| Daffy Duck in Hollywood | BR | 1994 |
Sega Enterprises | Commercial |
| Daffy Duck in Hollywood | EU | 1994 |
Sega Enterprises | Commercial |
| Damojie Cun - Ghouls'n Ghosto | TW | |
| Unlicensed |
| Dangerous Demolition | WORLD | 2020 |
2Minds | Unlicensed |
| David Robinson's Supreme Court | US | 1991 |
Sega | Demo |
| Deep Duck Trouble Starring Donald Duck | BR | 1994 |
Sega | Commercial |
| Deep Duck Trouble Starring Donald Duck | EU | 1994-01 |
Sega | Commercial |
| Deep Duck Trouble Starring Donald Duck | US | 1993-12 |
Sega | Commercial |
| Defenders of Oasis | EU | 1992-09 |
Sega of America | Commercial |
| Defenders of Oasis | EU | 1992-09 |
Sega of America | Prototype |
| Defenders of Oasis | US | 1992-12 |
Sega of America | Commercial |
| Defenders of Oasis | US | 1992-12 |
Sega of America | Prototype |
| Desert Speedtrap Starring Road Runner and Wile E. Coyote | BR | 1993-11 |
Sega of America | Commercial |
| Desert Speedtrap Starring Road Runner and Wile E. Coyote | EU | 1994 |
Sega of America | Commercial |
| Desert Speedtrap Starring Road Runner and Wile E. Coyote | US | 1993-12 |
Sega of America | Commercial |
| Desert Strike | EU | 1993 |
Domark | Commercial |
| Desert Strike - Return to the Gulf | US | 1994 |
Domark | Commercial |
| Devilish | BR | 1992 |
Sega | Commercial |
| Devilish | EU | 1991-03 |
Sega | Commercial |
| Devilish | JP | 1991-03-29 |
Sega | Commercial |
| Devilish | US | 1991-11 |
Sega | Commercial |
| Dinobasher Starring Bignose the Caveman | EU | 1993 |
Codemasters | Prototype |
| Donald Duck no 4-Tsu no Hihou | JP | 1993-12 |
Sega | Commercial |
| Donald Duck no Lucky Dime | JP | 1991-12 |
Sega of America | Commercial |
| Donald no Magical World | JP | 1994-03-04 |
Sega Enterprises | Commercial |
| Donkey.GG | WORLD | 2021-02 |
raphnet | Prototype |
| Doraemon - Noranosuke no Yabou | JP | 1993-04 |
Sega Enterprises | Commercial |
| Doraemon - Waku Waku Pocket Paradise | JP | 1996-04 |
Sega Enterprises | Commercial |
| Double Dragon | EU | 1993-03 |
Virgin | Commercial |
| Double Dragon | EU | 1993-03 |
Virgin | Prototype |
| Double Dragon | US | 1993-03 |
Virgin | Commercial |
| Double Dragon | US | 1993-03 |
Virgin | Prototype |
| Dr. Robotnik's Mean Bean Machine | EU | 1994-01 |
Sega of America | Commercial |
| Dr. Robotnik's Mean Bean Machine | US | 1993-12 |
Sega of America | Commercial |
| Dracula no Shiro | JP | 2021-08 |
| Unlicensed |
| Dragon - The Bruce Lee Story | EU | 1994-09 |
Virgin Interactive | Commercial |
| Dragon - The Bruce Lee Story | EU | 1994-09 |
Virgin Interactive | Prototype |
| Dragon - The Bruce Lee Story | US | 1994-09 |
Virgin Interactive | Commercial |
| Dragon Crystal | EU | 1991 |
Sega of America | Commercial |
| Dragon Crystal | US | 1991 |
Sega of America | Commercial |
| Dragon Crystal - Tsurani no Meikyuu | JP | 1990-12 |
Sega of America | Commercial |
| Dunk Kids | JP | 1994-09-16 |
Sega Enterprises | Commercial |
| Dynamite Headdy | EU | 1994-10 |
Sega Enterprises | Commercial |
| Dynamite Headdy | EU | 1994-10 |
Sega Enterprises | Prototype |
| Dynamite Headdy | JP | 1994-08-05 |
Sega Enterprises | Commercial |
| Dynamite Headdy | JP | 1994-08-05 |
Sega Enterprises | Prototype |
| Dynamite Headdy | US | 1994-09 |
Sega Enterprises | Commercial |
| Dynamite Headdy | US | 1994-09 |
Sega Enterprises | Prototype |