| Shikhondo: Soul Eater | 2018 | xboxone |
| Shikigami no Shiro - internal build | 2001 | arcade |
| Shikigami no Shiro II / The Castle of Shikigami II | 2003 | arcade |
| Shikigami no Shiro III | 2006 | arcade |
| Shin Jinrui - The New Type | 1987 | nes |
| Shippu Mahou Daisakusen | 1994 | arcade |
| Shock Troopers | 1997 | arcade, neogeo |
| Shootin' Gallery | 1983 | a2600 |
| Shooting Love 2007 | 2007 | arcade |
| Shooting Love. 10-shuunen - XIIZeal & DeltaZeal | 2009 | xbox360 |
| Shooting Love. 200X | 2009 | xbox360 |
| Shrike Avenger | 1986 | arcade |
| Side Arms - Hyper Dyne | 1986 | arcade |
| Sidewinder | 1989 | nes |
| Sidewinder | 1988 | arcade |
| Silk Worm | 1990 | nes |
| Silk Worm | 1988 | arcade |
| Silpheed | 1993 | segacd |
| Silver Millennium | 1995 | arcade |
| Silver Surfer | 1990 | nes |
| Simple Wii Series Vol. 4 - The Shooting Action | 2007 | wii |
| Sine Mora | 2012 | ps3, vita, xbox360 |
| Sine Mora EX | 2017 | ps4, switch, xboxone |
| Sinistar | 1984 | a2600 |
| Sinistar | 2023 | arcade |
| Sinistron | 1991 | pcengine |
| Sisters Royale | 2020 | ps4 |
| Sisters Royale: Five Sisters Under Fire | 2020 | xboxone |
| Skelagon | 1983 | arcade |
| Skull Fang | 1996 | arcade |
| Skull Fang - Kuhga Gaiden | 1996 | arcade |
| Sky Adventure | 1989 | arcade |
| Sky Alert | 1992 | arcade |
| Sky Alien ~ Assault | 1983 | a2600 |
| Sky Army | 1982 | arcade |
| Sky Bumper | 1982 | arcade |
| Sky Destroyer | 1985 | arcade, nes |
| Sky Fighter | 1990 | sms |
| Sky Fire | 1979 | arcade |
| Sky Force Anniversary | 2016 | ps3, ps4, switch, vita, wiiu, xboxone |
| Sky Force Reloaded | 2017 | ps4, switch, xboxone |
| Sky Jaguar | 1984 | sms |
| Sky Kid | 1985 | arcade, nes |
| Sky Shark | 1989 | nes |
| Sky Shark | 1987 | arcade |
| Sky Skipper | 1981 | arcade |
| Sky Smasher | 1990 | arcade |
| Sky Soldiers | 1988 | arcade |
| Sky Target | 1995 | arcade |
| Sky Wolf | 1987 | arcade |
| Slap Fight | 1986 | arcade |
| Smash T.V | 1990 | arcade, nes, snes |
| Sol Cresta | 2022 | ps4, switch |
| Sol Divide | 2022 | ps4 |
| Sol Divide: Sword Of Darkness | 1997 | arcade |
| Sol-Deace | 1992 | genesis |
| Sol-Feace | 1991 | segacd |
| Solar Assault | 1997 | arcade |
| Solar Assault Revised | 1997 | arcade |
| Solar Crusade | 1999 | cdi |
| Solar Eclipse | 1995 | ps1, saturn |
| Soldier Blade | 1992 | pcengine, wiiu |
| Soldier Blade - Special Version | 1992 | pcengine |
| Soldner-X 2 - Final Prototype | 2010 | ps3, ps4, vita |
| Solite Spirits | 1999 | arcade |
| Sonic Boom | 1987 | arcade |
| Sonic Wings Reunion | 2025 | switch |
| Sorcer Striker | 1993 | arcade, ps4 |
| Sorcer Striker | 1993 | arcade |
| Soukyugurentai / Terra Diver | 1996 | arcade |
| SoulStar | 1994 | segacd |
| Soviet Union 2010 | 2010 | vb |
| Space Armor | 1984 | sg1000 |
| Space Battle Ship Gomorrah | 1990 | arcade |
| Space Harrier | 1985 | arcade |
| Space Harrier II | 1988 | arcade |
| Space Invaders | 1980 | a2600 |
| Space Invaders | 2002 | gba |
| Space Invaders Forever | 2020 | ps4, switch |
| Space Invasion | 2001 | gbc |
| Space Lords | 1992 | arcade |
| Space Manbow | 2014 | wiiu |
| Space Megaforce | 1992 | snes |
| Space Mission | | arcade |
| Space Mountain | 1984 | sg1000 |
| Space Odyssey | 1981 | arcade |
| Space Seeker | 1981 | arcade |
| Space Tunnel | 1982 | a2600 |
| Space War | 1977 | channelf |
| Spaceball Revolution | 2009 | wii |
| Spectrum 2000 | 2000 | arcade |
| Spider Fighter | 1983 | a2600 |
| Splendor Blast | 1985 | arcade |
| Splendor Blast II | 1985 | arcade |
| Spriggan Mark 2 - Re Terraform Project | 1992 | pcengine |
| Spriggan Powered | 1996 | snes |
| Sqoon | 1986 | nes |
| Squadron 51 | | ps4 |
| Squadron 51 | 2022 | xboxone |
| Stagger I | 1998 | arcade |