| Actionloop | EU | 2006-01 |
Nintendo | Commercial |
| Alex Rider - Stormbreaker | EU | 2006-01 |
THQ | Commercial |
| Age of Empires - The Age of Kings | US | 2006-02 |
Majesco Entertainment | Commercial |
| Animal Crossing - Wild World | EU | 2006-03 |
Nintendo | Commercial |
| Angelique Duet | JP | 2006-04 |
Koei | Commercial |
| Actionloop - Multiplayer | EU | 2006-06 |
Nintendo | Commercial |
| Atama o Kitaete Asobu Taisen Yajirushi Puzzle - Puppynu Vector One | JP | 2006-06 |
Megacyber | Commercial |
| Alex Rider - Stormbreaker | UK | 2006-07 |
THQ | Commercial |
| Atsumare! Power Pro Kun no DS Koushien | JP | 2006-08 |
Konami | Commercial |
| Alex Rider - Stormbreaker | US | 2006-09 |
THQ | Commercial |
| American Dragon - Jake Long | EU | 2006-10 |
Disney Interactive Studios | Commercial |
| American Dragon - Jake Long - Attack of the Dark Dragon | US | 2006-10 |
Disney Interactive Studios | Prototype |
| American Dragon - Jake Long - Attack of the Dark Dragon | US | 2006-10 |
Disney Interactive Studios | Commercial |
| Avatar - The Last Airbender | US | 2006-10 |
THQ | Commercial |
| Avatar - The Last Airbender | US | 2006-10 |
THQ | Prototype |
| Age of Empires - The Age of Kings | EU | 2006-11 |
Majesco Entertainment | Commercial |
| Akumajou Dracula - Gallery of Labyrinth | JP | 2006-11 |
Konami | Commercial |
| Asphalt - Urban GT 2 | EU | 2006-11 |
Ubisoft | Commercial |
| Asphalt - Urban GT 2 | US | 2006-11 |
Ubisoft | Commercial |
| Asterix & Obelix XXL 2 - Mission Wifix | EU | 2006-11 |
Atari Europe | Commercial |
| Akko ni Omakase! - Brain Shock | JP | 2006-12 |
Taito | Commercial |
| Anpanman to Asobo - Aiueo Kyoushitsu | JP | 2006-12 |
Agatsuma Entertainment | Commercial |