| Sonic Adventure 7 | TW | 1999 |
Makon Soft | Unlicensed |
| South Park | US | 1999 |
Crawfish Entertainment | Prototype |
| Shadowgate Classic | EU | 1999-01 |
Kemco | Commercial |
| Shadowgate Classic | US | 1999-01 |
Kemco | Commercial |
| Supreme Snowboarding | EU | 1999-01 |
Infogrames | Commercial |
| Suzuki Alstare Extreme Racing | US | 1999-01 |
Ubisoft | Prototype |
| Speedy Gonzales - Aztec Adventure | EU | 1999-02 |
Epoch | Commercial |
| Speedy Gonzales - Aztec Adventure | JP | 1999-02 |
Epoch | Prototype |
| Speedy Gonzales - Aztec Adventure | US | 1999-02 |
Epoch | Commercial |
| Shougi 2 | JP | 1999-03 |
Pony Canyon | Commercial |
| SD Hiryuu no Ken EX | JP | 1999-04 |
Culture Brain | Commercial |
| Sesame Street - Elmo's 123s | EU | 1999-04 |
NewKidCo | Commercial |
| Sesame Street - Elmo's 123s | US | 1999-04 |
NewKidCo | Commercial |
| Sesame Street - Elmo's ABCs | EU | 1999-04 |
NewKidCo | Commercial |
| Sesame Street - Elmo's ABCs | US | 1999-04 |
NewKidCo | Commercial |
| Sakata Gorou Kudan no Renju Kyoushitsu | JP | 1999-06 |
Culture Brain | Commercial |
| Spy vs Spy | EU | 1999-06 |
Vatical Entertainment | Commercial |
| Spy vs Spy | EU | 1999-06 |
Vatical Entertainment | Prototype |
| Spy vs Spy | US | 1999-06 |
Vatical Entertainment | Commercial |
| Spy vs Spy | US | 1999-06 |
Vatical Entertainment | Prototype |
| Survival Kids - Kotou no Boukensha | JP | 1999-06 |
Konami | Commercial |
| Sangokushi - Game Boy Ban 2 | JP | 1999-07 |
Koei | Commercial |
| Spacestation Silicon Valley | EU | 1999-07 |
Take 2 Interactive | Commercial |
| Spy vs Spy | JP | 1999-07 |
Vatical Entertainment | Commercial |
| Super Mario Bros. Deluxe | EU | 1999-07 |
Nintendo | Commercial |
| Super Mario Bros. Deluxe | US | 1999-07 |
Nintendo | Commercial |
| Supershot Golf Robot | US | 1999-07 |
Digital Kids | Prototype |
| Shadowgate Return | JP | 1999-08 |
Kemco | Commercial |
| Spawn | US | 1999-09 |
Konami | Commercial |
| Space Invaders | EU | 1999-10 |
Activision | Commercial |
| Space Invaders | US | 1999-10 |
Activision | Commercial |
| Super Real Fishing | JP | 1999-10 |
Bottom Up Interactive | Commercial |
| Super Robot Taisen - Link Battler | JP | 1999-10 |
Banpresto | Commercial |
| Survival Kids | US | 1999-10 |
Konami | Commercial |
| Sylvanian Families - Otogi no Kuni no Pendant | JP | 1999-10 |
Epoch | Commercial |
| Sesame Street - The Adventures of Elmo in Grouchland | US | 1999-11 |
NewKidCo | Commercial |
| Suzuki Alstare Extreme Racing | EU | 1999-11 |
Ubisoft | Commercial |
| Soreike! Anpanman - Fushigina Nikoniko Album | JP | 1999-12 |
Tamsoft | Commercial |
| Soukoban Densetsu - Hikari to Yami no Kuni | JP | 1999-12 |
J-Wing | Commercial |
| Star Wars - Yoda Stories | EU | 1999-12 |
THQ | Commercial |
| Star Wars - Yoda Stories | US | 1999-12 |
THQ | Commercial |
| Star Wars Episode I - Racer | EU | 1999-12 |
Nintendo | Commercial |
| Star Wars Episode I - Racer | US | 1999-12 |
Nintendo | Commercial |
| Stranded Kids | EU | 1999-12 |
Konami | Commercial |
| Super Black Bass - Real Fight | JP | 1999-12 |
Starfish | Commercial |
| Super Bombliss DX | JP | 1999-12 |
Bullet-Proof Software | Commercial |
| Super Chinese Fighter EX | JP | 1999-12 |
Culture Brain | Commercial |
| Sweet Ange | JP | 1999-12 |
Koei | Commercial |