| Star Blazer | 1983 | arcade |
| Star Control II | 1994 | 3do |
| Star Control II - The Ur-Quan Masters | | 3do |
| Star Fire | 1979 | arcade |
| Star Fire 2 | 1979 | arcade |
| Star Force | 1984 | arcade, nes, sg1000 |
| Star Fox | 1993 | snes |
| Star Gate | 1987 | nes |
| Star Jacker | 1983 | arcade, sg1000 |
| Star Parodier | 1992 | pcengine |
| Star Soldier | 1986 | nes |
| Star Soldier - Vanishing Earth | 1998 | n64 |
| Star Soldier: Vanishing Earth | 1998 | arcade |
| Star Strike HD | 2007 | ps3 |
| Star Trek - Encounters | 2006 | ps2 |
| Star Wars | 1983 | arcade |
| Star Wars | 1994 | arcade |
| Star Wars - Return of the Jedi - Ewok Adventure | 1983 | a2600 |
| StarHawk | 1993 | gb |
| Starblade | 1991 | 3do, arcade, segacd |
| Stardust Galaxy Warriors: Stellar Climax | 2016 | ps4, xboxone |
| Stardust Galaxy Warriors: Stellar Climax | 2020 | ps4 |
| Stargate | 1981 | a2600, arcade, nes |
| Stargate | 1984 | a2600, a5200 |
| Stargunner | 1982 | a2600 |
| Starship Hector | 1990 | nes |
| Starwing | 1993 | snes |
| Starwing - Competition | 1993 | snes |
| State of Anarchy: Master of Mayhem | 2018 | xboxone |
| Steel Empire | 2004 | gba |
| Steel Empire | 1992 | genesis |
| Steel Machine | 1993 | cdi |
| Steel Rain X | 2016 | xboxone |
| Stellar Assault | 1995 | 32x |
| Stellatum | 2019 | ps4, xboxone |
| Stinger | 1987 | nes |
| Stinger | 1983 | arcade |
| Storm Blade | 1996 | arcade |
| Storming Party / Riku Kai Kuu Saizensen | 1986 | arcade |
| Strafe Bomb | 1981 | arcade |
| Straimium Immortaly | 2019 | ps4 |
| Strike Fighter | 1991 | arcade, segacd |
| Strike Force | 1991 | arcade |
| Strike Force Hydra | 2003 | gba |
| Strike Gunner S.T.G | 1991 | arcade, snes |
| Strikers 1945 | 1995 | arcade, ps1, saturn |
| Strikers 1945 | 2022 | ps4 |
| Strikers 1945 II | 2022 | ps4 |
| Strikers 1945 II | 1998 | saturn |
| Strikers 1945 II | 2018 | switch |
| Strikers 1945 III | 2022 | ps4 |
| Strikers 1945 III / Strikers 1999 | 1999 | arcade |
| Strikers 1945 Plus | 1999 | arcade, neogeo |
| Stronghold | 1983 | a2600 |
| Stunt Air | 1983 | arcade |
| Sturmwind | 2013 | dreamcast |
| Sturmwind Ex | 2019 | xboxone |
| Sub-Scan | 1983 | a2600 |
| Submarine | 1985 | arcade |
| Subroc | 1983 | col |
| Subroc-3D | 1982 | arcade |
| Summer Carnival '92 - Recca | 1992 | nes |
| Super Air Zonk - Rockabilly-Paradise | 1993 | pcengine |
| Super Aleste | 1992 | snes |
| Super B-Daman - Battle Phoenix 64 | 1998 | n64 |
| Super Cobra | 1983 | a2600, a5200, col, intv, o2 |
| Super Cobra | 1981 | arcade |
| Super Crate Box | 2019 | switch |
| Super Cross Force | 1983 | col |
| Super Darius | 1990 | pcengine |
| Super Destronaut | 2015 | wiiu |
| Super Dropzone - Intergalactic Rescue Mission | 2003 | gba |
| Super E.D.F | 1991 | snes |
| Super Heli | 1981 | arcade |
| Super Hydorah | 2017 | ps4, switch, vita |
| Super Mega Space Blaster Special Turbo | 2020 | xboxone |
| Super R-Type | 1991 | snes |
| Super SWIV | 1992 | snes |
| Super Smash T.V | 1992 | genesis |
| Super Smash T.V | 1992 | gg, sms |
| Super Spacefortress Macross / Chou-Jikuu Yousai Macross | 1992 | arcade |
| Super Spacefortress Macross II / Chou-Jikuu Yousai Macross II | 1993 | arcade |
| Super Splash | 1993 | arcade |
| Super Star Blast | 2019 | xboxone |
| Super Star Force | 1986 | nes |
| Super Star Fox Weekend | 1993 | snes |
| Super Stardust Delta | 2012 | vita |
| Super Stardust HD | 2007 | ps3 |
| Super Stardust Ultra | 2015 | ps4 |
| Super Strike Gunner | 1992 | snes |
| Super Thunder Blade | 1988 | genesis |
| Super Thunder Blade | 1988 | arcade |
| Super Xevious | 1984 | arcade |
| Super Xevious - Gump no Nazo | 1986 | nes |
| Super Zaxxon | 1982 | arcade |
| Super-X | 1994 | arcade |
| Supercharger 1942 | 1991 | arcade |
| Syvalion | 1988 | arcade, snes |
| T.T Defender | 1980 | arcade |
| Tac/Scan | 1982 | arcade |