| Silly Bandz | US | 2010 |
Zoo Games | Commercial |
| Solatorobo - Red the Hunter | US | 2010 |
Xseed Games | Commercial |
| Solitaire Overload Plus | US | 2010 |
Telegames | Commercial |
| Sports Collection | US | 2010 |
Ubisoft | Commercial |
| Samantha Swift and the Hidden Roses of Athena | DE | 2010-01 |
Easy Interactive | Commercial |
| Samantha Swift and the Hidden Roses of Athena | US | 2010-01 |
Rondomedia | Commercial |
| Shin Sengoku Tenka Touitsu - Gunyuu-tachi no Souran | JP | 2010-01 |
SystemSoft | Commercial |
| Shougi World Champion - Gekisashi DS | JP | 2010-01 |
Mycom | Commercial |
| Sangokushi DS 3 | JP | 2010-02 |
| Commercial |
| Shounen Kininden Tsumuji | JP | 2010-02 |
Electronic Arts | Commercial |
| Sonic & SEGA All-Stars Racing | EU | 2010-02 |
Sega | Commercial |
| Sonic & SEGA All-Stars Racing | US | 2010-02 |
Sega | Commercial |
| Sakusaku Jinkou Kokyuu Care Training DS | JP | 2010-03 |
| Commercial |
| Scene It Twilight | EU | 2010-03 |
Konami | Commercial |
| Scene It Twilight | US | 2010-03 |
Konami | Commercial |
| Seitokai no Ichizon - DS Suru Seitokai | JP | 2010-03 |
Kadokawa Shoten | Commercial |
| Sengoku Spirits - Gunshi Den | JP | 2010-03 |
Tasuke | Commercial |
| Sengoku Spirits - Moushou Den | JP | 2010-03 |
Tasuke | Commercial |
| Sengoku Spirits - Shukun Den | JP | 2010-03 |
Tasuke | Commercial |
| So Blonde - Back to the Island | EU | 2010-03 |
DTP Entertainment | Commercial |
| Sonic Classic Collection | EU | 2010-03 |
Sega | Commercial |
| Sonic Classic Collection | US | 2010-03 |
Sega | Commercial |
| Sonny with a Chance | US | 2010-03 |
Disney Interactive Studios | Commercial |
| SpongeBob's Boating Bash | EU | 2010-03 |
THQ | Commercial |
| SpongeBob's Boating Bash | US | 2010-03 |
THQ | Prototype |
| Steve Soresi no Business Eikaiwa Pera Pera DS Training | JP | 2010-03 |
IE Institute | Commercial |
| Steve Soresi no Eikaiwa Pera Pera DS Training | JP | 2010-03 |
IE Institute | Commercial |
| Sea Park Tycoon | US | 2010-04 |
Destineer | Commercial |
| Sekaiju no Meikyuu III - Seikai no Raihousha | JP | 2010-04 |
Atlus | Commercial |
| Shepherd's Crossing 2 DS | US | 2010-04 |
Graffiti Entertainment | Commercial |
| Spore - Kimi ga Tsukuru Hero | JP | 2010-04 |
Electronic Arts | Commercial |
| Saka Tsuku DS - World Challenge 2010 | JP | 2010-05 |
Sega | Commercial |
| Samantha Swift and the Hidden Roses of Athena | EU | 2010-05 |
Easy Interactive | Commercial |
| Sekai no Hate made ItteQ! - Chinjuu Hunter Imoto no Daibouken | JP | 2010-05 |
Kamui | Commercial |
| Sports Island DS | EU | 2010-05 |
Hudson Entertainment | Commercial |
| Super Robot Taisen OG Saga - Masou Kishin - The Lord of Elemental | JP | 2010-05 |
Banpresto | Commercial |
| Satisfashion - Rock the Runway | US | 2010-06 |
Destineer | Commercial |
| Sherlock Holmes DS and the Mystery of Osborne House | EU | 2010-06 |
THQ | Commercial |
| Shrek - Forever After | EU | 2010-06 |
Activision | Commercial |
| Shrek - Forever After | US | 2010-06 |
Activison | Commercial |
| Suki Desu Suzuki-kun!! - 4-nin no Suzuki-kun | JP | 2010-07 |
Idea Factory | Commercial |
| Secret Flirts - Make Everyone Fall For You! | EU | 2010-08 |
Nobilis Group | Commercial |
| Shrek - E Vissero Felici e Contenti | IT | 2010-08 |
Activision | Commercial |
| SpongeBob's Boating Bash | US | 2010-08 |
THQ | Commercial |
| Scooby-Doo! and the Spooky Swamp | US | 2010-09 |
Warner Bros. Interactive Entertainment | Commercial |
| Scripps Spelling Bee | US | 2010-09 |
THQ | Commercial |
| Spider-Man - Shattered Dimensions | US | 2010-09 |
Activision | Commercial |
| Smart Girl's Playhouse Party | US | 2010-10 |
UFO Interactive Games | Commercial |
| Sports Collection | EU | 2010-10 |
Ubisoft | Commercial |
| Star Wars - The Force Unleashed II | EU | 2010-10 |
LucasArts | Commercial |
| Star Wars - The Force Unleashed II | US | 2010-10 |
LucasArts | Commercial |
| Strike Witches 2 - Iyasu, Naosu, Punipuni Suru | JP | 2010-10 |
Kadokawa Shoten | Commercial |
| Sumeun Sojireul Kkaeuneun - Geurimgyosil | KR | 2010-10 |
Nintendo | Commercial |
| Super Scribblenauts | EU | 2010-10 |
Konami | Commercial |
| Super Scribblenauts | US | 2010-10 |
Konami | Commercial |
| Shawn Johnson Gymnastics | US | 2010-11 |
Zoo Games | Commercial |
| Sonic Colors | JP | 2010-11 |
Sega | Commercial |
| Sonic Colors | US | 2010-11 |
Sega | Commercial |
| Sonic Colors | WORLD | 2010-11 |
Sega | Commercial |
| Sonic Colours | EU | 2010-11 |
Sega | Commercial |
| Style Lab - Fashion Design | US | 2010-11 |
Ubisoft | Commercial |
| Super Kaseki Horider | JP | 2010-11 |
Nintendo | Commercial |
| Super Robot Taisen L | JP | 2010-11 |
Bandai Namco Games | Commercial |
| SD Gundam Sangoku Den - Brave Battle Warriors - Shin Militia Taisen | JP | 2010-12 |
Namco Bandai Games | Commercial |
| Shoukou Shindan Training DS | JP | 2010-12 |
| Commercial |