| Dr. Sudoku | 2006 | gba |
| Dr. Tomy | 1993 | arcade |
| Dragon Dance | 2009 | nds |
| Dragon Dance | 2009 | psp |
| Dragon Punch | 1989 | arcade |
| Dragon Tales - Dragon Wings | 2000 | gbc |
| Dragon World | 1995 | arcade |
| Dragon World 3 / Zhongguo Long 3 / Dungfong Zi Zyu 3 / Chuugokuryuu 3 Special | 1998 | arcade |
| Dragon World 3 EX / Zhongguo Long 3 EX / Dungfong Zi Zyu 3 EX / Chuugokuryuu 3 EX | 2000 | arcade |
| Dragon World II | 1997 | arcade |
| Dragon's Cache | 2021 | a7800 |
| Draw 2 Survive | 2016 | wiiu |
| Drawn to Life: Two Realms | 2020 | switch |
| Dream Chronicles | 2009 | nds, ps3, xbox360 |
| Dream Dog Dilemma | 2021 | nes |
| Dream Square - Hinagata Akiko | 1997 | saturn |
| DreamWorks Shrek Forever After | 2010 | ps3, wii |
| Dreamals: Dream Quest | 2016 | wiiu, xboxone |
| Dreamwalker | 2018 | vita |
| Dreii | 2016 | ps4, vita |
| Drill Sergeant Mindstrong | 2009 | wii |
| Drip | 2021 | nes |
| Droll Ball | 2025 | nes |
| Drop It - Block Paradise! | 2017 | wiiu |
| Drop Off | 2007 | wii |
| Drop Rock Hora Hora | | wii |
| Dropcast | 2008 | nds |
| Droplitz | 2009 | ps3, xbox360 |
| Duck Dodgers Starring Daffy Duck | 2000 | n64 |
| Dung Fong Zi Zyu | 1995 | arcade |
| Dungeon Explorer | 2022 | nes |
| Dungeon Master - Theron's Quest | 1992 | pcengine |
| Dungeon Master Nexus | 1998 | saturn |
| Dungfong Zi Zyu II | 1997 | arcade |
| Dying - Reborn | 2017 | vita |
| Dying: Reborn | 2017 | xboxone |
| DynaMike | | gbc |
| Dynablaster | 1991 | gb, nes |
| Dynamite Fishing: World Games | 2016 | xboxone |
| Echochrome | 2008 | ps3, psp |
| Echochrome - Expansion | 2009 | psp |
| Echochrome - Mugen Kairou | 2008 | psp |
| Echochrome II | 2010 | ps3 |
| Echochrome Micro | 2008 | psp |
| Echoshift | 2009 | psp |
| Eddie's Puzzle Time | 1994 | gb |
| Eets - Chowdown | 2007 | xbox360 |
| Egg Hunt | 1995 | arcade |
| Egg Mania - Tsukande! Mawashite! Dossun Puzzle!! | 2002 | ps2, xbox |
| Egg World | 2023 | nes |
| Egger Land | 1987 | fds |
| Egger Land - Souzou e no Tabidachi | 1988 | fds |
| Eggerland - Meikyuu no Fukkatsu | 1988 | nes |
| Eggo Mania | 2002 | gba, gc, ps2, xbox |
| Ejihon Tantei Jimusho | 1995 | arcade |
| El Bloque Magico | 1991 | nes |
| El Tetris Un Magico Desafio | 1999 | ps1 |
| Elansar | 2015 | dreamcast |
| Elebits - Kai to Zero no Fushigi na Tabi | 2008 | nds |
| Elebits - Kaiwa Zeroui Sinbihan Yeohaeng | 2008 | nds |
| Eledive | 2012 | vita |
| Elefunk | 2008 | ps3 |
| Elfin | 1999 | arcade |
| Elvenland | 2004 | nds |
| Emerald Mines | 1994 | cd32 |
| Emeraldia | 1993 | arcade, wii |
| Emojikara - A Clever Emoji Match Game | 2016 | wiiu |
| Empire of Atlantis | 2006 | ps2 |
| Energy Balance | 2017 | vita |
| Energy Cycle | 2016 | vita, xboxone |
| Energy Cycle Edge | 2018 | vita, xboxone |
| Energy Invasion | 2018 | vita |
| English Training - Have Fun Improving Your Skills | 2006 | nds |
| Enigmacore | 2015 | nes |
| Enjoy Your Massage! | 2010 | wii |
| Epic Word Search Collection | 2020 | vita |
| Epic Word Search Collection 2 | 2020 | vita |
| Equilibrio | 2009 | wii |
| Erotictac/Tactic | 1990 | arcade |
| Escape Plan | 2012 | ps4, vita |
| Escape Plan - Director's Cut | 2012 | vita |
| Escape Plan - The Director's Cut | 2012 | vita |
| Escape Sequence | 2021 | xboxone |
| Escape from Flooded Ruins | 2021 | nes |
| Escape the Museum | 2004 | nds |
| EscapeVektor | 2012 | 3ds, vita |
| Essential Sudoku DS | 2006 | nds |
| Evolution - Dino Dudes | 1994 | jaguar |
| Exit | 2005 | nds, psp |
| Exit | 2007 | xbox360 |
| Exit 2 | 2007 | psp |
| Exit 2 | 2009 | xbox360 |
| Exodus - Journey to the Promised Land | 1991 | gb, genesis, nes |
| Explosive Jake | 2020 | vita |
| EyeToy - Operation Spy | 2005 | ps2 |
| FA Tetris | 1990 | sms |
| Fabulous Finds | 2004 | nds |
| Face Kitchen | 1992 | cdi |
| Factotum 90 | 2016 | vita, xboxone |
| Fading Shadows | 2008 | psp |