| Golden Axe Warrior | Master System | EU | 1991-05 |
| Heavyweight Champ | Master System | EU | 1991-05 |
| Michael Jackson's Moonwalker | Master System | US | 1991-05 |
| Bonanza Bros | Mega Drive / Genesis | KR | 1991-05 |
| PGA Tour Golf | Mega Drive / Genesis | EU | 1991-05 |
| Wardner | Mega Drive / Genesis | US | 1991-05 |
| Warrior of Rome | Mega Drive / Genesis | US | 1991-05 |
| Burning Fight | Neo Geo AES | US | 1991-05 |
| Beetlejuice | Nintendo Entertainment System | US | 1991-05 |
| Family Feud | Nintendo Entertainment System | US | 1991-05 |
| Flight of the Intruder | Nintendo Entertainment System | US | 1991-05 |
| L'Empereur | Nintendo Entertainment System | JP | 1991-05 |
| Monopoly | Nintendo Entertainment System | US | 1991-05 |
| Nantettatte!! Baseball + Nantettatte!! Baseball - Ko-Game Cassette - '91 Kaimaku Hen | Nintendo Entertainment System | JP | 1991-05 |
| Palamedes II - Star Twinkle, Hoshi no Mabataki | Nintendo Entertainment System | JP | 1991-05 |
| Phantom Air Mission | Nintendo Entertainment System | ES | 1991-05 |
| Tetrastar - The Fighter | Nintendo Entertainment System | JP | 1991-05 |
| The Rocketeer | Nintendo Entertainment System | US | 1991-05 |
| Times of Lore | Nintendo Entertainment System | US | 1991-05 |
| Parasol Stars - The Story of Bubble Bobble III | PC Engine / TurboGrafx-16 | US | 1991-05 |
| Cocoron | Nintendo Entertainment System | JP | 1991-05-03 |
| Kitchen Panic | Game Boy | JP | 1991-05-10 |
| Sanrio Carnival | Game Boy | JP | 1991-05-11 |
| Ippatsu Gyakuten! DX Bakenou | Game Boy | JP | 1991-05-17 |
| Rubble Saver | Game Boy | JP | 1991-05-17 |
| Bonanza Bros | Mega Drive / Genesis | JP | 1991-05-17 |
| Fuzzical Fighter | Nintendo Entertainment System | JP | 1991-05-17 |
| Super Professional Baseball | Super Nintendo Entertainment System | JP | 1991-05-17 |
| G Arms - Operation Gundam | Game Boy | JP | 1991-05-18 |
| Burning Fight | Neo Geo AES | ? | 1991-05-20 |
| Game Boy Wars | Game Boy | JP | 1991-05-21 |
| Asmik-kun World 2 | Game Boy | JP | 1991-05-24 |
| Snow Bros. Jr | Game Boy | JP | 1991-05-24 |
| Snow Bros. Jr | Game Boy | WORLD | 1991-05-24 |
| Mappy | Game Gear | JP | 1991-05-24 |
| Metal Max | Nintendo Entertainment System | JP | 1991-05-24 |
| Hatris | PC Engine / TurboGrafx-16 | JP | 1991-05-24 |
| Ultra Box 4-gou | PC Engine / TurboGrafx-16 | JP | 1991-05-24 |
| Drakkhen | Super Nintendo Entertainment System | EU | 1991-05-24 |
| Drakkhen | Super Nintendo Entertainment System | JP | 1991-05-24 |
| Drakkhen | Super Nintendo Entertainment System | WORLD | 1991-05-24 |
| Gdleen | Super Nintendo Entertainment System | JP | 1991-05-28 |
| Shadowgate | Nintendo Entertainment System | EU | 1991-05-30 |
| Shadowgate | Nintendo Entertainment System | FR | 1991-05-30 |
| Shadowgate | Nintendo Entertainment System | DE | 1991-05-30 |
| Shadowgate | Nintendo Entertainment System | SE | 1991-05-30 |
| The Adventures of Rad Gravity | Nintendo Entertainment System | EU | 1991-05-30 |
| Legend - Ashita e no Tsubasa | Game Boy | JP | 1991-05-31 |
| Fire Mustang | Mega Drive / Genesis | JP | 1991-05-31 |
| Zero Wing | Mega Drive / Genesis | JP | 1991-05-31 |
| Zero Wing | Mega Drive / Genesis | WORLD | 1991-05-31 |
| Egypt | Nintendo Entertainment System | JP | 1991-05-31 |
| Pomping World | PC Engine / TurboGrafx-16 | JP | 1991-05-31 |
| Crime Fighters 2 | Arcade | JP | 1991-06 |
| D. D. Crew | Arcade | JP | 1991-06 |
| D. D. Crew | Arcade | US | 1991-06 |
| D. D. Crew | Arcade | WORLD | 1991-06 |
| Ghox | Arcade | ? | 1991-06 |
| Rail Chase | Arcade | JP | 1991-06 |
| Rail Chase | Arcade | WORLD | 1991-06 |
| Riot City | Arcade | JP | 1991-06 |
| Road Riot 4WD | Arcade | ? | 1991-06 |
| Bo Jackson - Two Games in One | Game Boy | US | 1991-06 |
| Caesars Palace | Game Boy | EU | 1991-06 |
| Caesars Palace | Game Boy | US | 1991-06 |
| Choplifter II - Rescue & Survive | Game Boy | EU | 1991-06 |
| Choplifter II - Rescue & Survive | Game Boy | US | 1991-06 |
| Magical Taruruuto-kun | Game Boy | JP | 1991-06 |
| Nintendo World Cup | Game Boy | US | 1991-06 |
| Shin Nihon Pro Wrestling - Toukon Sanjuushi | Game Boy | JP | 1991-06 |
| Skate or Die - Tour de Thrash | Game Boy | US | 1991-06 |
| Sneaky Snakes | Game Boy | US | 1991-06 |
| Soccer | Game Boy | JP | 1991-06 |
| Spud's Adventure | Game Boy | US | 1991-06 |
| Tail 'Gator | Game Boy | US | 1991-06 |
| Tail 'Gator | Game Boy | WORLD | 1991-06 |
| Columns | Game Gear | EU | 1991-06 |
| Factory Panic | Game Gear | EU | 1991-06 |
| Factory Panic | Game Gear | BR | 1991-06 |
| G-LOC - Air Battle | Game Gear | EU | 1991-06 |
| Ganbare Gorby! | Game Gear | JP | 1991-06 |
| Revenge of Drancon | Game Gear | US | 1991-06 |
| Revenge of Drancon | Game Gear | BR | 1991-06 |
| Wonder Boy | Game Gear | EU | 1991-06 |
| Psychic World | Master System | EU | 1991-06 |
| Psychic World | Master System | BR | 1991-06 |
| Strider | Master System | US | 1991-06 |
| Strider | Master System | BR | 1991-06 |
| Batman - The Video Game | Mega Drive / Genesis | US | 1991-06 |
| Ka-Ge-Ki - Fists of Steel | Mega Drive / Genesis | US | 1991-06 |
| Phantasy Star III - Generations of Doom | Mega Drive / Genesis | US | 1991-06 |
| Sonic The Hedgehog | Mega Drive / Genesis | EU | 1991-06 |
| Sonic The Hedgehog | Mega Drive / Genesis | US | 1991-06 |
| Sonic The Hedgehog | Mega Drive / Genesis | WORLD | 1991-06 |
| Street Smart | Mega Drive / Genesis | US | 1991-06 |
| Thunder Fox | Mega Drive / Genesis | US | 1991-06 |
| Twin Cobra - Desert Attack Helicopter | Mega Drive / Genesis | US | 1991-06 |
| Wings of Wor | Mega Drive / Genesis | US | 1991-06 |
| Wrestle War | Mega Drive / Genesis | EU | 1991-06 |
| Eight Man | Neo Geo AES | ? | 1991-06 |