| Darius Alpha | 1990 | pcengine |
| Darius Force | 1993 | snes |
| Darius Twin | 1991 | snes |
| Dark Arena | 2001 | gba |
| Dark Chambers | 1988 | a2600, a7800 |
| Dark Chronicle | 2002 | ps2 |
| Dark Cloud | 2000 | ps2 |
| Dark Cloud 2 | 2003 | ps2 |
| Dark Hunter Jou - Ijigen Gakuen | 1997 | ps1, saturn |
| Dark Rift | 1997 | n64 |
| Dark Seal | 1990 | arcade |
| Dark Tales - From the Lost Soul | 1999 | ps1 |
| Darklight Conflict | 1996 | ps1, saturn |
| Darkstone | 2001 | ps1 |
| Darkwing Duck 2 | 2014 | nes |
| Darwin 4081 | 1990 | genesis |
| Dash | 2021 | gb |
| Dawn of Mana | 2007 | ps2 |
| Daze Before Christmas | 1994 | genesis, snes |
| Dazzler | 1982 | arcade |
| Ddream Ddiver | 2022 | nes |
| De La Jet Set Radio | 2001 | dreamcast |
| De Sang Froid | 2000 | ps1 |
| Dead Block | 2011 | ps3, xbox360 |
| The Dead Heat Breakers | 2018 | 3ds |
| Dead Moon | 1992 | pcengine |
| Dead Moon - Getsu Sekai no Akumu | 1991 | pcengine |
| Dead Nation | 2010 | ps3, vita |
| Dead Space - Ignition | 2014 | ps3 |
| Dead in the Water | 1998 | ps1 |
| Dead or Alive | 1998 | ps1 |
| Dead or Alive - Paradise | 2010 | psp |
| Dead to Rights | 2002 | gc, ps2, xbox |
| Dead to Rights - Retribution | 2010 | ps3, xbox360 |
| Deadbeat Heroes | 2017 | xboxone |
| Deadliest Catch - Sea of Chaos | 2010 | ps3, wii, xbox360 |
| Deadly Creatures | 2009 | wii |
| Deadly Premonition - The Director's Cut | 2013 | ps3 |
| Deadly Premonition: Origins | 2019 | switch |
| Deadly Skies | 1997 | ps1 |
| Death Stranding | 2019 | ps4 |
| Death by Degrees | 2005 | ps2 |
| Death by Degrees - Tekken - Nina Williams | 2005 | ps2 |
| DeathMask | 1996 | ps1, saturn |
| Deathrow | 2002 | xbox |
| Deception III - Dark Delusion | 2000 | ps1 |
| Deception IV - Blood Ties | 2014 | vita |
| Deception IV - The Nightmare Princess | 2015 | ps3, ps4, vita |
| Deep Freeze | 1999 | ps1 |
| Deep Sea Adventure - Kaitei-kyuu Pantarassa no Nazo | 1997 | ps1 |
| Defeat Lightning | 1997 | ps1 |
| Defend Your Castle | 2008 | wii |
| Degul Degul Jjondeuk Jjondeuk - Goehon | 2005 | ps2 |
| DekaVoice | 2003 | ps2 |
| Dekoboko Densetsu - Hashiru Wagamanmaa | 1990 | pcengine |
| Delta Hero | 1992 | svision |
| Demolition Girl | 2004 | ps2 |
| Demolition Herby | 1983 | a2600 |
| Demolition Inc | 2012 | ps3 |
| Demolition Racer | 1999 | ps1 |
| Demon Attack | 1982 | a2600, g7400, intv, o2 |
| Demon's Blazon - Makaimura Monshou Hen | 1994 | snes, wiiu |
| Demon's Crest | 1994 | snes |
| Demon's Tilt | 2019 | ps4, switch, xboxone |
| Den'Z Traffic Panic | 1995 | snes |
| Dennou Senki - Virtual-On Marz | 2007 | ps2 |
| Der Herr der Ringe - Die zwei Tuerme | 2002 | ps2 |
| Der Pate | 2006 | ps2 |
| Der kleine Bar | 1983 | a2600 |
| Derelict Fleet | 2017 | ps4 |
| Derrick the Deathfin | 2012 | ps3 |
| Descent | 1996 | ps1 |
| Descent II | 1997 | ps1 |
| Descent Maximum | 1997 | ps1 |
| Desert Fox, Shooting Gallery | 1976 | channelf |
| Desolate | 2025 | snes |
| Despicable Me | 2010 | psp |
| Despicable Me - The Game | 2010 | ps2, psp, wii |
| Destination Earth | 1979 | arcade |
| Destrega | 1998 | ps1 |
| Destroy All Humans! | 2005 | ps2, xbox |
| Destroy All Humans! Big Willy Unleashed | 2008 | wii |
| Destroyer | 1992 | nes |
| Destruction Derby 2 | 1996 | ps1 |
| Destruction Derby Raw | 2000 | ps1 |
| Destructive | 1993 | snes |
| Detana Twinbee Yahoo! Deluxe Pack | 1997 | ps1 |
| Detana!! TwinBee | 1992 | pcengine |
| Deus Ex | 2002 | ps2, ps3 |
| Deus Ex - The Conspiracy | 2002 | ps2 |
| Devi to Pii | 2022 | genesis |
| Devil Crash | | wii |
| Devil Crash - Naxat Pinball | 1990 | pcengine |
| Devil Dice | 1998 | ps1 |
| Devil Fish | 1982 | arcade |
| Devil Kings | 2005 | ps2 |
| Devil Man | 1989 | nes |
| Devil Man | 2000 | ps1 |
| Devil May Cry | 2001 | ps2, switch |
| Devil May Cry | 2001 | ps2 |