solid Force | 1995 | pcengine |
| Solitaire | 1999 | arcade |
| Solitaire in Space | 2021 | genesis |
| Solomon no Kagi - Oujo Rihita no Namida | 1988 | sms |
| Solomon's Key | 2013 | wiiu |
| Sonar Search | 1977 | channelf |
| Sonshi no Heihou DS | 2004 | nds |
| Sotsugyou II FX - Neo Generation | 1994 | pcfx |
| Sotsugyou R - Graduation Real | 1996 | pcfx, ps1 |
| Soukoban | 1989 | gb |
| Soukuu no Tsubasa - Gotha World | 1997 | ps1, saturn |
| South Park - Let's Go Tower Defense Play! | 2009 | xbox360 |
| Space Crew | 2020 | ps4, switch |
| Space Hulk | 2015 | ps3, vita, wiiu |
| Space Hulk: Ascension | 2016 | ps4 |
| Space Hulk: Ascension | 2018 | xboxone |
| Space Hulk: Tactics | 2018 | ps4, xboxone |
| Space Mission | 1982 | arcadia |
| Space Spartans | 1981 | intv |
| Space Warlord Organ Trading Simulator | 2022 | switch |
| SpaceMaster X-7 | 1983 | a2600 |
| Spacejacked | 2018 | ps4, vita |
| Spaceland | 2020 | ps4, xboxone |
| Sparkling Feather | 1997 | pcfx |
| Spectral Force | 1997 | ps1 |
| Spectral Force - Itoshiki Jaaku | 1999 | ps1 |
| Spectral Force 2 | 1998 | ps1 |
| Spectral Souls - Resurrection of the Ethereal Empires | 2005 | psp |
| SpellForce 3 Reforced | 2021 | ps4, xboxone |
| Spikey Walls | 2014 | wiiu |
| Splashy Duck | 2016 | wiiu |
| Spy vs Spy | 1988 | nes |
| Spy vs Spy | 1986 | nes |
| Spy vs Spy | 1985 | sms |
| Stand O'Food | | psp |
| Standard Daisenryaku - Dengekisen | 2004 | ps2 |
| Standard Daisenryaku - Ushinawareta Shouri | 2005 | ps2 |
| Star Control | 1991 | genesis |
| Star Hammer: The Vanguard Prophecy | 2016 | ps4, xboxone |
| Star Trek - Conquest | 2007 | ps2, wii |
| Star Trek - Legacy | 2006 | xbox360 |
| StarCraft 64 | 2000 | n64 |
| Stealth | 1992 | snes |
| SteamWorld Heist | 2015 | 3ds, ps4, switch, vita, wiiu |
| Steampunk Tower 2 | 2020 | ps4 |
| Steamroller | 1984 | col |
| Steel Horizon | 2004 | nds, psp |
| Stella Glow | 2015 | 3ds |
| Stellar Track | 1981 | a2600 |
| Stellaris | 2019 | ps4, xboxone |
| Stone Sling | | g7400 |
| Stop That Roach! | 1994 | gb |
| Stormrise | 2009 | ps3, xbox360 |
| Strawberry Shortcake - Musical Match-Ups | 1983 | a2600 |
| Strip Poker Live | 1995 | cdi |
| Sub Hunt | 1981 | intv |
| Sudden Strike 4 | 2017 | ps4 |
| Sudden Strike 4: European Battlefields Edition | 2018 | xboxone |
| Sudoku & Permudoku | 2016 | wiiu |
| Suikoden - Tendou Hyaku Hachi-sei | 1999 | ps1 |
| Suikoden - Tendou Hyaku Hachi-sei | 1997 | saturn |
| Suikoden - Tenmei no Chikai | 1990 | nes |
| Suikoden - Tenmei no Chikai | 1996 | ps1, saturn |
| Suitang Yingxiong | | nes |
| Sumer | 2018 | switch |
| Summon Night 3 | 2012 | psp |
| Summon Night 5 | 2013 | psp |
| Sunrise Eiyuutan 2 | 2001 | ps2 |
| Sunrise Eiyuutan 3 | 2006 | ps2 |
| Sunrise Eiyuutan R | 2000 | ps2 |
| Super Aoki Ookami to Shiroki Mejika - Genchou Hishi | 1993 | snes |
| Super Battleship - The Classic Naval Combat Game | 1993 | genesis |
| Super Bullet Break | 2022 | switch |
| Super Castles | 1994 | snes |
| Super Conflict | 1993 | snes |
| Super Daisenryaku | 1989 | genesis, pcengine |
| Super Famicom Wars | 1998 | snes, wii, wiiu |