| Speedball 2 - Brutal Deluxe | US | 1991-12 |
The Bitmap Brothers | Prototype |
| Speedball 2 - Brutal Deluxe | WORLD | 1991-12 |
Arena | Commercial |
| Spider-Man | EU | 1995 |
Acclaim Entertainment | Commercial |
| Spider-Man | EU | 1995 |
Acclaim Entertainment | Prototype |
| Spider-Man | US | 1995 |
Acclaim Entertainment | Commercial |
| Spider-Man | US | 1995 |
Acclaim Entertainment | Prototype |
| Spider-Man - Venom - Maximum Carnage | WORLD | 1994-09-16 |
Acclaim Entertainment | Commercial |
| Spider-Man - X-Men - Arcade's Revenge | EU | 1993-11 |
Acclaim Entertainment | Commercial |
| Spider-Man - X-Men - Arcade's Revenge | US | 1994 |
Acclaim Entertainment | Commercial |
| Spider-Man - X-Men - Arcade's Revenge | WORLD | 1994 |
Flying Edge | Commercial |
| Spider-Man vs. The Kingpin | WORLD | 1991-10-18 |
Sega | Commercial |
| Spike Hell | WORLD | |
| Unlicensed |
| Spiritual Warfare | US | 1994 |
Wisdom Tree | Unlicensed |
| Spirou | EU | 1995 |
Infogrames | Commercial |
| Spirou | EU | 1995 |
Infogrames | Prototype |
| Splatterhouse 2 | EU | 1992-10-07 |
Namco | Commercial |
| Splatterhouse 2 | US | 1992-07 |
Namco | Commercial |
| Splatterhouse 2 | WORLD | 1992-07 |
Sega | Commercial |
| Splatterhouse 3 | US | 1993-08 |
Namco | Commercial |
| Splatterhouse 3 | WORLD | 1993-03-19 |
Namco | Commercial |
| Splatterhouse Part 2 | JP | 1992-08 |
Namco | Commercial |
| Splatterhouse Part 3 | JP | 1993-03-19 |
Namco | Commercial |
| Splatterhouse Part 3 | KR | 1993-03-19 |
Namco | Commercial |
| Sport Games | BR | 1998-05 |
Tec Toy | Commercial |
| Sports Talk Baseball | US | 1992 |
Sega | Commercial |
| Spot Goes to Hollywood | EU | 1996 |
Acclaim Entertainment | Commercial |
| Spot Goes to Hollywood | US | 1995-11 |
Acclaim Entertainment | Commercial |
| Squirrel King | TW | 1995 |
Gamtec | Unlicensed |
| Star Control | EU | 1991-07 |
Ballistic | Unlicensed |
| Star Control | US | 1991-06 |
Ballistic | Unlicensed |
| Star Cruiser | JP | 1990-12-21 |
Masaya Games | Commercial |
| Star Mobile | EU | 1991 |
M.N.M. Software | Commercial |
| Star Mobile | JP | 1991 |
M.N.M. Software | Commercial |
| Star Mobile | JP | 1991 |
M.N.M. Software | Prototype |
| Star Mobile | US | 1991 |
M.N.M. Software | Commercial |
| Star Odyssey | US | 1991-06 |
Hot-B | Prototype |
| Star Odyssey | US | 2011 |
Hot-B | Commercial |
| Star Trek - Deep Space Nine - Crossroads of Time | EU | 1995-06 |
Playmates Interactive | Commercial |
| Star Trek - Deep Space Nine - Crossroads of Time | US | 1995-06 |
Playmates Interactive | Commercial |
| Star Trek - The Next Generation - Echoes from the Past | US | 1994-03 |
Sega | Commercial |
| Star Trek - The Next Generation - Echoes from the Past | US | 1994-03 |
Sega | Prototype |
| Star Wars | US | 1993 |
Sega | Prototype |
| Starflight | EU | 1991-10-09 |
Binary Systems | Commercial |
| Starflight | US | 1991-10-07 |
Binary Systems | Commercial |
| Stargate | EU | 1995-03-24 |
Acclaim Entertainment | Commercial |
| Stargate | EU | 1995-03-24 |
Acclaim Entertainment | Prototype |
| Stargate | EU | 1995-03-24 |
Acclaim Entertainment | Demo |
| Stargate | US | 1995-03 |
Acclaim Entertainment | Commercial |
| Stargate | US | 1995-03 |
Acclaim Entertainment | Prototype |
| Stargate | US | 1995-03 |
Acclaim Entertainment | Demo |
| Steel Empire | US | 1992-03 |
Hot-B | Commercial |
| Steel Talons | EU | 1993-02 |
Atari | Commercial |
| Steel Talons | EU | 1993-02 |
Atari | Prototype |
| Steel Talons | JP | 1993-06-25 |
Atari | Commercial |
| Steel Talons | KR | 1992 |
Atari | Commercial |
| Steel Talons | US | 1992 |
Atari | Commercial |
| Steel Talons | US | 1992 |
Atari | Prototype |
| Stoat XV | WORLD | 2023-11 |
Safety Stoat Studios | Unlicensed |
| Stone Protectors | JP | 1994 |
Vic Tokai | Commercial |
| Stone Protectors | US | 1994 |
Kemco | Prototype |
| Stone Protectors | WORLD | 1994 |
Vic Tokai | Commercial |
| Stormlord | JP | 1992-03-27 |
Hewson | Commercial |
| Stormlord | US | 1990 |
Hewson | Commercial |
| Street Fighter II' - Champion Edition | EU | 1993 |
Sega | Prototype |
| Street Fighter II' - Champion Edition | US | 1993 |
Sega | Prototype |
| Street Fighter II' - Special Champion Edition | EU | 1993-10-29 |
Sega | Commercial |
| Street Fighter II' - Special Champion Edition | US | 1993-09 |
Sega | Commercial |
| Street Fighter II' Plus - Champion Edition | JP | 1993-09-28 |
Capcom | Commercial |
| Street Fighter II' Plus - Champion Edition | KR | 1993-09-28 |
Capcom | Commercial |
| Street Racer | EU | 1995-04 |
Ubisoft | Commercial |
| Street Racer | EU | 1995-04 |
Ubisoft | Demo |
| Street Smart | JP | 1991-07-19 |
Treco | Commercial |
| Street Smart | JP | 1991-07-19 |
Treco | Prototype |
| Street Smart | US | 1991-06 |
Treco | Commercial |
| Street Smart | US | 1991-06 |
Treco | Prototype |
| Streets of Rage | WORLD | 1991-08 |
Sega | Commercial |
| Streets of Rage 2 | US | 1992-12 |
Sega | Commercial |
| Streets of Rage 3 | AS | 1994-03 |
Sega | Commercial |
| Streets of Rage 3 | EU | 1994-06 |
Sega | Commercial |
| Streets of Rage 3 | EU | 1994-06 |
Sega | Prototype |
| Streets of Rage 3 | US | 1994-03 |
Sega | Commercial |
| Streets of Rage 3 | US | 1994-03 |
Sega | Prototype |
| Streets of Rage II | EU | 1993-01 |
Sega | Commercial |
| Streets of Rage II | JP | 1993-01 |
Sega | Commercial |
| Strider | EU | 1990-09 |
Capcom | Commercial |
| Strider | US | 1990-12 |
Capcom | Commercial |
| Strider Hiryuu | JP | 1990-09-29 |
Capcom | Commercial |
| Strider Hiryuu | KR | 1990-09-29 |
Capcom | Commercial |
| Strider II | EU | 1993-03 |
Capcom | Commercial |
| Striker | EU | 1995-06 |
Sega | Prototype |
| Striker | EU | 1995-06 |
Sega | Commercial |
| Sub-Terrania | AS | 1994-04 |
Scavenger | Commercial |
| Sub-Terrania | AS | 1994-04 |
Scavenger | Prototype |
| Sub-Terrania | EU | 1994-05 |
Scavenger | Commercial |
| Sub-Terrania | US | 1994-03 |
Scavenger | Commercial |
| Sub-Terrania | US | 1994-03 |
Scavenger | Prototype |
| Submarine Attack | WORLD | 2025-08 |
Camden Town Games | Unlicensed |
| Submarine Canyon Bomber vs Marine Aliens | WORLD | 2017 |
Hideki Konishi | Unlicensed |
| Sudoku | WORLD | |
| Unlicensed |
| Sukiya | WORLD | 2021-04 |
Z-team | Prototype |