| Himehibi - New Princess Days!! Zoku! Nigakki Portable | JP | 2010-02 |
Takuyo | Commercial |
| Hello Kitty - Puzzle Party | EU | 2010-02-19 |
Ubisoft | Commercial |
| Harvest Moon - Hero of Leaf Valley | EU | 2010-04 |
Natsume | Commercial |
| Harvest Moon - Sugar Village and Everyone's Wish | KR | 2010-04 |
Natsume | Commercial |
| Himawari - Pebble in the Sky Portable | JP | 2010-04-22 |
Kadokawa Games | Commercial |
| Harvest Moon - Hero of Leaf Valley | US | 2010-04-26 |
Natsume | Commercial |
| Hagane no Renkinjutsushi - Yakusoku no Hi e | JP | 2010-05-20 |
Bandai Namco Games | Commercial |
| Hatsune Miku - Project Diva - Dreamy Theater | JP | 2010-06 |
| Add-on |
| Hexyz Force | JP | 2010-06 |
Atlus | Commercial |
| Hexyz Force | US | 2010-06-02 |
Atlus | Commercial |
| Hisshou Pachinko Pachi-Slot Kouryaku Series Portable Vol. 1 - Shin Seiki Evangelion - Tamashii no Kiseki | JP | 2010-06-03 |
D3 Publisher | Commercial |
| Hot Shots Tennis - Get a Grip | US | 2010-06-29 |
SCEI | Commercial |
| Hanayaka Nari, Wa ga Ichizoku | JP | 2010-07 |
| Commercial |
| Hello Kitty to Issho! Block Crash 123!! | JP | 2010-07-15 |
Dorart | Commercial |
| Hatsune Miku - Project Diva 2nd | JP | 2010-07-29 |
Sega | Commercial |
| Hatsune Miku - Project Diva 2nd | JP | 2010-07-29 |
Sega | Add-on |
| Hakuouki Portable | JP | 2010-08 |
Idea Factory | Commercial |
| Hanakisou | JP | 2010-08-12 |
Prototype | Commercial |
| Hiiro no Kakera - Shin Tamayori-hime Denshou Portable | JP | 2010-09-30 |
Idea Factory | Commercial |
| Hisshou Pachinko Pachi-Slot Kouryaku Series Portable Vol. 2 - CR Evangelion - Evangelical of the Beginnings | JP | 2010-11-18 |
D3 Publisher | Commercial |
| Harukanaru Toki no Naka de 4 - Aizouban | JP | 2010-12-22 |
Koei Tecmo Games | Commercial |