| Defense Technica | 2014 | ps3, xbox360 |
| Deformers | 2017 | ps4, xboxone |
| Dekitate High School | 1995 | snes |
| Demon King Box | 2014 | 3ds |
| Denki Blocks! | 2001 | gba, gbc |
| Densetsu no Ogre Battle - The March of the Black Queen | 1993 | snes |
| Densetsu no Ogre Battle Gaiden - Zenobia no Ouji | 2000 | ngpc |
| Der Langrisser | 1995 | snes |
| Desert Ashes | 2015 | vita |
| Desert Commander | 1989 | nes |
| Desktop Tower Defense | 2009 | nds |
| Desperados III | 2020 | ps4, xboxone |
| Devil Survivor 2 - Break Record | 2015 | 3ds |
| Diamond Trust of London | 2004 | nds |
| Die!Die!Die! | 2013 | vita |
| Digimon World Championship | 2008 | nds |
| Digital Monster Card Game - Ver. WonderSwan Color | 2002 | wsc |
| Digital Partner | 2000 | ws |
| Diner Dash - Flo on the Go | 2009 | nds |
| Dinolympics | 1992 | lynx |
| Disciples: Liberation | 2021 | ps4, xboxone |
| Disgaea - Afternoon of Darkness | 2007 | psp |
| Disgaea 2 - Dark Hero Days | 2009 | psp |
| Dishaster | 1983 | a2600 |
| Doguu Senki - Haou | 2000 | dreamcast |
| Dokidoki Cooking Series 1 - Komugi-chan no Happy Cake | 2002 | gba |
| Dokidoki Cooking Series 2 - Gourmet Kitchen - Suteki na Obentou | 2003 | gba |
| Dokuganryuu Masamune | 1988 | nes |
| Dokuritsu Sensou - Liberty or Death | 1994 | snes |
| Dotchi Mecha! | 2000 | ps1 |
| Double Breakout | 2016 | wiiu |
| Doubutsu Banchou | | n64 |
| Dr. Mario | 2014 | wiiu |
| Dragon Ball Z - Kyoushuu! Saiya Jin | 1990 | nes |
| Dragon Force | 1996 | saturn |
| Dragon Force II - Kami Sarishi Daichi ni | 1998 | saturn |
| Dragon's Earth | 1993 | snes |
| Drawn to Death | 2017 | ps4 |
| Dream Circus | 1999 | ps1 |
| Drive On Moscow | 2018 | xboxone |
| Drone Tactics | 2007 | nds |
| Dual Gear | | ps4 |
| Dual Gear | | xboxone |
| Dudes with Attitude | 1990 | nes |
| Duel Masters | 2003 | gba |
| Duel Masters | 2004 | ps2 |
| Duel Masters - Birth of Super Dragon | 2005 | ps2 |
| Duel Masters - Nettou! Battle Arena | 2003 | gc |
| Duel Masters 2 - Invincible Advance | 2004 | gba |
| Duel Masters 3 | 2004 | gba |
| Duli Zhanzheng | 1994 | genesis |
| Dune | 1984 | a2600 |
| Dune | 2000 | ps1 |
| Dune - The Battle for Arrakis | 1994 | genesis |
| Dune 2000 | 1999 | ps1 |
| Dune II - The Battle for Arrakis | 1994 | genesis |
| Dungeon Defenders | 2011 | ps3, xbox360 |
| Dungeon Defenders II | 2017 | xboxone |
| Dungeon Defenders: Awakened | 2021 | ps4, switch |
| Dungeon Twister | 2012 | ps3 |
| Dungeons & Dragons - Tactics | 2007 | psp |
| Dungeons 2 | 2016 | ps4 |
| Dungeons 3 | 2017 | ps4, xboxone |
| Dyna Brothers | 1992 | genesis |
| Dyna Brothers 2 | 1993 | genesis |
| Dynasty Tactics | 2002 | ps2 |
| Dynasty Tactics 2 | 2003 | ps2 |
| Dynasty Warriors: Godseekers | 2016 | ps3, ps4, vita |
| E.T. - The Extra-Terrestrial and the Cosmic Garden | 2002 | gbc |
| Earth Light | 1992 | snes |
| Earth Light - Luna Strike | 1996 | snes |
| Eco-Creatures - Save the Forest | 2007 | nds |
| Ecolis | 2007 | nds |
| Ecolis - Aoi Umi to Ugoku Shima | 2009 | nds |
| Ecolis - Save the Forest | 2004 | nds |
| Egg | 1998 | ps1 |
| Egypt | 1991 | nes |
| Eien no Aseria - Kono Daichi no Hate de | 2012 | psp |
| Eiyuu Sangokushi | 1993 | pcengine |
| Element Space | 2020 | xboxone |
| Elemental Monster TD Portable | 2009 | psp |
| Elements of Destruction | 2007 | nds |
| Elements of Destruction | 2008 | xbox360 |
| Emblem of Gundam | 2008 | nds |
| Emergency | 2009 | nds |
| Emergency Kids | 2004 | nds |
| Emi-chan no Moero Yakyuuken! | 1987 | fds |
| Energy Breaker | 1994 | snes |
| Engacho! for WonderSwan | 1999 | ws |
| Entombed | 1983 | a2600 |
| Espion-Age-nts | 1999 | dreamcast |
| Eufloria | 2011 | ps3 |
| Eufloria HD | 2013 | vita |
| Europa Sensen | 1993 | genesis |
| Europe Sensen | 1993 | snes |
| Evil Genius 2: World Domination | 2021 | ps4, xboxone |
| Exalegiuse | 1997 | ps1 |
| Extra Terrestrials | 1984 | a2600 |
| The Eye of Judgment | 2007 | ps3 |
| The Eye of Judgment - Legends | 2010 | psp |