| Sangokushi II | 2000 | ps1 |
| Sangokushi II - Haou no Tairiku | 1990 | nes |
| Sangokushi II for WonderSwan | 2000 | ws |
| Sangokushi III | 1992 | genesis, pcengine, segacd, snes |
| Sangokushi III | 2002 | ps1 |
| Sangokushi IV | 1994 | 32x, 3do, ps1, saturn, snes |
| Sangokushi IV | 2014 | wii |
| Sangokushi IV with Power-Up Kit | 1997 | ps1, saturn |
| Sangokushi IX | 2004 | ps2 |
| Sangokushi IX with Power-Up Kit | 2004 | ps2 |
| Sangokushi IX with Power-Up Kit | 2011 | psp |
| Sangokushi Koumeiden | 1997 | gba, ps1, saturn |
| Sangokushi Returns | 1998 | ps1 |
| Sangokushi Seishi - Tenbu Spirits | 1993 | snes |
| Sangokushi Senki | 2002 | ps2 |
| Sangokushi Senki 2 | 2003 | ps2 |
| Sangokushi Taisen DS | 2007 | nds |
| Sangokushi V | 1997 | ps1, psp |
| Sangokushi V | 1996 | saturn |
| Sangokushi V with Power-Up Kit | 1998 | ps1 |
| Sangokushi VI | 2005 | psp |
| Sangokushi VI with Power-Up Kit | 1999 | dreamcast, ps1 |
| Sangokushi VII | 2001 | ps1, ps2 |
| Sangokushi VII | 2006 | psp |
| Sangokushi VIII | 2007 | psp |
| Sangokushi VIII with Power-Up Kit | 2003 | ps2 |
| Sangokushi for WonderSwan | 1999 | ws |
| Sanguozhi IV | 1995 | ps1, saturn |
| Sanguozhi V | 1996 | genesis |
| Sanguozhi V | 1996 | ps1, saturn |
| Santa Factory | 2015 | wiiu |
| Saru Puncher | 2000 | gbc |
| Saru Saru DS | 2009 | nds |
| Savage Moon | 2008 | ps3 |
| Savage Moon - The Hera Campaign | 2009 | psp |
| Save the Furries | 2012 | wii |
| Schiffe Versenken | 1998 | gb |
| Scrabble Blast! | 2005 | gba |
| Sea Battle | 1980 | a2600, intv |
| Sea Battle | 1998 | gb |
| Sega Ages 2500 Series Vol. 22 - Advanced Daisenryaku - Deutsch Dengeki Sakusen | 2006 | ps2 |
| Seinaru Kana - Orichalcum no Na no Motoni | 2012 | psp |
| Seiryaku Simulation - Inbou no Wakusei - Shancara | 1992 | nes |
| Seisenshi Denshou - Jantaku no Kishi | 1994 | pcengine |
| Sekigahara | 1990 | pcengine |
| Sen Goku Hime 2 Ran - Hyakka, Senran Tatsukaze no Gotoku | | psp |
| Sengoku Hime - Senran ni Mau Otometachi | 2009 | ps2 |
| Sengoku Hime 2 - En - Hyakka, Senran Tatsukaze no Gotoku | 2010 | ps2 |
| Sengoku Hime 7 - Sen'un Tsuranuku Guren no Ishi | 2018 | vita |
| Sengoku Kantou Sangokushi | 1991 | pcengine |
| Sengoku Mugen | 2001 | ps1 |
| Sengoku Tenka Touitsu | 2009 | ps2 |
| Sengoku Tenka Touitsu | 2009 | psp |
| Sengoku no Hasha - Tenkafubu e no Michi | 1995 | snes |
| Senjou no Valkyria 3 - Extra Edition | 2011 | psp |
| Senjou no Valkyria 3 - Unrecorded Chronicles | 2011 | psp |
| Senran | 1996 | ps1 |
| Senryaku Shidan - Tora! Tora! Tora! Rikusen-hen | 2000 | ps1 |
| Sensha Senryaku - Sabaku no Kitsune | 1988 | nes |
| Sentou Kokka - Air Land Battle | 1995 | ps1 |
| Sentou Kokka Kai - Improved | 1997 | ps1 |
| Settlement Colossus | 2012 | nds |
| Sgt. Saunders' Combat! | 1995 | snes |
| Shadow Tactics: Blades of the Shogun | 2017 | ps4, xboxone |
| Shadows of the Tusk | 1998 | saturn |
| Shanghai Mini | 1999 | ngpc |
| Shattered Union | 2005 | xbox |
| Shellshock Live | 2019 | ps4, xboxone |
| Sheltered | 2016 | ps4, switch, xboxone |
| Shengzhan Fengyun | 1991 | genesis |
| Shin Kaitei Gunkan - Koutetsu no Kodoku | 1997 | saturn |
| Shin Master of Monsters Final EX | 2010 | psp |
| Shin Master of Monsters Final EX - Mukunaru Nageki, Tenmei no Saika | | psp |
| Shin Megami Tensei - Devil Children - Messiah Riser | 2004 | gba |
| Shin Sengoku Tenka Touitsu - Gunyuu-tachi no Souran | 2010 | nds |
| Shin Shikoutei - The First Emperor | 1997 | ps1 |
| Shin Theme Park | 1997 | ps1, saturn |
| Shinchou Kouki | 1993 | snes |
| Shingen the Ruler | 1990 | nes |
| Shining Force | 1993 | genesis |
| Shining Force - Kamigami no Isan | 1992 | genesis |
| Shining Force - The Sword of Hajya | 1993 | gg |
| Shining Force Gaiden - Final Conflict | 1995 | gg |
| Shining Force Gaiden II - Jashin no Kakusei | 1993 | gg |
| Shinseiki Yuusha Taisen | 2005 | ps2 |
| Shinten Makai - Generation of Chaos IV | 2004 | ps2 |
| Shinten Makai - Generation of Chaos V | 2005 | ps2 |
| Shockwave | 1991 | nes |
| Shogun | 1988 | nes |
| Shoot the Ball | 2016 | 3ds, wiiu |
| Shouryuu Sangoku Engi | 1996 | ps1, saturn |
| Shura no Mon | 1992 | genesis |
| Shut the Box | 2014 | wiiu |
| Shutsugeki!! Otometachi no Senjou 2 - Amakakeru Shougeki no Kizuna | | psp |
| Shuyaku Sentai Irem Fighter | 1993 | gb |
| Sid Meier's Civilization | 1995 | snes |
| Sid Meier's Civilization - Shin Sekai Shichidai Bunmei | 1996 | ps1, saturn |
| Sid Meier's Civilization Revolution 2 Plus | 2016 | vita |
| Sid Meier's Pirates! | 2005 | psp, wii, xbox |
| Siegecraft Commander | 2017 | ps4, switch, xboxone |