| Sagaia | US | 1991 |
Taito | Commercial |
| Shadow Dancer - The Secret of Shinobi | EU | 1991 |
Sega | Commercial |
| Shadow Dancer - The Secret of Shinobi | WORLD | 1991 |
Sega | Commercial |
| Shadow Dancer - The Secret of Shinobi | WORLD | 1991 |
Sega | Prototype |
| Sonic Eraser | JP | 1991 |
Sega | Commercial |
| Space Invaders '91 | US | 1991 |
Taito | Commercial |
| Star Mobile | EU | 1991 |
M.N.M. Software | Commercial |
| Star Mobile | JP | 1991 |
M.N.M. Software | Commercial |
| Star Mobile | JP | 1991 |
M.N.M. Software | Prototype |
| Star Mobile | US | 1991 |
M.N.M. Software | Commercial |
| Super Hydlide | EU | 1991 |
Asmik | Commercial |
| Super Volley Ball | JP | 1991-02 |
Video System | Commercial |
| Super Volley Ball | US | 1991-02 |
| Unlicensed |
| Super Volleyball | US | 1991-02 |
Video System | Commercial |
| Shengzhan Fengyun | CN | 1991-03 |
| Unlicensed |
| Shining and the Darkness | JP | 1991-03 |
Sega | Commercial |
| Shining in the Darkness | BR | 1991-03 |
Sega | Commercial |
| Super Real Basketball | EU | 1991-03 |
Sega | Commercial |
| Super Airwolf | JP | 1991-03-29 |
Kyugo Boueki | Commercial |
| San Guo Zhi Lie Zhuan - Luan Shi Qun Ying | AS | 1991-04 |
Koei | Commercial |
| Sangokushi Retsuden - Ransei no Eiyuutachi | JP | 1991-04 |
Sega | Commercial |
| Shikinjou | JP | 1991-04 |
Sunsoft | Commercial |
| Sonic The Hedgehog | EU | 1991-06 |
Sega | Commercial |
| Sonic The Hedgehog | EU | 1991-06 |
Sega | Prototype |
| Sonic The Hedgehog | US | 1991-06 |
Sega | Commercial |
| Sonic The Hedgehog | US | 1991-06 |
Sega | Prototype |
| Sonic The Hedgehog | WORLD | 1991-06 |
Sega | Commercial |
| Star Control | US | 1991-06 |
Ballistic | Unlicensed |
| Star Odyssey | US | 1991-06 |
Hot-B | Prototype |
| Street Smart | US | 1991-06 |
Treco | Commercial |
| Street Smart | US | 1991-06 |
Treco | Prototype |
| Sonic The Hedgehog | KR | 1991-06-23 |
Sega | Commercial |
| Saint Sword | JP | 1991-06-28 |
Taito | Commercial |
| Star Control | EU | 1991-07 |
Ballistic | Unlicensed |
| Street Smart | JP | 1991-07-19 |
Treco | Commercial |
| Street Smart | JP | 1991-07-19 |
Treco | Prototype |
| Sonic The Hedgehog | JP | 1991-07-26 |
Sega | Commercial |
| Streets of Rage | WORLD | 1991-08 |
Sega | Commercial |
| Saint Sword | US | 1991-10 |
Taito | Commercial |
| Shining in the Darkness | US | 1991-10 |
Sega | Commercial |
| Shougi no Hoshi | JP | 1991-10 |
Home Data | Commercial |
| Starflight | US | 1991-10-07 |
Binary Systems | Commercial |
| Starflight | EU | 1991-10-09 |
Binary Systems | Commercial |
| Sword of Sodan | JP | 1991-10-11 |
Electronic Arts | Commercial |
| Spider-Man vs. The Kingpin | WORLD | 1991-10-18 |
Sega | Commercial |
| Shadow of the Beast | CN | 1991-11 |
| Unlicensed |
| Shadow of the Beast | US | 1991-11 |
Electronic Arts | Commercial |
| Shining in the Darkness | EU | 1991-11-11 |
Sega | Commercial |
| Sangokushi II | JP | 1991-12 |
Koei | Commercial |
| Shadow of the Beast | EU | 1991-12 |
Electronic Arts | Commercial |
| Shikong Yibian | CN | 1991-12 |
| Unlicensed |
| Speedball 2 - Brutal Deluxe | US | 1991-12 |
The Bitmap Brothers | Commercial |
| Speedball 2 - Brutal Deluxe | US | 1991-12 |
The Bitmap Brothers | Prototype |
| Speedball 2 - Brutal Deluxe | WORLD | 1991-12 |
Arena | Commercial |
| Slaughter Sport | US | 1991-12-20 |
RazorSoft | Commercial |