| Rockman EXE 4.5 - Real Operation | JP | 2016-01 |
Capcom | Commercial |
| Resident Evil 4 - Wii Edition | EU | 2016-02 |
Capcom | Commercial |
| Resident Evil 4 - Wii Edition | JP | 2016-02 |
Capcom | Commercial |
| Resident Evil 4 - Wii Edition | US | 2016-02 |
Capcom | Commercial |
| Replay - VHS is Not Dead | EU | 2016-02-25 |
Neko Entertainment | Commercial |
| Replay - VHS is Not Dead | US | 2016-02-25 |
Neko Entertainment | Commercial |
| Run Run and Die | EU | 2016-04-28 |
EnjoyUp Games | Commercial |
| Reptilian Rebellion | EU | 2016-05-05 |
Herrero Games | Commercial |
| Rynn's Adventure - Trouble in the Enchanted Forest | US | 2016-05-26 |
Arcane Four Studios | Commercial |
| Run Run and Die | US | 2016-06-16 |
EnjoyUp Games | Commercial |
| Rubik's Cube | EU | 2016-06-23 |
Cypronia | Commercial |
| Rubik's Cube | US | 2016-06-23 |
Cypronia | Commercial |
| R-Type | EU | 2016-07 |
Konami Digital Entertainment | Commercial |
| R-Type | JP | 2016-07 |
Konami Digital Entertainment | Commercial |
| R-Type | US | 2016-07 |
Konami Digital Entertainment | Commercial |
| Reptilian Rebellion | US | 2016-07-14 |
Herrero Games | Commercial |
| Rorrim | EU | 2016-09-08 |
Nitrolic Games | Commercial |
| Rorrim | US | 2016-09-08 |
Nitrolic Games | Commercial |
| Rittai Picross | JP | 2016-10 |
Nintendo | Commercial |
| Retro Road Rumble | US | 2016-10-20 |
Sketchy Coyote Interactive | Commercial |
| Rhythm Heaven Fever | US | 2016-11 |
Nintendo | Commercial |
| Run Run And Die | JP | 2016-12-14 |
EnjoyUp Games | Commercial |
| Radiantflux - Hyperfractal | EU | 2016-12-22 |
TACS Games | Commercial |
| Radiantflux - Hyperfractal | US | 2016-12-22 |
TACS Games | Commercial |