| Raiden II New / Raiden DX | 1996 | arcade |
| Raiden III | 2005 | arcade, ps2, ps3 |
| Raiden IV | 2007 | arcade, xbox360 |
| Raiden Trad | 1991 | genesis |
| Raiden Trad | 1992 | snes |
| Raiden V | 2016 | xboxone |
| Raiden V: Director's Cut | 2017 | ps4 |
| Raiga - Strato Fighter | 1991 | arcade |
| Rambo - The Video Game | 2013 | ps3, xbox360 |
| Ranger X | 1993 | genesis |
| Rangok Skies | | ps4 |
| Rapid Hero | 1994 | arcade |
| Raumpatrouille | 1983 | a2600 |
| Ray Force | 1993 | arcade |
| Ray Storm | 2011 | arcade |
| RayCrisis | 1998 | arcade |
| RayStorm | 1996 | arcade, ps1 |
| Rayxanber II | 1991 | pcengine |
| Red Baron | 1980 | arcade |
| Red Clash | 1981 | arcade |
| Red Death | 2020 | xboxone |
| Red Hawk | 1997 | arcade |
| Red October | 1993 | snes |
| The Red Star | 2007 | ps2 |
| Redux - Dark Matters | 2014 | dreamcast |
| Rescue | 1982 | arcade |
| Resogun | 2013 | ps4, vita |
| Revenger '84 | 1984 | arcade |
| Rezon | 1991 | arcade |
| RiftStar Raiders | 2018 | ps4, xboxone |
| Rigid Force Redux | 2020 | ps4 |
| Rival Megagun | 2018 | switch, xboxone |
| Rive | 2016 | ps4, switch, wiiu |
| Robo Aleste | 1993 | segacd |
| Robocop | 2009 | arcade |
| Robodemons | 1990 | nes |
| Robot War, Torpedo Alley | 1977 | channelf |
| Robotech - The Macross Saga | 2002 | gba |
| Rock-On | 1989 | pcengine |
| Rogue Aces | 2018 | ps4, vita |
| Run Deep | 1988 | arcade |
| Ryu Jin | 1993 | arcade |
| S.C.A.T. - Special Cybernetic Attack Team | 1991 | nes |
| S.R.D. Mission | 1986 | arcade |
| S.S. Mission | 1992 | arcade |
| SD Gundam Neo Battling | 1992 | arcade |
| SD Kidou Senshi Gundam - V Sakusen Shidou | 1992 | snes |
| SD Kidou Senshi Gundam 2 | 1993 | snes |
| SF-X | 1983 | arcade |
| SOS | 1979 | arcade |
| SOS Game | 1979 | arcade |
| SRD: Super Real Darwin | 1987 | arcade |
| SWiV | 2001 | gbc |
| Sagaia | 1991 | gb |
| Sagaia | 1989 | arcade, genesis, saturn, sms |
| Sagaia | 1991 | genesis |
| Sagak-ui Bimil | 1990 | sms |
| Saint Dragon | 1989 | arcade |
| Salamander | 1986 | arcade, nes |
| Salamander | 1991 | pcengine |
| Salamander 2 | 1996 | arcade |
| Salamander Deluxe Pack Plus | 1997 | saturn |
| Same! Same! Same! | 2015 | arcade |
| Samurai Aces | 2022 | ps4 |
| Samurai Aces | 1993 | arcade |
| Samurai Aces II: Sengoku Blade | 2022 | ps4 |
| Samurai Aces III: Sengoku Cannon | 2022 | ps4 |
| Sand Scorpion | 1992 | arcade |
| Satazius Next | 2020 | dreamcast |
| Satellite 7 | 1985 | sms |
| Satellite Attack | 1981 | o2 |
| Sauro | 1987 | arcade |
| Savage Bees | 1985 | arcade |
| Scion | 1984 | arcade |
| Scorpion | 1982 | arcade |
| Scrabble | 1981 | arcade |
| Scramble Spirits | 1988 | arcade, sms |
| Sea Fighter Poseidon | 1984 | arcade |
| Sea Hawk | 1983 | a2600 |
| Sea Invasion | 1981 | arcade |
| Sea of Dreamland | 1992 | nes |
| Seahawk | 1982 | a2600 |
| Section Z | 1985 | arcade |
| Section-Z | 1987 | fds, nes |
| Sega Strike Fighter | 2000 | arcade |
| Sega-Galaga | 1983 | sg1000 |
| SegaSonic Cosmo Fighter | 1993 | arcade |
| Seicross | 1986 | nes |
| Seirei Senshi Spriggan | 1991 | pcengine |
| Sen Jing - Guardian Storm | 1998 | arcade |
| Sengeki Striker | 1997 | arcade |
| Sengoku Ace | 1993 | arcade |
| Sengoku Blade: Sengoku Ace Episode II / Tengai | 1996 | arcade |
| Senko no Ronde Special | 2006 | arcade |
| Serious Sam - Double D XXL | 2013 | xbox360 |
| Sewer Shark | 1992 | 3do, segacd |
| Sexy Parodius | 1996 | arcade, ps1, saturn |
| Shark | 1975 | arcade |
| Shienryu | 1997 | arcade |
| Shikhondo: Soul Eater | 2018 | ps4 |