| SD Valis | JP | 1992-02-14 |
Laser Soft | Commercial |
| SEGA Master System Brawl | WORLD | 2021-06 |
Bonaf | Unlicensed |
| SMB4MD | WORLD | |
| Unlicensed |
| ST II' Turbo | US | 1994 |
Capcom | Prototype |
| Sacred Line Genesis | WORLD | 2013-10 |
WaterMelon | Prototype |
| Sacred Line Genesis | WORLD | 2013-10 |
WaterMelon | Demo |
| Sacred Line II | WORLD | 2022 |
| Unlicensed |
| Sacred Line Zero | WORLD | |
| Prototype |
| Sagaia | US | 1991 |
Taito | Commercial |
| Saint Sword | JP | 1991-06-28 |
Taito | Commercial |
| Saint Sword | US | 1991-10 |
Taito | Commercial |
| Same! Same! Same! | JP | 1990-11 |
Sega | Commercial |
| Same! Same! Same! | JP | 1990-11 |
Sega | Prototype |
| Sampras Tennis 96 | EU | 1995-07-28 |
Codemasters | Commercial |
| Samurai Shodown | EU | 1995-02 |
Saurus | Commercial |
| Samurai Shodown | US | 1994-11 |
Saurus | Commercial |
| Samurai Shodown vs Soul Edge | TW | 1997 |
X Boy | Unlicensed |
| Samurai Spirits | JP | 1994-11 |
Saurus | Commercial |
| San Guo Zhi Lie Zhuan - Luan Shi Qun Ying | AS | 1991-04 |
Koei | Commercial |
| Sangokushi II | JP | 1991-12 |
Koei | Commercial |
| Sangokushi III | JP | 1992-11 |
Koei | Commercial |
| Sangokushi Retsuden - Ransei no Eiyuutachi | JP | 1991-04 |
Sega Enterprises | Commercial |
| Sanguo Yanyi - Huoshao Chibi | TW | |
Gamtec | Unlicensed |
| Sanguozhi V | TW | 1996 |
SKOB | Unlicensed |
| Sanrin San-chan - Spatter | WORLD | 2022-10 |
Sega | Commercial |
| Sansan | JP | 1994-09 |
Sansan | Commercial |
| Satan Claus | WORLD | 2024 |
| Unlicensed |
| Saturday Night Slammasters | EU | 1994 |
Capcom | Commercial |
| Saturday Night Slammasters | US | 1994-12 |
Capcom | Commercial |
| Scooby-Doo Mystery | US | 1995-09 |
Acclaim Entertainment | Commercial |
| Scrabble | EU | 1994 |
Supervision Entertainment | Prototype |
| Scream Mr. Jack | WORLD | 2021-03 |
kakoeimon | Unlicensed |
| Seasaw Space Security Squad | WORLD | 2024-02 |
Safety Stoat Studios | Unlicensed |
| Second Samurai | EU | 1994-11 |
Psygnosis | Commercial |
| Second Samurai | WORLD | 1994-11 |
Psygnosis | Commercial |
| Sega Sports 1 | EU | 1995 |
Sega Enterprises | Commercial |
| Sega Top Five | BR | 1997-11 |
Tec Toy | Commercial |
| SegaSonic Bros | WORLD | 2018 |
Dustin O’Dell | Prototype |
| Segapede | US | 1994 |
Sega | Prototype |
| Sensible Soccer | EU | 1994 |
Renegade Software | Commercial |
| Sensible Soccer | EU | 1994 |
Renegade Software | Prototype |
| Sensible Soccer | WORLD | 1993-12-10 |
Renegade Software | Commercial |
| Sesame Street Counting Cafe | US | 1994 |
Electronic Arts | Commercial |
| Shadow Blasters | US | 1990-08 |
Sage's Creation | Commercial |
| Shadow Dancer | CN | 1990-12 |
| Unlicensed |
| Shadow Dancer - The Secret of Shinobi | EU | 1991 |
Sega of America | Commercial |
| Shadow Dancer - The Secret of Shinobi | US | 1990-12-01 |
Sega of America | Commercial |
| Shadow Dancer - The Secret of Shinobi | WORLD | 1991 |
Sega of America | Commercial |
| Shadow Dancer - The Secret of Shinobi | WORLD | 1991 |
Sega of America | Prototype |
| Shadow of the Beast | CN | 1991-11 |
| Unlicensed |
| Shadow of the Beast | EU | 1991-12 |
Electronic Arts | Commercial |
| Shadow of the Beast | US | 1991-11 |
Electronic Arts | Commercial |
| Shadow of the Beast - Mashou no Okite | JP | 1992-03 |
Electronic Arts | Commercial |
| Shadow of the Beast II | EU | 1992-11 |
Electronic Arts | Commercial |
| Shadow of the Beast II | US | 1992-11 |
Electronic Arts | Commercial |
| Shadowrun | AS | 1994-03 |
Sega | Commercial |
| Shadowrun | US | 1994-03 |
Sega | Commercial |
| Shadowrun | US | 1994-03 |
Sega | Prototype |
| Shadows of the Wind | EU | |
| Prototype |
| Shane Warne Cricket | AU | 1996-05-17 |
Codemasters | Commercial |
| Shanghai II - Dragon's Eye | US | 1994-03 |
Activision | Commercial |
| Shanghai II - Dragon's Eye | US | 1994-03 |
Activision | Prototype |
| Shaolin Carcara | WORLD | 2020 |
Falcon | Unlicensed |
| Shaq-Fu | EU | 1994-10-28 |
Delphine Software International | Commercial |
| Shaq-Fu | US | 1994-10-28 |
Delphine Software International | Commercial |
| Shattering Jaws | WORLD | 2016 |
MoonWatcherMD | Unlicensed |
| Shengzhan Fengyun | CN | 1991-03 |
| Unlicensed |
| Shi no Meikyuu - Labyrinth of Death | JP | 1990-11-21 |
Sega of America | Commercial |
| Shijou Saidai no Soukoban | JP | 1989 |
DreamWorks | Commercial |
| Shikinjou | JP | 1991-04 |
Sunsoft | Commercial |
| Shikong Yibian | CN | 1991-12 |
| Unlicensed |
| Shiliu Zhang Mahjong - Xiangyan Meiren Pian | TW | 1992 |
Sun Green | Unlicensed |
| Shiliu Zhang Mahjong II | TW | |
| Unlicensed |
| Shin Changsegi - Ragnacenty | KR | 1995 |
Atlus | Commercial |
| Shin Souseiki Ragnacenty | JP | 1994-06-17 |
Atlus | Commercial |
| Shin Souseiki Ragnacenty | JP | 1994-06-17 |
Atlus | Prototype |
| Shining Force | EU | 1993-07 |
Sega of America | Commercial |
| Shining Force | US | 1993-05 |
Sega of America | Commercial |
| Shining Force | US | 1993-05 |
Sega of America | Prototype |
| Shining Force - Kamigami no Isan | JP | 1992-03 |
Sega of America | Commercial |
| Shining Force II | EU | 1994-09 |
Sega of America | Commercial |
| Shining Force II | US | 1994-10 |
Sega of America | Commercial |
| Shining Force II | US | 1994-10 |
Sega of America | Prototype |
| Shining Force II - Inishie no Fuuin | JP | 1993-10 |
Sega of America | Commercial |
| Shining and the Darkness | JP | 1991-03 |
Sega of America | Commercial |
| Shining in the Darkness | BR | 1991-03 |
Sega of America | Commercial |
| Shining in the Darkness | EU | 1991-11-11 |
Sega of America | Commercial |
| Shining in the Darkness | US | 1991-10 |
Sega of America | Commercial |
| Shinobi III - Return of the Ninja Master | EU | 1993-07 |
Sega of America | Commercial |
| Shinobi III - Return of the Ninja Master | US | 1993-08 |
Sega of America | Commercial |
| Shinobi III - Return of the Ninja Master | US | 1993-08 |
Sega of America | Prototype |
| Shisan Zhang Mahjong - 98 Mei Shaonu | TW | 1998 |
| Unlicensed |
| Shisan Zhang Mahjong - Zhongguo Meinu Pian | TW | 1993 |
| Unlicensed |
| Shiten Myouou | JP | 1990-08 |
Sage's Creation | Commercial |
| Shougi no Hoshi | JP | 1991-10 |
Home Data | Commercial |
| Shove It! ...The Warehouse Game | US | 1990-04 |
DreamWorks | Commercial |
| Show do Milhao | BR | 2001 |
Tec Toy | Commercial |
| Show do Milhao - Volume 2 | BR | 2002 |
Tec Toy | Commercial |
| Shuihu Fengyun Zhuan | TW | 1996 |
Piko Interactive | Unlicensed |
| Shuihu Zhuan | TW | 1996 |
Chuanpu Technologies | Unlicensed |