| Silver Falls - Undertakers | | wiiu |
| Silver Falls - White Inside Its Umbra | | wiiu |
| Silverfall | 2007 | psp |
| Silviana - Ai Ippai no Little Angel | 1988 | fds |
| Simple 1500 Series Vol. 70 - The War Simulation - Hito no Tsukurishi Monotachi | 2001 | ps1 |
| Simple 1500 Series Vol. 92 - The Tozan RPG - Ginrei no Hasha | 2002 | ps1 |
| Simple 2000 Series Ultimate Vol. 33 - Ururun Quest - Koiyuuki | 2005 | ps2 |
| Simple 2000 Series Vol. 20 - The Dungeon RPG - Shinobi - Mamono no Sumu Shiro | 2002 | ps2 |
| Simple 2000 Series Vol. 21 - The Bishoujo Simulation RPG - Moonlight Tale | 2003 | ps2 |
| Simple 2000 Series Vol. 44 - The Hajimete no RPG - Densetsu no Keishousha | 2004 | ps2 |
| Simple Character 2000 Series Vol. 01 - Kidou Senshi Gundam - The Gunjin Shougi | 2001 | ps1 |
| Sin Segyesuui Migung - Millenniumui Sonyeo | 2014 | 3ds |
| Sindibad - Chitei no Daimakyuu | 1990 | pcengine |
| Sinner: Sacrifice for Redemption | 2018 | ps4, switch |
| Sinner: Sacrifice for Redemption | 2018 | xboxone |
| Siralim | 2016 | ps4, vita |
| Siralim 2 | 2017 | ps4, vita |
| Siralim 3 | 2019 | ps4 |
| Skazka | 2022 | genesis |
| Skellboy Refractured | 2021 | switch |
| Skies of Arcadia | 2000 | dreamcast, gc |
| Sky Rogue | 2020 | xboxone |
| Skyforge | 2017 | switch, xboxone |
| Skylanders - Imaginators | 2016 | ps3 |
| Slap Stick | 1994 | snes |
| Slay the Spire | 2019 | ps4, switch, xboxone |
| Slayer | 1994 | 3do |
| Slayers | 1994 | snes |
| Slayers Royal 2 | 1998 | saturn |
| Slayers Wonderful | 1998 | ps1 |
| Slime Mori Mori Dragon Quest 3 - Daikaizoku to Shippo Dan | 2011 | 3ds |
| Smoke and Sacrifice | 2018 | switch, xboxone |
| Snack World: The Dungeon Crawl – Gold | 2018 | switch |
| Snap Kid's | 2002 | gba |
| Sniper Elite | 2010 | wii |
| Soeldnerschild | 1997 | saturn |
| Sol Bianca | 1990 | pcengine |
| Sol Moonarge | 1994 | pcengine |
| Sol Trigger | 2012 | psp |
| Soleil | 1994 | genesis |
| Solid Link - Dungeon Side | 2000 | ps1 |
| Solid Link - Tower Side | 2000 | ps1 |
| Solid Runner | 1997 | snes |
| Soma Bringer | 2008 | nds |
| Song Master | 1992 | snes |
| Songbringer | 2017 | ps4, switch, xboxone |
| Sonic Chronicles - The Dark Brotherhood | 2008 | nds |
| Sonic Chronicles - Yami Jigen kara no Shinryakusha | 2009 | nds |
| Sora no Kiseki - Material Collection Portable | | psp |
| Sorcer Kingdom | 1992 | genesis |
| Sorcerer's Kingdom | 1993 | genesis |
| Sorcerian | 1990 | genesis, pcengine, wii |
| Sorcerous Stabber Orphen | 2000 | ps2 |
| Sorcery Blade | 2008 | wii |
| Sorcery Saga - Curse of the Great Curry God | 2013 | vita |
| Soreike! Anpanman - Fushigina Nikoniko Album | 1999 | gbc |
| Sorvice | 1998 | saturn |
| Soukou Kihei Votoms - Koutetsu no Gunzei | 1999 | ps1 |
| Soukou no Kihei - Space Griffon | 1999 | dreamcast |
| Soul & Sword | 1993 | snes |
| Soul Blader | 1992 | snes |
| Soul Blazer | 1992 | snes |
| Soul Cradle - Sekai o Kurau Mono | 2007 | ps2 |
| Soul Getter - Houkago Bouken RPG | 2000 | gbc |
| Soul Hackers 2 | 2022 | ps4, xboxone |
| Soul Nomad & the World Eaters | 2007 | ps2 |
| Soul Sacrifice | 2013 | vita |
| Soul Sacrifice Delta | 2014 | vita |
| Soul Saga: Episode 1 | | ps4 |
| Soulmaster | 1998 | ps1 |
| Source of Madness | 2022 | switch |
| Souseiki Gadget Robo | 2008 | nds |
| South Park - The Stick of Truth | 2013 | ps3, ps4, switch, xbox360, xboxone |
| South Park: The Fractured but Whole | 2017 | ps4, switch, xboxone |
| Space-Net - Cosmo Blue | 2001 | gbc |
| Space-Net - Cosmo Neo | | gbc |
| Space-Net - Cosmo Red | 2001 | gbc |
| Sparklite | 2019 | ps4, switch, xboxone |
| Spartan Fist | 2020 | xboxone |
| Spectral Blade | 1999 | ps1 |
| Spectral Force - Genesis | 2009 | nds |
| Spectral Force - Radical Elements | 2004 | ps2 |
| Spectral Force 3 | 2008 | xbox360 |
| Spectral Force 3 - Innocent Rage | 2006 | xbox360 |
| Spectral Gene | 2007 | ps2 |
| Spectral Tower | 1996 | ps1 |
| Spectral Tower II | 1998 | ps1 |
| Spectrobes | 2007 | nds |
| Spectrobes - Beyond the Portals | 2008 | nds |
| Spellspire | 2017 | vita, xboxone |
| Spelunker II - Yuusha e no Chousen | 1987 | nes |
| Spelunky | 2012 | ps3, ps4, vita, xbox360 |
| Spelunky 2 | 2020 | ps4, switch |
| The Speris Legacy | 1996 | cd32 |
| Spiritual Warfare | 1992 | nes |
| Splatterworld - Rick to Kyoufu no Daiou | | nes |
| Square no Tom Sawyer | 1989 | nes |
| Square's Preview 2 | 1997 | ps1 |
| Star Breaker | 1994 | pcengine |
| Star Fox 64 | 2007 | wii |