| Egg Venture | 1997 | arcade |
| Egg Venture Deluxe | 1997 | arcade |
| Eight Forces | 1994 | arcade |
| El Fin Del Tiempo | 1981 | arcade |
| El Monstruo de los Globos | 1991 | nes |
| The Elder Scrolls V - Skyrim | 2006 | ps3 |
| Elemental Fighter | | gbc |
| Elemental Gearbolt | 1998 | ps1 |
| Eliminator | 1981 | arcade |
| Elite Forces - Unit 77 | 2009 | nds |
| Elnark no Zaihou | 1987 | nes |
| Empire City: 1931 | 1986 | arcade |
| The Empire Strikes Back | 1985 | arcade |
| Empire of Steel | 1992 | genesis |
| Enchanted Portals | 2023 | ps4 |
| Enclave | 2002 | xbox |
| Encounter at L-5 | 1982 | a2600 |
| The End | 1980 | arcade |
| Endgame | 2002 | ps2 |
| Enemy Front | 2014 | ps3 |
| Enemy Front | 2014 | xbox360 |
| Enemy Territory - Quake Wars | 2008 | ps3, xbox360 |
| Enforce | 1988 | arcade |
| Enigma II | 1981 | arcade |
| Enlisted | 2020 | xboxone |
| Enter the Gungeon | 2016 | ps4, switch |
| Enter the Matrix | 2003 | gc, ps2, xbox |
| Equites | 1984 | arcade |
| Escape from Monster Manor | 1994 | 3do |
| Eschatos | 2012 | ps4, switch, xbox360 |
| Espgaluda | 2003 | arcade, ps2 |
| Espgaluda II | 2005 | arcade, switch |
| Espgaluda II Black Label | | xbox360 |
| Espial | 1983 | a2600 |
| Espial | 1983 | arcade |
| The Essence of War - Glory Days | 2005 | gba |
| Everspace | 2017 | ps4, switch, xboxone |
| Every Extend Extra | 2006 | psp |
| Evil Night | 1998 | arcade |
| The Evil Within - The Executioner | | xbox360 |
| Evolve | 2015 | ps4, xboxone |
| Ex-Ranza | 1993 | genesis |
| ExZeus | 2004 | ps2, wii |
| ExZeus: The Complete Collection | 2021 | ps4, switch, xboxone |
| Excelsior | 1996 | arcade |
| Exed Exes | 2011 | wii |
| Exed Exes | 1985 | arcade |
| Exerion | 1983 | arcade, nes, sg1000 |
| Exerizer | 1987 | arcade |
| Exhumed | 1996 | ps1, saturn |
| Exit the Gungeon | 2020 | ps4, switch |
| Exocet | 1983 | a2600 |
| Exodus | | arcade |
| Exojet | | g7400 |
| Exophobia | 2024 | ps4, switch, xboxone |
| Expendable | 1999 | dreamcast, ps1 |
| The Expendables 2 - Videogame | 2012 | ps3, xbox360 |
| Expert | 1996 | ps1 |
| Explorer | 1982 | arcade |
| Explosive Breaker | 1992 | arcade |
| Extermination | 1987 | arcade |
| Extermination | 1987 | arcade |
| Extermination | 1987 | arcade |
| Exterminator | 1989 | arcade |
| Extra Bright | 1996 | ps1 |
| Extreme Ghostbusters - The Ultimate Invasion | 2004 | ps1 |
| Extreme Hunting | 2004 | arcade |
| Extreme Hunting 2 | 2006 | arcade |
| Exzisus | 1987 | arcade |
| F-15 City War | 1990 | nes |
| F-16 Renegade | 1992 | nes |
| F-X | 1986 | arcade |
| F.E.A.R. - First Encounter Assault Recon | 2007 | ps3 |
| F.E.A.R. - First Encounter Assault Recon | 2006 | xbox360 |
| F.E.A.R. 2 | | ps3 |
| F.E.A.R. 2 - Project Origin | 2009 | ps3, xbox360 |
| F.E.A.R. 3 | 2011 | ps3, xbox360 |
| F.E.A.R. Files | 2007 | xbox360 |
| F/A | 1992 | arcade |
| Faceball | 1993 | pcengine |
| Faceball 2000 | 1991 | gb, gg, snes |
| Falcon | 1980 | arcade |
| Fall Guys: Ultimate Knockout | 2020 | ps4, switch, xboxone |
| Falling Tiles | 2019 | nes |
| Falsion | 1987 | fds |
| Famicom Mini 10 - Star Soldier | 2004 | gba |
| Famicom Mini 19 - Twin Bee | 2004 | gba |
| Fantastic | | arcade |
| Fantastic Journey | 1994 | arcade |
| Fantastic Night Dreams - Cotton | 2000 | ngpc |
| Fantastic Night Dreams - Cotton | 1993 | pcengine |
| Fantastic Spacians | 1979 | arcade |
| Fantasy Land | | arcade |
| Fantasy Zone | 2022 | genesis |
| Fantasy Zone | 1991 | gg |
| Fantasy Zone | 1986 | arcade, nes, pcengine, sms |
| Fantasy Zone | 2008 | arcade |
| Fantasy Zone II - Opa-Opa no Namida | 1988 | nes |
| Fantasy Zone II - Opa-Opa no Namida | | wii |
| Fantasy Zone II - The Tears of Opa-Opa | 2009 | wii |