| Mega Man Xtreme 2 | 2001 | gbc |
| Mega Man ZX | 2006 | nds |
| Mega Man ZX - Advent | 2007 | nds |
| Mega Man Zero | 2002 | gba |
| Mega Man Zero 4 | 2015 | wiiu |
| Mega Man Zero Collection | 2010 | nds |
| Mega Man Zero/ZX Legacy Collection | 2020 | ps4, switch, xboxone |
| Mega Man: Dual Override | | ps4 |
| Mega Mindy | 2009 | nds |
| Mega Slow Mole | 2023 | genesis |
| Mega Turrican | 1994 | genesis |
| Mega Turrican | 1994 | genesis |
| Mega Twins | 1990 | arcade |
| Megaman Zero 2 | 2003 | gba |
| Megaman Zero 3 | 2004 | gba |
| Megaman Zero 4 | 2005 | gba |
| Meikyuu Kumikyoku - Milon no Daibouken | 1986 | nes |
| Meikyuu Kumikyoku - Milon no Daibouken | 2014 | wii |
| Mekabolt | 2019 | vita |
| Mekabolt | 2019 | xboxone |
| Mekazoo | 2016 | ps4, xboxone |
| Melbits World | 2018 | ps4 |
| Mello Yello Q*bert | 1982 | arcade |
| Meme Run | 2014 | wiiu |
| Memorial Series - Sunsoft Vol. 2 | 2001 | ps1 |
| Memorial Series - Sunsoft Vol. 4 | 2002 | ps1 |
| Memorial Series - Sunsoft Vol. 5 | 2002 | ps1 |
| Men in Black | 1998 | snes |
| Men in Black - The Series | 2001 | gba |
| Men in Black - The Series | 1998 | gbc |
| Men in Black 2 - The Series | 2000 | gbc |
| Menace Beach | 1990 | nes |
| Mercury Hg | 2011 | ps3, xbox360 |
| Merlin | 2001 | gbc |
| The Messenger | 2018 | ps4, switch |
| MetaFight EX | 2000 | gbc |
| Metagal | 2019 | vita |
| Metal Flame - Psy Buster | 1990 | nes |
| Metal Force | 1993 | nes |
| Metal Morph | 1994 | snes |
| Metal Saver | 1994 | arcade |
| Metal Slug | 1996 | neogeocd |
| Metal Slug - Super Vehicle-001 | 1997 | saturn |
| Metal Slug 2 | 1998 | neogeocd |
| Metal Slug 3 | 2022 | arcade |
| Metal Slug Warfare | 2021 | genesis |
| Metal Slug X - Super Vehicle-001 | 1999 | arcade, neogeo |
| Metal Slug X - Super Vehicle-001 | 2021 | arcade |
| Metal Storm | 1991 | nes |
| Metal Warriors | 1995 | snes |
| MetalMech - Man & Machine | 1990 | nes |
| Metalgun Slinger | 2002 | gba |
| Metrico | 2014 | vita |
| Metrico+ | 2016 | ps4, xboxone |
| Metroid - Samus Returns | 2017 | 3ds |
| Metroid Fusion | 2002 | gba, wiiu |
| Michael Jackson's Moonwalker | 1990 | arcade |
| Mick & Mack as the Global Gladiators | | gb |
| Mick & Mack as the Global Gladiators | 1992 | genesis |
| Mick & Mack as the Global Gladiators | 1993 | nes |
| Mickey Mania | 1994 | genesis, ps1, segacd, snes |
| Mickey Mania 7 | 1997 | nes |
| Mickey Mouse | 1991 | gb |
| Mickey Mouse - Dream Balloon | 1992 | nes |
| Mickey Mouse - Fushigi no Kuni no Daibouken | 1987 | nes |
| Mickey Mouse Densetsu no Oukoku - Legend of Illusion | 1995 | gg |
| Mickey Mouse II | 1991 | gb |
| Mickey Mouse III - Yume Fuusen | 1992 | nes |
| Mickey Mouse IV - Mahou no Labyrinth | 1993 | gb |
| Mickey Mouse no Castle Illusion | 1991 | gg |
| Mickey Mouse no Mahou no Crystal | 1993 | gg |
| Mickey Mousecapade | 1988 | nes |
| Mickey no Tokyo Disneyland Daibouken | 1994 | snes |
| Mickey to Donald - Magical Adventure 3 | 1995 | snes |
| Mickey to Donald no Magical Quest 3 | 2003 | gba |
| Mickey to Minnie no Magical Quest 2 | 2003 | gba |
| Mickey's Chase | 1992 | gb |
| Mickey's Dangerous Chase | 1991 | gb |
| Mickey's Jigsaw Puzzles | 1994 | snes |
| Micro Knight IV | | nes |
| Micro Mages | 2019 | nes |
| Mighty Bomb Jack | 1992 | nes |
| Mighty Bomb Jack | 1986 | nes |
| Mighty Gunvolt | 2014 | 3ds |
| Mighty Gunvolt Burst | 2017 | switch |
| Mighty Morphin Power Rangers: Rita's Rewind | 2024 | ps4 |
| Mighty No.9 | 2016 | ps3, ps4, wiiu, xbox360, xboxone |
| Mighty Switch Force! Collection | 2019 | ps4, xboxone |
| Miles & Kilo | 2019 | ps4, vita |
| Miles & Kilo | 2019 | xboxone |
| Milon no Meikyuu Kumikyoku | 1993 | gb |
| Milon's Secret Castle | 1988 | gb, nes |
| Mine Shaft | 2012 | nes |
| Miner 2049er Starring Bounty Bob | 1992 | gb |
| Miner Mole | 2025 | genesis |
| Mini-Mario & Friends - amiibo Challenge | 2016 | 3ds |
| Miniplanets | 2020 | genesis |
| Minna de Uchuu Tour - ChariSou DX2 | 2015 | wiiu |
| Minon - Everyday Hero | 2009 | wii |
| Miracle Adventure of Esparks - Ushinawareta Seiseki Perivron | 1992 | gb |