| S.C.I. - Special Criminal Investigation | JP | 1991-01-25 |
Taito | Commercial |
| Sadakichi Seven - Hideyoshi no Ougon | JP | 1988-11 |
Hudson Soft | Commercial |
| Saigo no Nindou - Ninja Spirit | JP | 1990-07 |
Irem | Commercial |
| Salamander | JP | 1991-12-06 |
Konami | Commercial |
| Salamander | WORLD | 1991-12-06 |
Konami | Commercial |
| Samurai-Ghost | US | 1992-04 |
Namco | Commercial |
| Sangokushi - Eiketsu Tenka ni Nozomu | JP | 1991-03-29 |
Naxat Soft | Commercial |
| Sangokushi III | JP | 1993-10-01 |
Koei | Commercial |
| Santatlantean | WORLD | 2014-12 |
Aetherbyte | Unlicensed |
| Seirei Senshi Spriggan | JP | 1991-07-12 |
Naxat Soft | Commercial |
| Seiryuu Densetsu - Monbit | JP | 1991-08-30 |
Hudson Soft | Commercial |
| Seisenshi Denshou - Jantaku no Kishi | JP | 1994-08-01 |
Nichibutsu | Commercial |
| Seiya Monogatari - Anearth Fantasy Stories | JP | 1995-12-22 |
Hudson Soft | Commercial |
| Seiya Monogatari - Anearth Fantasy Stories | JP | 1995-12-22 |
Hudson Soft | Demo |
| Sekigahara | JP | 1990-09-14 |
Tonkin House | Commercial |
| Sengoku Kantou Sangokushi | JP | 1991-06-28 |
Intec | Commercial |
| Sengoku Mahjong | JP | 1988-07-08 |
Hudson Soft | Commercial |
| Sexy Idol Mahjong | JP | 1993-12-24 |
Nichibutsu | Commercial |
| Sexy Idol Mahjong - Fashion Monogatari | JP | 1994-09-16 |
Nichibutsu | Commercial |
| Sexy Idol Mahjong - Yakyuuken no Uta | JP | 1995-01-31 |
Nichibutsu | Commercial |
| Shadow of the Beast | US | 1992-03 |
Psygnosis | Commercial |
| Shadow of the Beast - Mashou no Okite | JP | 1992-03-27 |
Victor Entertainment | Commercial |
| Shanghai | JP | 1987-10-30 |
Hudson Soft | Commercial |
| Shanghai II | JP | 1990-04-13 |
Hudson Soft | Commercial |
| Shape Shifter | US | 1992-10 |
ICOM Simulations | Commercial |
| Sherlock Holmes - Consulting Detective | JP | 1991-07-26 |
Victor Entertainment | Commercial |
| Sherlock Holmes - Consulting Detective | US | 1991-06 |
Sleuth Publications | Commercial |
| Sherlock Holmes - Consulting Detective - Vol. II | JP | 1993-05-28 |
Victor Entertainment | Commercial |
| Sherlock Holmes - Consulting Detective - Vol. II | US | 1993-06 |
Sleuth Publications | Commercial |
| Shiawase Usagi - Nureta Bishoujo - Hajimete Nanoni | JP | 1995 |
Office Asia Kenkyūsho | Unlicensed |
| Shiawase Usagi II - Toraware Usagi Sailor Z | JP | 1995 |
| Unlicensed |
| Shin Megami Tensei | JP | 1993-12-25 |
Atlus | Commercial |
| Shin Nihon Pro Wrestling - '94 Battlefield in Tokyo Dome | JP | 1994-11-25 |
Fujicom | Commercial |
| Shin Onryou Senki | JP | 1995-09-22 |
Fujicom | Commercial |
| Shinobi | JP | 1989-12-08 |
Sega | Commercial |
| Shinsetsu Shiawase Usagi | JP | 1995-09-30 |
B-Project | Unlicensed |
| Shinsetsu Shiawase Usagi 2 - Kairaku e no Invitation | JP | 1996-02-25 |
Rabbit Soft Kenkyūsho | Unlicensed |
| Shinsetsu Shiawase Usagi f - Yuujou yorimo Aiyoku | JP | 1997-10 |
Rabbit Soft Kenkyūsho | Unlicensed |
| Shiryou Sensen - War of the Dead | JP | 1989-03 |
Victor Entertainment | Commercial |
| Shockman | US | 1992-12 |
NCS | Commercial |
| Shougi Database Kiyuu | JP | 1995-10-27 |
SETA | Commercial |
| Shougi Shodan Icchokusen | JP | 1990-08 |
Home Data | Commercial |
| Shougi Shoshinsha Muyou | JP | 1991-11 |
Home Data | Commercial |
| SideArms | US | 1989-07 |
Radiance Software | Commercial |
| Silent Debuggers | JP | 1991-03-29 |
NEC | Commercial |
| Silent Debuggers | US | 1991-10 |
NEC | Commercial |
| SimEarth - The Living Planet | JP | 1993-01-14 |
Hudson Soft | Commercial |
| SimEarth - The Living Planet | US | 1993-01 |
Maxis | Commercial |
| Sindibad - Chitei no Daimakyuu | JP | 1990-06 |
IGS | Commercial |
| Sinistron | US | 1991-01 |
NEC | Commercial |
| Skweek | JP | 1991-08-02 |
Victor Entertainment | Commercial |
| Slot Gambler | JP | 1995-04-28 |
Nichibutsu | Commercial |
| Snatcher CD-ROMantic | JP | 1992-10-23 |
Konami | Commercial |
| Snatcher CD-ROMantic - Pilot Disk | JP | 1992-08-07 |
Konami | Commercial |
| Sol Bianca | JP | 1990-06-29 |
NCS | Commercial |
| Sol Moonarge | JP | 1994-01-07 |
Irem | Commercial |
| Soldier Blade | EU | 1992-07-10 |
Hudson Soft | Commercial |
| Soldier Blade | JP | 1992-07-10 |
Hudson Soft | Commercial |
| Soldier Blade | US | 1992-09 |
Hudson Soft | Commercial |
| Soldier Blade - Special Version | JP | 1992-07-10 |
Hudson Soft | Commercial |
| Solid Force | JP | 1995-03-17 |
NEC Home Electronics | Commercial |
| Somer Assault | US | 1992-12 |
Atlus | Commercial |
| Son Son II | JP | 1989-01-27 |
Capcom | Commercial |
| Sonic Spike - World Championship Beach Volleyball | US | 1990-07 |
IGS | Commercial |
| Sorcerian | JP | 1992-07-17 |
Victor Entertainment | Commercial |
| Sotsugyou - Graduation | JP | 1993-07-30 |
NEC Avenue | Commercial |
| Sotsugyou II - Neo Generation | JP | 1994-12-23 |
Riverhill Soft | Commercial |
| Sotsugyou Shashin - Miki | JP | 1994-10-28 |
Coconuts Japan | Commercial |
| Soukoban World | JP | 1990-03 |
Media Rings | Commercial |
| Space Adventure Cobra - Kokuryuuou no Densetsu | JP | 1989-03-31 |
Hudson Soft | Commercial |
| Space Adventure Cobra II - Densetsu no Otoko | JP | 1991-06-07 |
Hudson Soft | Commercial |
| Space Harrier | JP | 1988-12-09 |
NEC Avenue | Commercial |
| Space Harrier | US | 1990-02 |
NEC Avenue | Commercial |
| Space Invaders - Fukkatsu no Hi | JP | 1990-03-02 |
Taito | Commercial |
| Space Invaders - The Original Game | JP | 1995-07-28 |
NEC Avenue | Commercial |
| Spin Pair | JP | 1990-12-14 |
Media Rings | Commercial |
| Spiral Wave | JP | 1991-12-13 |
Media Rings | Commercial |
| Splash Lake | US | 1992-08 |
NEC Avenue | Commercial |
| Splash Lake - Ostrich Daibouken | JP | 1991-06-28 |
NEC Avenue | Commercial |
| Splatterhouse | JP | 1990-04-03 |
NEC | Commercial |
| Splatterhouse | US | 1990-08 |
NEC | Commercial |
| Spriggan Mark 2 - Re Terraform Project | JP | 1992-05-01 |
Naxat Soft | Commercial |
| Star Breaker | JP | 1994-02-10 |
Rayforce | Commercial |
| Star Mobile | JP | 1992-10-02 |
Naxat Soft | Commercial |
| Star Parodier | JP | 1992-04-24 |
Hudson Soft | Commercial |
| Startling Odyssey | JP | 1993-10-22 |
Rayforce | Commercial |
| Startling Odyssey II - Maryuu Sensou | JP | 1994-10-21 |
Rayforce | Commercial |
| Startling Odyssey II - Maryuu Sensou | JP | 1994-10 |
Rayforce | Demo |
| Steam-Heart's | JP | 1996-03-22 |
TGL | Commercial |
| Stratego | JP | 1992-07-24 |
Victor Interactive Software | Commercial |
| Street Fighter II' - Champion Edition | JP | 1993-06-12 |
NEC | Commercial |
| Strider Hiryuu | JP | 1994-09-22 |
NEC Avenue | Commercial |
| Strife Sisters | WORLD | 2023-12 |
Laconic Software | Unlicensed |
| Strip Fighter II | JP | 1994-03 |
Games Express | Unlicensed |
| Sugoroku, The '92 - Nari Tore - Nariagari Trendy | JP | 1991-12-20 |
Nihon Telenet | Commercial |
| Summer Carnival '92 - Alzadick | JP | 1992-07-17 |
Naxat Soft | Commercial |
| Summer Carnival '93 - NEXZR Special | JP | 1993-07-23 |
Naxat Soft | Commercial |
| Super Air Zonk - Rockabilly-Paradise | US | 1993-07 |
Hudson Soft | Commercial |
| Super Albatross | JP | 1989-09-14 |
Nihon Telenet | Commercial |
| Super CD-ROM^2 Taiken Soft Shuu | JP | 1991-12 |
Hudson Soft | Commercial |