| Saikyou no Igo | 1998 | ps1 |
| Saikyou no Igo 2 | 2002 | ps2 |
| Saikyou no Shougi | 1999 | ps1 |
| Sakata Gorou Kudan no Renju Kyoushitsu | 1999 | gbc |
| Saki - Achiga-Hen - Episode of Side-A Portable | 2013 | psp |
| Sakigake!! Cromartie Koukou | 2003 | ps2 |
| Sakuma-shiki Jinsei Game | 1998 | ps1 |
| Sakura Taisen Online - Paris no Yuuga na Hibi | 2001 | dreamcast |
| Sakura Taisen Online - Teito no Nagai Hibi | 2001 | dreamcast |
| Sakurai Shouichi no Jankiryuu Mahjong Hisshouhou | 1995 | snes |
| Salaryman Settai Mahjong | 2001 | ps1 |
| Saloon | | arcade |
| San Da Yi | 2005 | arcade |
| San Se Caishen | 1999 | arcade |
| San-nin Mahjong | 1984 | sg1000 |
| Sanguo Chunqiu - Sichuan Sheng | 1996 | nes |
| Sanma - San-nin Uchi Mahjong | 2001 | arcade |
| Sanrio Puroland - All Characters | 2003 | gba |
| Sanrio Shanghai | 1994 | snes |
| Sansan | 1994 | genesis |
| Sargon Chess | 1992 | cdi |
| Scacco Matto / Space Win | 1996 | arcade |
| Scandal Mahjong | 1989 | arcade |
| Schaakmat! | 2007 | nds |
| Schach | 1979 | channelf |
| Scoop! Around the World In 80 Spaces | 2019 | wiiu |
| Scrabble | 2002 | gba |
| Scrabble | 2001 | gbc |
| Scrabble | 1999 | ps1 |
| Scrabble | 2015 | ps4, xboxone |
| Scrabble - Crossword Game | 2009 | nds |
| Scrabble Interactive | 2003 | ps2 |
| Scrabble Interactive | 2009 | wii |
| Scrabble Interactive - 2007 Edition | | nds |
| Scrabble Interactive - 2009 Edition | | nds |
| Second Chance | 1985 | arcade |
| Second Love | 1986 | arcade |
| Sega Chess | 1991 | sms |
| Sega Network Taisen Mahjong MJ 2 | 2005 | arcade |
| Sega Network Taisen Mahjong MJ 3 | 2006 | arcade |
| Sega Network Taisen Mahjong MJ 3 Evolution | 2007 | arcade |
| Sega Network Taisen Mahjong MJ 3 Evolution Firmware Update | 2006 | arcade |
| Sega Network Taisen Mahjong MJ 3 Firmware Update | 2005 | arcade |
| Sega Yonin Uchi Mahjong MJ | 2002 | arcade |
| Sega Yonin Uchi Mahjong MJ Network Taisen Ver | 2003 | arcade |
| Sei Hai Densetsu | 2000 | gbc |
| Seiha | 1987 | arcade |
| Seikai Risshiden - Yoi Kuni, Yoi Seiji | 1997 | saturn |
| Sekai Saikyou Ginsei Igo | 2001 | ps1 |
| Sekai Saikyou Ginsei Igo 2 | 2003 | ps1 |
| Sekai Saikyou Ginsei Igo 3 | 2003 | ps1 |
| Sekai Saikyou Ginsei Igo 5 | 2004 | ps2 |
| Sekai Saikyou Ginsei Igo 6 | 2005 | ps2 |
| Sekai Saikyou Ginsei Igo Kouza | 2009 | ps2 |
| Sekai Saikyou Ginsei Shougi - Fuuun Ryuuko Raiden | 2011 | ps3 |
| Sekai Seifuku - Costume Fes | 2014 | vita |
| Sekai no Shougi | 2007 | nds |
| Sel-Jan | 1983 | arcade |
| Sengoku Mahjong | 1988 | pcengine |
| Sengoku Mahjong | 1991 | arcade |
| Sengoku Mahjong Kurenai Otome-tai | 1998 | arcade |
| Sengoku Turb - Fanfan I Love Me Dunce-doublentendre | 1999 | dreamcast |
| Senryaku Shougi | 1995 | ps1, saturn |
| Sentimental Journey | 1998 | ps1 |
| Sexy Gal | 1985 | arcade |
| Sexy Gal Tropical | 1985 | arcade |
| Sexy Idol Mahjong | 1993 | pcengine |
| Sexy Idol Mahjong - Fashion Monogatari | 1994 | pcengine |
| Sexy Idol Mahjong - Yakyuuken no Uta | 1995 | pcengine |
| Sexy Poker | 2009 | wii |
| Shanghai | 1987 | fds |
| Shanghai | 1989 | gb |
| Shanghai | 1990 | lynx |
| Shanghai | 1987 | arcade, nes, pcengine, sms |
| Shanghai | 2007 | wii |
| Shanghai - Banri no Choujou | 1995 | snes |
| Shanghai - Dynasty | 2000 | dreamcast |
| Shanghai Advance | 2001 | gba |
| Shanghai II | | fds |
| Shanghai II | 1990 | gg |
| Shanghai II | 1990 | nes |
| Shanghai II - Dragon's Eye | 1994 | genesis |
| Shanghai II - Dragon's Eye | 1993 | snes |
| Shanghai II - Dragon's Eye | 2010 | wii |
| Shanghai Pocket | 1998 | gb, gbc, ws |
| Shanghai Tycoon | | nes |
| Shark Party | 1996 | arcade |
| Shenzhou Jielong | | arcade |
| Shikinjou | 1991 | gb |
| Shikinjou | 1991 | genesis, nes |
| Shikinjou | 1991 | gg |
| Shiliu Zhang Mahjong - Xiangyan Meiren Pian | 1992 | genesis |
| Shiliu Zhang Mahjong II | | genesis |
| Shimura Ken no Baka Tonosama - Bakushou Tenka Touitsu Game | 2002 | gba |
| Shin 4 Nin Uchi Mahjong - Yakuman Tengoku | 1991 | nes |
| Shin DX Okuman Chouja Game - Tsukutte! Utte! Oomouke! | 2003 | ps1 |
| Shin Fortune Quest - Shokutaku no Kishitachi | 1996 | ps1 |
| Shin Honkaku Hanafuda | 1999 | dreamcast |
| Shin Mahjong | 1994 | snes |
| Shin Seiki Evangelion - Eva to Yukai na Nakamatachi | 1998 | ps1 |