| Cookie & Cream | 2007 | nds |
| Cool Ball | 1991 | gb |
| Cool Spot | 1993 | gb, genesis, gg, sms, snes |
| Cool World | 1992 | gb, nes, snes |
| Cooly Skunk | 1996 | ps1 |
| Coqui the Game | 2017 | wiiu |
| Cosmic Crisis | 1983 | col |
| Cosmic Spacehead | 1993 | genesis, gg, nes, sms |
| Cosmo Police Galivan | 1988 | nes |
| Cosmo Police Galivan | 1985 | arcade |
| The Cowlitz Gamers' Lost Adventure | 2020 | nes |
| Crap Job! | 2022 | nes |
| Crash - Mind over Mutant | 2008 | nds, ps2, psp, wii, xbox360 |
| Crash Advance IV | 2006 | gba |
| Crash Bandicoot - The Huge Adventure | 2002 | gba |
| Crash Bandicoot - The Wrath of Cortex | 2001 | gc, ps2, xbox |
| Crash Bandicoot 2 - N-Tranced | 2003 | gba |
| Crash Bandicoot 4 - Sakuretsu! Majin Power | 2002 | xbox |
| Crash Bandicoot 4: It's About Time | 2020 | ps4, switch, xboxone |
| Crash Bandicoot Advance | 2002 | gba |
| Crash Bandicoot Advance - Wakuwaku Tomodachi Daisakusen! | 2004 | gba |
| Crash Bandicoot Fusion | 2004 | gba |
| Crash Bandicoot N. Sane Trilogy | 2017 | ps4, switch, xboxone |
| Crash Dummy - Dr. Zabu o Sukuidase | 1994 | snes |
| Crash of the Titans | 2007 | gba, nds |
| Crayon Shin-chan - Arashi o Yobu Cinemaland Kachinko Gachinko Daikatsugeki! | 2008 | nds |
| Crayon Shin-chan - Arashi o Yobu Cinemaland no Daibouken! | 2004 | gba |
| Crayon Shin-chan - Arashi o Yobu Enji | 1994 | genesis |
| Crayon Shin-chan - Arashi o Yobu Nendororoon Daihenshin! | 2009 | nds |
| Crayon Shin-chan - Ora to Shiro wa Otomodachi Da yo | 1993 | gb |
| Crayon Shin-chan 2 - Daimaou no Gyakushuu | 1994 | snes |
| Crayon Shin-chan 2 - Ora to Wanpaku Gokko Dazo | 1993 | gb |
| Crayon Shin-chan 4 - Ora no Itazura Daihenshin | 1994 | gb |
| Crayon Shin-chan DS - Arashi o Yobu Nutte Crayoon Daisakusen! | 2007 | nds |
| Crazy Chase | 2002 | gba |
| Crazy Chicken Tales | 2009 | wii |
| Crazy Climber | 2011 | astrocade |
| Crazy Kong | 1981 | arcade |
| Crazy Kong Part II | 1981 | arcade |
| Creogic - The Game | 2025 | nes |
| Criatura | 2023 | genesis |
| Croc | 2000 | gbc |
| Croc - 25th Anniversary Edition | | gbc |
| Croc 2 | 2001 | gbc |
| Croc! Pau-Pau Island | 1998 | saturn |
| Cross Wiber - Cyber Combat Police | 1990 | pcengine |
| Cruisin | 1985 | arcade |
| Crush | 2007 | psp |
| CrushBorgs | 2022 | xboxone |
| Curse Crackers: For Whom the Belle Toils | 2023 | switch |
| Cursed Castilla | 2019 | switch |
| Cybarian - The Time Traveling Warrior | 2021 | vita |
| Cyber Cross | 1989 | pcengine |
| Cyber Police - ESWAT | 1990 | genesis |
| Cyber Shadow | 2021 | switch |
| The Cyber Shinobi | 1990 | sms |
| Cyber-Lip | 1995 | neogeocd |
| Cybernator | 2014 | wiiu |
| Cycle Maabou | 1984 | arcade |
| CycloDS Evolution | 2004 | nds |
| DABG - Double Action Blaster Guys | 2013 | nes |
| DK - Jungle Climber | 2007 | nds, wiiu |
| DK - King of Swing | 2005 | gba |
| Daffy Duck - Fowl Play | 1999 | gbc |
| Daffy Duck - Subette Koron de Oogane Mochi | 2000 | gbc |
| Daffy Duck - The Marvin Missions | 1993 | snes |
| Daffy Duck in Hollywood | 1994 | gg, sms |
| Daggerhood | 2019 | ps4, vita, xboxone |
| Dai Makaimura | | wii |
| Daiku no Gen-san | 1991 | nes |
| Daiku no Gen-san - Ghost Building Company | 1992 | gb |
| Daiku no Gen-san - Kachikachi no Tonkachi ga Kachi | 2000 | gbc |
| Daiku no Gensan | 1990 | arcade |
| Daimakaimura | 1988 | arcade, genesis |
| Damsel | 2019 | ps4, xboxone |
| Dandara | 2018 | ps4, switch, xboxone |
| Danny Phantom - The Ultimate Enemy | 2005 | gba |
| Dao Shuai - Master Chu | 1989 | nes |
| Dark | 2022 | nes |
| Dark Castle | 1991 | cdi, genesis |
| Dark Savior | 1996 | saturn |
| Dark Tower | 1992 | arcade |
| Darkwing Duck | 1992 | gb, nes |
| Darkwing Duck | 2012 | genesis |
| Darkwing Duck | 1992 | pcengine |
| Das Geheimnis der Happy Hippo-Insel | 2001 | gbc |
| Dash Galaxy in the Alien Asylum | 1990 | nes |
| Dashin' Desperadoes | 1993 | genesis |
| Dashosaur DX | 2025 | gbc |
| David Crane's A Boy and His Blob - Trouble on Blobolonia | 1990 | nes |
| David Crane's Pitfall II - Lost Caverns | 1983 | a2600, a5200 |
| David Crane's The Rescue of Princess Blobette | 1989 | gb |
| Daxter | 2006 | psp |
| De Blob | 2017 | ps4, switch, xboxone |
| De Blob | 2008 | wii |
| De Blob 2 | 2018 | ps4 |
| De Blob 2 | 2018 | switch, xboxone |
| De Mambo | 2017 | switch |
| Dead Fox | 1990 | nes |
| Deadcore | 2017 | ps4, xboxone |