| Aerodive | JP | 2001-01 |
Banpresto | Commercial |
| Aqua GT | EU | 2001-01-26 |
Take 2 Interactive | Commercial |
| Arcade Party Pak | AU | 2001-02-23 |
Midway Home Entertainment | Commercial |
| Arcade Party Pak | EU | 2001-02-23 |
Midway Home Entertainment | Commercial |
| Air Management '96 | JP | 2001-03 |
Koei | Commercial |
| Army Men - Lock 'n' Load | EU | 2001-03-30 |
The 3DO Company | Commercial |
| Army Men - World War - Final Front | US | 2001-03-30 |
The 3DO Company | Commercial |
| Anastasia | EU | 2001-04-12 |
Midas Interactive | Commercial |
| Army Men - Green Rogue | US | 2001-04-13 |
The 3DO Company | Commercial |
| Army Men - Omega Soldier | EU | 2001-04-27 |
The 3DO Company | Commercial |
| Alone in the Dark - The New Nightmare | AU | 2001-05-18 |
Infogrames | Prototype |
| Alone in the Dark - The New Nightmare | DE | 2001-06 |
Infogrames | Commercial |
| Alone in the Dark - The New Nightmare | ES | 2001-06 |
Infogrames | Commercial |
| Alone in the Dark - The New Nightmare | EU | 2001-06 |
Infogrames | Commercial |
| Alone in the Dark - The New Nightmare | FR | 2001-06 |
Infogrames | Commercial |
| Alone in the Dark - The New Nightmare | IT | 2001-06 |
Infogrames | Commercial |
| Afraid Gear Another | JP | 2001-06-14 |
Asmik Ace Entertainment | Commercial |
| Akagawa Jirou - Yasoukyoku 2 | JP | 2001-06-14 |
Victor Interactive Software | Commercial |
| Alone in the Dark - The New Nightmare | US | 2001-06-18 |
Infogrames | Commercial |
| Asterix - Mega Madness | EU | 2001-06-29 |
Infogrames | Commercial |
| Asterix - Mega Madness | EU | 2001-06-29 |
Infogrames | Demo |
| Apocalypse | JP | 2001-08 |
Success | Commercial |
| Assault Suits Valken 2 | JP | 2001-08 |
Cyclone (Four Winds) | Commercial |
| Autobahn Raser II | DE | 2001-09 |
Davilex | Commercial |
| Aztec - The Curse in the Heart of the City of Gold | EU | 2001-10 |
Cryo Interactive | Commercial |
| Adibou et l'Ombre Verte | FR | 2001-10-02 |
Vivendi Universal Games | Commercial |
| Action Man - Destruction X | EU | 2001-11 |
The 3DO Company | Commercial |
| Army Men - World War - Team Assault | US | 2001-11 |
The 3DO Company | Commercial |
| Atari Anniversary Edition Redux | US | 2001-11-26 |
Infogrames | Commercial |
| Army Men - Team Assault | EU | 2001-11-30 |
The 3DO Company | Commercial |
| Action Bass | JP | 2001-12 |
Syscom Entertainment | Commercial |