| Shirotsumesouwa - Episode of the Clovers | 2003 | dreamcast |
| Shitsuji ga Aruji o Erabu Toki | 2016 | vita |
| Shoujo Kakumei Utena - Itsuka Kakumei Sareru Monogatari | 1998 | saturn |
| Shugo Chara! - 3-tsu no Tamago to Koisuru Joker | 2008 | nds |
| Shuten Order | 2025 | switch |
| Side Kicks! | 2017 | vita |
| Silent Hill Genesis | 2014 | genesis |
| The Silver Case | 2017 | ps4 |
| Silverio Vendetta - Verse of Orpheus | 2016 | vita |
| Simple 2000 Series DC Vol. 01 - Bittersweet Fools - The Ren'ai Adventure | 2002 | dreamcast |
| Simple 2000 Series DC Vol. 04 - Okaeri! The Ren'ai Adventure | 2002 | dreamcast |
| Simple 2000 Series Vol. 38 - Otoko no Tame no Bible - The Yuujou Adventure - Hotaru Soul | 2003 | ps2 |
| Simple 2000 Series Vol. 58 - The Gekai | 2004 | ps2 |
| Sister Princess - RePure | 2003 | gba |
| Snow | 2003 | dreamcast, ps2 |
| Snow Bound Land | 2013 | psp |
| Soi Kano - Gyutto Dakishimete | 2019 | vita |
| Solomon's Ring - Hi no Shou | 2012 | psp |
| Solomon's Ring - Kaze no Shou | 2012 | psp |
| Solomon's Ring - Mizu no Shou | 2013 | psp |
| Sora no Otoshimono Forte - Dreamy Season | 2011 | nds |
| Sorayume | 2014 | vita |
| Sotsugyou - 2nd Generation | 2006 | ps2 |
| Soukoku no Kusabi - Hiiro no Kakera 3 Portable | 2010 | psp |
| Sovereign of a Dying Hell | 2025 | genesis |
| Space Adventure Cobra II - Densetsu no Otoko | 1991 | pcengine |
| Spice and Wolf VR | 2019 | switch |
| Spirit Hunter: Death Mark | 2018 | ps4, vita |
| Spirit Hunter: NG | 2019 | ps4, switch, vita |
| Star Melody: Yumemi Dreamer | 2022 | switch |
| Starry Sky - After Summer Portable | 2013 | psp |
| Starry Sky - Autumn Stories | 2017 | vita |
| Starry Sky - Spring Stories | 2016 | vita |
| Starry Sky - Summer Stories | 2017 | vita |
| Starry Sky - Winter Stories | 2017 | vita |
| Steam Prison | 2021 | switch |
| Steam Prison - Nanatsu no Bitoku | 2017 | vita |
| Steam-Heart's | 1996 | pcengine |
| Steins;Gate | 2009 | ps3, psp, vita, xbox360 |
| Steins;Gate - Hiyoku Renri no Darling | 2011 | psp, vita, xbox360 |
| Steins;Gate - Linear Bounded Phenogram | 2013 | ps3 |
| Steins;Gate 0 | 2015 | ps3, ps4, switch, vita |
| Steins;Gate 0 | 2017 | xboxone |
| Steins;Gate Elite | 2018 | ps4, switch, vita |
| Steins;Gate: My Darling's Embrace | 2019 | ps3, ps4, switch |
| Stellar Theater Portable | 2013 | psp |
| Storm Lover 2nd | 2013 | psp |
| Storm Lover Natsukoi!! | 2011 | psp |
| The Story of Noah's Ark | 2009 | nds |
| Strawberry Nauts | 2016 | vita |
| SuGirly Wish | | psp |
| SuGirly Wish Limited | 2012 | psp |
| Suigetsu 2 | 2012 | ps3 |
| Suika | 2002 | dreamcast |
| Suki to Suki to de Sankaku Ren'ai | 2019 | vita |
| Summer Pockets | 2019 | switch |
| Summer Time Rendering: Another Horizon | 2023 | ps4, switch |
| Super Impostor Bros | 2021 | gbc |
| Suran Digit | 2016 | vita |
| Suzerain | 2020 | switch |
| Suzumiya Haruhi no Tsuisou | 2011 | ps3, psp |
| Suzunone Seven! Portable | 2014 | psp |
| Sweet Pool | 2018 | vita |
| Swordbreaker - The Game | 2020 | vita |
| Sympathy Kiss | 2022 | switch |
| Symphonic Rain | 2018 | switch |
| Synergia | 2021 | vita |
| Syrup and The Ultimate Sweet | 2020 | ps4, vita, xboxone |
| Taisho x Alice: Heads & Tails | 2020 | switch, vita |
| Taishou Kitan - Kotonoha Sakura | 2014 | psp |
| Taishou Mebiusline Portable | 2014 | psp |
| Taishou x Alice - All in One | | vita |
| Tales of Aravorn: Seasons of the Wolf | 2022 | switch |
| Tantei Jinguuji Saburou - Ghost of the Dusk | 2017 | 3ds |
| Tasogaredoki - Kaidan Romance | 2013 | psp |
| Tavern Talk | 2024 | switch |
| Tayutama - Kiss on My Deity | 2011 | xbox360 |
| Tayutama 2 - You're the only one | 2018 | vita |
| Team Batista no Eikou - Shinjitsu o Tsumugu 4-tsu no Karte | 2008 | nds |
| Tears to Tiara - Kakan no Daichi | 2008 | ps3 |
| Tears to Tiara II - Heir of the Overlord | 2013 | ps3 |
| Teikoku Kaleido - Kakumei no Rondo | 2017 | vita |
| Temirana: The Lucky Princess and the Tragic Knights | 2023 | switch |
| Tenchi Muyou! Toukou Muyou - Aniraji Collection | 1997 | saturn |
| Tengai ni Mau, Iki na Hana | 2018 | vita |
| Tengoku Struggle: Strayside | 2022 | switch |
| Tennis no Ouji-sama - Doubles no Ouji-sama - Girls, Be Gracious! | 2009 | nds |
| Tennis no Ouji-sama - Motto Gakuensai no Ouji-sama - More Sweet Edition | 2010 | nds |
| Tennis no Oujisama - Doki Doki Survival - Sanroku no Mystic | 2006 | ps2 |
| Tennis no Oujisama - Gakuensai no Oujisama | 2005 | ps2 |
| Tennis no Oujisama - Rush & Dream! | 2004 | ps2 |
| Tennis no Oujisama - Sweat & Tears 2 | 2003 | ps2 |
| Tenohira o, Taiyou ni | 2004 | dreamcast |
| Tenshi Tsuki no Shoujo | | vita |
| There's Nothing to Do in This Town | 2020 | gb |
| Theresia | 2008 | nds |
| Three Fourths Home - Extended Edition | 2015 | vita |
| Three Fourths Home: Extended Edition | 2015 | xboxone |
| Time Hollow | 2007 | nds |
| Time Leap | 2009 | ps3, xbox360 |