| Seiken Densetsu - Rise of Mana | 2015 | vita |
| Seiken Densetsu 2 | 1993 | snes |
| Seiken Densetsu 2 | 2014 | wii |
| Seiken Densetsu 3 | 1995 | snes |
| Seikon no Joka - Hikari to Yami no Seioujo | 1997 | ps1 |
| Seima Densetsu 3x3 Eyes | 1993 | segacd |
| Seirei Shinseiki - Fhey Area | 1992 | segacd |
| Seirei Shoukan - Princess of Darkness | 1998 | ps1 |
| Seireiki Rayblade | 2000 | dreamcast, ps1 |
| Seiryuu Densetsu - Monbit | 1991 | pcengine |
| Seisenshi - Saint Paradise - Saikyou no Senshitachi | 1992 | gb |
| Seisou no Amazones | 2013 | 3ds |
| Seiya Monogatari - Anearth Fantasy Stories | 1995 | pcengine |
| Sekai wa Atashi de Mawatteru - Hikari to Yami no Princess | 2009 | psp |
| Sekaiju no Meikyuu IV - Denshou no Kyoshin | 2015 | 3ds |
| Sekaiju no Meikyuu V - Nagaki Shinwa no Hate | 2016 | 3ds |
| Sekaiju no Meikyuu X | 2019 | 3ds |
| Sekaiju to Fushigi no Dungeon | 2015 | 3ds |
| Sekaiju to Fushigi no Dungeon 2 | 2017 | 3ds |
| Selection - Erabareshi Mono | 1989 | gb |
| Selection I & II - Erabareshi Mono & Ankoku no Fuuin | 1998 | gb |
| Selection II - Ankoku no Fuuin | 1992 | gb |
| Seme COM Dungeon - Drururuaga | 2000 | gbc |
| Sengoku Kakumei Gaiden | 2003 | gba |
| Sengoku Ninja-kun | 1991 | gb |
| Sengoku Shura Soul | 2016 | vita |
| Sengoku Turb | 1999 | dreamcast |
| Senjou no Valkyria 2 - Gallia Ouritsu Shikan Gakkou | 2010 | psp |
| Senkai Ibunroku Juntei Taisen - TV Animation Senkaiden Houshin Engi Yori | 2000 | gbc |
| Senkaiden - TV Animation Senkaiden Houshin Engi Yori | 2000 | ws |
| Senkaiden Ni - TV Animation Senkaiden Houshin Engi Yori | 2000 | wsc |
| Senken Kigyouden | 1999 | saturn |
| Senkutsu Katsuryu Taisen - Chaos Seed | 1998 | saturn |
| Senritsu no Stratus | 2011 | psp |
| Sense: A Cyberpunk Ghost Story | 2021 | switch, vita |
| Sephirothic Stories | 2019 | ps4, xboxone |
| The Seven Deadly Sins: Knights of Britannia | 2018 | ps4 |
| Seven Knights: Time Wanderer | 2020 | switch |
| Shachou Eiyuuden | 2000 | ps1 |
| Shadam Crusader - Harukanaru Oukoku | 1992 | gg |
| Shadow Brain | 1991 | nes |
| Shadow Hearts | 2001 | ps2 |
| Shadow Hearts | 2001 | ps2 |
| Shadow Hearts - Covenant | 2004 | ps2 |
| Shadow Hearts - From the New World | 2005 | ps2 |
| Shadow Hearts II | 2004 | ps2 |
| Shadow Hearts II | 2004 | ps2 |
| Shadow Hearts II - Director's Cut | 2004 | ps2 |
| Shadow Madness | 1999 | ps1 |
| Shadow Tower Abyss | 2003 | ps2 |
| Shadowrun | 1994 | genesis |
| Shadowrun | 1996 | segacd |
| Shadowrun | 1993 | snes |
| Shadowrun Returns | 2022 | switch |
| Shadowrun: Dragonfall - Director's Cut | 2022 | switch |
| Shadows: Awakening | 2018 | ps4, xboxone |
| Shadowverse: Champion's Battle | 2020 | switch |
| Shalnor Legends: Sacred Lands | 2018 | xboxone |
| Shaman King - Asu e no Ishi | 2002 | wsc |
| Shaman King - Legacy of the Spirits - Soaring Hawk | 2005 | gba |
| Shaman King - Legacy of the Spirits - Sprinting Wolf | 2005 | gba |
| Shaman King - Master of Spirits | 2004 | gba |
| Shaman King Card Game - Chou Senjiryakketsu 3 | 2002 | gba |
| Shanggu Shen Jian | | nes |
| Shanshan de Hongxing | | nes |
| Shaonian Youxia - Guangming Zhi Shen | | nes |
| Shattered – Tale of the Forgotten King | 2022 | ps4, switch |
| She Diao Yingxiong Zhuan | | nes |
| Shediao Yingxiongzhuan | 2000 | ps1 |
| Shen Gui Chuanqi | | nes |
| Sheng Huo Lie Zhuan | 1991 | nes |
| Shenghua Weiji - Bio Hazard | 2003 | nes |
| Shepherd's Crossing | 2010 | psp |
| Shi no Meikyuu - Labyrinth of Death | 1990 | genesis |
| Shifters | 2002 | ps2 |
| Shikabanegurai no Boukenmeshi | 2022 | ps4, switch |
| Shiki Eiyuuden | 1995 | snes |
| Shikong Yibian | 1991 | genesis |
| Shin Bokura no Taiyou - Gyakushuu no Sabata | 2005 | gba |
| Shin Changsegi - Ragnacenty | 1995 | genesis |
| Shin Ken to Mahou to Gakuen Mono - Toki no Gakuen | 2012 | psp |
| Shin Masou Kishin - Panzer Warfare | 1999 | ps1 |
| Shin Megami Tensei | 1992 | gba, pcengine, ps1, snes |
| Shin Megami Tensei | 1994 | segacd |
| Shin Megami Tensei | 2007 | wii |
| Shin Megami Tensei - Deep Strange Journey | 2017 | 3ds |
| Shin Megami Tensei - Devil Children - Honoo no Sho | 2003 | gba |
| Shin Megami Tensei - Devil Children - Koori no Sho | 2003 | gba |
| Shin Megami Tensei - Devil Children - Kuro no Sho, Aka no Sho | 2002 | ps1 |
| Shin Megami Tensei - Devil Summoner | 2005 | psp |
| Shin Megami Tensei - Devil Summoner - Akuma Zensho | 1996 | saturn |
| Shin Megami Tensei - Devil Summoner - Raidou Kuzunoha vs. the Soulless Army | 2006 | ps2 |
| Shin Megami Tensei - Devil Summoner - Soul Hackers | 2013 | 3ds |
| Shin Megami Tensei - Devil Summoner 2 - Raidou Kuzunoha vs. King Abaddon | 2008 | ps2 |
| Shin Megami Tensei - Devil Survivor | 2009 | nds |
| Shin Megami Tensei - Devil Survivor 2 | 2012 | nds |
| Shin Megami Tensei - Devil Survivor 2 - Record Breaker | 2015 | 3ds |
| Shin Megami Tensei - Devil Survivor Overclocked | 2013 | 3ds |
| Shin Megami Tensei - Digital Devil Saga | 2004 | ps2 |
| Shin Megami Tensei - Digital Devil Saga 2 | 2005 | ps2 |