| Eliminate Down | 1993 | genesis |
| Eliminator | 1999 | ps1 |
| Elk Attack | 1987 | a2600 |
| Embargo | 1977 | arcade |
| Emergency 2012 | 2010 | nds |
| Emergency Mayhem | 2008 | wii |
| En Busca del Valle Encantado - El Retorno al Gran Valle | 2000 | ps1 |
| The End | 1982 | arcadia |
| Enen Angel | 2001 | ps1 |
| Energy | 1989 | pcengine |
| Energy Airforce - Aim Strike! | 2004 | ps2 |
| Energy Airforce AimStrike! | 2003 | ps2 |
| Engacho! | 1999 | ps1 |
| Epidemic | 1996 | ps1 |
| Eragon | 2006 | gba, nds, ps2, psp, xbox, xbox360 |
| Escape | 1982 | arcadia |
| Escape From Zombie City | 2013 | 3ds |
| The Escape from Atlantis | 1990 | nes |
| Escape from CyberCity | 1992 | cdi |
| Escape from Mars | 1980 | arcade |
| Escape from the Mindmaster | 1982 | a2600, col |
| Escape from the Planet of the Robot Monsters | 1989 | arcade |
| The Escapists | 2015 | ps4, xbox360, xboxone |
| The Escapists: The Walking Dead | 2016 | xboxone |
| Esh's Aurunmilla | 1983 | arcade |
| Eternal Champions | 1993 | genesis |
| Eureka Seven TR1 - New Wave | 2005 | ps2 |
| Eureka Seven TR1 - New Wave Graduation | 2009 | ps2 |
| Eureka Seven Vol. 1 - The New Wave | 2006 | ps2 |
| Eureka Seven Vol. 2 - The New Vision | 2006 | ps2 |
| Eurit | 1995 | snes |
| Euro Demo 01 | 1998 | ps1 |
| Evangelion - Jo | 2009 | ps2 |
| Evangelion - Jo | 2009 | psp |
| Evangelion Shin Gekijouban - 3nd Impact | 2011 | psp |
| Evergrace | 2000 | ps2 |
| Evil Dead - A Fistful of Boomstick | 2003 | ps2, xbox |
| Evolution | 1983 | col |
| Excalibur 2555 A.D | 1997 | ps1 |
| ExciteBots - Trick Racing | 2009 | wii |
| Exciting Animal Land Jr | 1993 | arcade |
| Exector | 1995 | ps1 |
| Exocet | 1983 | a2600 |
| Explosive Jake | 2020 | xboxone |
| Expressway | 2013 | jaguar |
| Extreme Pinball | 1996 | ps1 |
| Extreme Power | 1996 | ps1 |
| Extreme Sprint 3010 | 2007 | ps2 |
| Exvania | 1992 | arcade |
| Eyes | 1982 | arcade |
| Eyeshield 21 - AmeFoot Yarou ze! Ya-! Ha-! | 2005 | ps2 |
| F-117A Stealth Fighter | 1992 | nes |
| F-Zero | 2016 | wiiu |
| FIFA 18 - Legacy Edition | 2017 | ps3 |
| Fabrica de Chocolate | 2007 | sms |
| Fade to Black | 1996 | ps1 |
| Fahrenheit | 2005 | ps2, xbox |
| Fail Gate | 1991 | arcade |
| The Fairly OddParents - Shadow Showdown | 2004 | gba, gc, ps2 |
| Fairy Pinball - Yousei Tachi no Pinball | 1987 | fds |
| Fairy Tail - Zelef Kakusei | 2012 | psp |
| Fairytale Fights | 2009 | ps3, xbox360 |
| Fallen Angels | 2013 | jaguar |
| Falling | 2018 | nes |
| Fallout - Brotherhood of Steel | 2004 | ps2, xbox |
| Famicom Mini - Kidou Senshi Z Gundam - Hot Scramble | 2004 | gba |
| Famicom Mini 06 - Pac-Man | 2004 | gba |
| Famicom Mini 12 - Clu Clu Land | 2004 | gba |
| Famicom Mini 13 - Balloon Fight | 2004 | gba |
| Famicom Mini 16 - Dig Dug | 2004 | gba |
| Famicom Mini 18 - Makaimura | 2004 | gba |
| Famicom Mini 20 - Ganbare Goemon! - Karakuri Douchuu | 2004 | gba |
| Famicom Mini 22 - Nazo no Murasame Jou | 2004 | gba |
| Famicom Mini 24 - Hikari Shinwa - Palthena no Kagami | 2004 | gba |
| Family BASIC | 1984 | nes |
| Family Block | 1991 | nes |
| Family Dog | 1993 | snes |
| Family Games Compendium | 2001 | ps1 |
| Family Guy - Video Game! | 2006 | ps2, psp, xbox |
| Family Pinball | 1989 | nes |
| Family Trainer 10 - Rairai Kyonsees | 1989 | nes |
| Family Trainer 5 - Meiro Daisakusen | 1987 | nes |
| Family Trainer 6 - Manhattan Police | 1987 | nes |
| Family Trainer 9 - Fuuun Takeshi-jou 2 | 1988 | nes |
| Famous - The Road to Glory! | 2004 | nds |
| Fantasia | 1991 | genesis |
| Fantastep | 1997 | ps1, saturn |
| Fantastic Children | 2005 | gba |
| Fantastic Four | 1997 | ps1 |
| Fantastic Night Dreams - Cotton Original | 1999 | ps1 |
| Fantastic Voyage | 1982 | a2600, arcade |
| Fantasy | 1981 | arcade |
| Fantasy | 1981 | arcade |
| Fantasy Pinball | 2008 | genesis |
| Fantasy Story | 2002 | arcade |
| Fantasy Zone II | 1987 | sms |
| Fantasy Zone II - Opa-Opa no Namida | 1997 | sms |
| The Farm | 2021 | gb |
| Farmers Rebellion | 1985 | arcade, nes |
| Farmyard Fun | 1983 | a2600 |