| Harvest Moon DS - The Tale of Two Towns | US | 2010 |
Marvelous Interactive | Commercial |
| Home Designer - Perfekt Gestylte Zimmer | DE | 2010 |
TREVA Entertainment | Commercial |
| Heracles no Eikou - Tamashii no Shoumei | JP | 2010-01 |
Nintendo | Commercial |
| Hello Kitty - Birthday Adventures | US | 2010-02 |
Zoo Games | Commercial |
| Higurashi no Naku Koro ni Kizuna IV - Daiyonkan - Kizuna | JP | 2010-02 |
Alchemist | Commercial |
| Hugo - Magic in the Trollwoods | EU | 2010-02 |
KREA Medie | Commercial |
| Hakuouki - Zuisouroku DS | JP | 2010-03 |
Idea Factory | Commercial |
| Hakuouki DS | JP | 2010-03 |
Idea Factory | Commercial |
| Hidden Mysteries - Buckingham Palace - Secrets of Kings and Queens | US | 2010-03 |
GameMill Entertainment | Commercial |
| Horrid Henry - Missions of Mischief | EU | 2010-03 |
SouthPeak Games | Commercial |
| How to Train Your Dragon | US | 2010-03 |
Activision | Commercial |
| Happily Ever After - Volume 1 | US | 2010-04 |
Storm City Games | Commercial |
| Happily Ever After - Volume 2 | US | 2010-04 |
Storm City Games | Commercial |
| Hudson x GReeeeN - Live! DeeeeS! | JP | 2010-04 |
Hudson Soft | Commercial |
| Hisshou Pachinko Pachi-Slot Kouryaku Series DS Vol. 5 - Shinseiki Evangelion - Tamashii no Kiseki | JP | 2010-06 |
D3 Publisher | Commercial |
| Hidden Objects - Mystery Stories | US | 2010-07 |
Knowledge Adventure | Commercial |
| HeartCatch PreCure! - Oshare Collection | JP | 2010-08 |
Namco Bandai Games | Commercial |
| Hidden Mysteries - Vampire Secrets | US | 2010-08 |
GameMill Publishing | Commercial |
| Horse Life - Adventures | US | 2010-09 |
Valcon Games | Commercial |
| Horse Life 3 | EU | 2010-09 |
Deep Silver | Commercial |
| Honda ATV Fever | US | 2010-10 |
CokeM Interactive | Commercial |
| Harry Potter and the Deathly Hallows - Part 1 | EU | 2010-11 |
Electronic Arts | Commercial |
| Harry Potter and the Deathly Hallows - Part 1 | US | 2010-11 |
Electronic Arts | Commercial |
| Harvest Moon - Frantic Farming | EU | 2010-11 |
Rising Star Games | Commercial |
| Heathcliff! - Frantic Foto | US | 2010-11 |
Storm City Games | Commercial |
| Hidden Mysteries - Salem Secrets - Witch Trials of 1692 | US | 2010-11 |
GameMill Publishing | Commercial |
| Hot Wheels - Track Attack | BR | 2010-11 |
THQ | Commercial |
| Hot Wheels - Track Attack | EU | 2010-11 |
THQ | Commercial |
| Hot Wheels - Track Attack | US | 2010-11 |
THQ | Commercial |
| Hugo - Kampen om Krystalkortet | DK | 2010-11 |
KREA Medie | Commercial |
| Hugo - Trollakademin 2 - Jakten pa Kristallkartan | EU | 2010-11 |
KREA Medie | Commercial |
| Harvest Moon DS - Sunshine Islands | EU | 2010-12 |
Natsume | Commercial |
| Harvest Moon DS - Sunshine Islands | US | 2010-12 |
Marvelous Entertainment | Commercial |
| House M.D. - The Official Game | EU | 2010-12 |
Mindscape | Commercial |